Degradable sebacic acid and propyl tri-alcohol ester styptic sponge and its preparation

Abstract

A degradable styptic sponge with high safety, mechanical performance, adhesive speed and biodegradability is prepared from decanedioic acid and propanetriol through slowly raising temp to 100-160 deg.C while vacuum dewatering to obtain prepolymer, dissolving it in alcohol, adding pore-forming agent, moulding, washing with distilled water, and disinfecting by Co60 irradiation.

Description

technical field [0001] The invention relates to a degradable hemostatic sponge and a preparation method thereof, belonging to the field of medical materials. Background technique [0002] Hemostasis is one of the most basic means in surgical operations. Hemostasis plays a considerable role in the success of the operation and the safety of the patient. For the operation of the brain, liver, spleen, kidney and other substantive organs, as well as lesions with fragile and thin blood vessels For patients undergoing operations on tissues such as tumors, other operations such as tooth extraction, and patients with abnormal coagulation function, it is far from enough to rely solely on mechanical hemostasis methods such as ligation, suture, and electrocautery, and must rely on the cooperation of auxiliary hemostatic materials. At present, most of the auxiliary hemostatic materials commonly used in domestic clinical operations are gelatin hemostatic sponges. Although the gelatin hem...

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the problems of existing hemostatic sponges with poor mechanical properties (mainly manifested as brittle texture, easy to break, easy to break), high cost, slow adhesion speed, easy to fall off, and low safety. Degradable polyglycerol sebacate hemostatic sponge and preparation method thereof