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Compositions and methods for reducing vaginal ph

A composition and water-based composition technology, applied in the direction of drug combination, active ingredients of artificially synthesized polymer materials, active ingredients of anhydride/acid/halide, etc., can solve the problems of not providing anhydrous composition, low buffer capacity, etc.

Inactive Publication Date: 2007-09-12
JOHNSON & JOHNSON CONSUMER COPANIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] However, Robinson does not provide anhydrous compositions that would allow the polymer to be neutralized when exposed to a relatively alkaline environment
[0010] Organic acids such as acetic acid, sorbic acid, lactic acid, citric acid, tartaric acid, etc. used alone and applied to the vagina will lower the pH but cannot maintain a low pH because of their low buffer capacity

Method used

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  • Compositions and methods for reducing vaginal ph
  • Compositions and methods for reducing vaginal ph
  • Compositions and methods for reducing vaginal ph

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 7

[0107] Example 7: Buffer capacity

[0108] To determine the buffer capacity of the compositions of the present invention, the following procedure was used.

[0109] The amount of 0.1 N sodium hydroxide required to change the pH of the compounds described in Examples 1-5 was determined by titration. On a molar equivalent basis, the amount of sodium hydroxide solution added to the sample is indicated in the figure below.

Embodiment 6

[0110] Samples prepared in Example 6 had no buffer capacity between 3.0 and 5.5 and were designed to be delivered with a placebo buffer gel (Example 5) with the dispenser. This is an example of such a two-phase delivery system. As shown, with buffered Metrogel-Vaginal  (purchased from 3M Corporation, Minneapolis, Minnesota) to compare the data obtained in the treatment of bacterial vaginosis.

Embodiment 8

[0111] Example 8: In vitro evaluation of biological activity against bacterial vaginosis

[0112] The ability of selected vaginitis anaerobes to survive in a mixture of the agent and supplemented brucella broth was also studied. Two strengths of Brooke's broth supplemented with vitamin K and hemin were prepared and diluted with the formulation of the invention. Study organisms were taken from the refrigerator and subcultured at least twice to ensure their purity and good growth. In vitro evaluations were performed using the following procedure:

[0113] Method: Steer replicator (replicator) test (survival time expressed in hours)

[0114] 1. Mix 1 gram of test sample with 9 milliliters of dimethylsulfoxide ("DMSO"). A preparation was melted at 40-46°C and mixed well before dissolving in DMSO. Prepare 18 ml. Take out a small volume to measure and record the pH. Place in a reaction chamber and exclude from oxygen for at least 2 hours.

[0115] 2. Operate in a reaction cha...

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Abstract

This invention relates to aqueous buffered compositions and methods for lowering vaginal pH and reducing the level of self-perceived vaginal odor. Such compositions may be applied to the vaginal area to lower vaginal pH and assist in maintaining such pH over a period of time.

Description

[0001] This application is a copy of U.S. Patent Application Serial Nos. 10 / 109,097 and 10 / 128,611, filed March 28, 2002, and April 23, 2002, respectively, and Serial No. _____, filed September 12, 2005 (Attorney Docket No. PPC833CIP2 ), which is incorporated herein by reference. technical field [0002] The present invention relates to compositions and methods for maintaining a healthy vaginal pH and controlling vaginal odor. Background technique [0003] Bacterial vaginosis is an altered flora, the cause of which remains unknown in most cases. Bacterial vaginosis is often used to denote any change in the vaginal flora due to a hypothetical loss of lactobacilli. However, whether this microbiota represents the genetically normal vaginal status of all women is uncertain. Most recommended treatments for bacterial vaginosis in nonpregnant women are usually successful only in the short term and often unsuccessful if followed up long term. Although bacterial vaginosis is gener...

Claims

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Application Information

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IPC IPC(8): A61K31/78A61K31/19A61K9/02A61P15/02
Inventor N·艾哈迈德C·-J·崔A·弗S·Y·林
Owner JOHNSON & JOHNSON CONSUMER COPANIES
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