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Novel use of tizanidine or its derivatives

A technology of tizanidine and its derivatives, applied in the field of insomnia treatment, can solve the problems of insomnia and prolong fast wave sleep without tizanidine, and achieve the effect of treating insomnia and improving sleep function

Active Publication Date: 2007-10-03
SICHUAN CREDIT PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is no relevant report on the use of tizanidine in the treatment of insomnia, and there is no relevant report on tizanidine in the treatment of insomnia with difficulty falling asleep and prolonging fast wave sleep

Method used

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  • Novel use of tizanidine or its derivatives
  • Novel use of tizanidine or its derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 The preparation of medicine of the present invention

[0036] Tizanidine Hydrochloride 0.5g (1000 capsules or 1000 tablets)

[0037] Starch 200g

[0038] Microcrystalline Cellulose 5g

[0039] After the tizanidine hydrochloride and starch are mixed uniformly by the method of equal increase, then mixed with microcrystalline cellulose, granulated and compressed into tablets to obtain tablets; or packed into capsules to obtain capsules.

Embodiment 2

[0040] Embodiment 2 The preparation of medicine of the present invention

[0041] Tizanidine Hydrochloride 1g (1000 pills)

[0042] Flavor 1.5g

[0043] Distilled water 500ml

[0044] Starch 80g

[0045] Dextrin 20g

[0046] Mix tizanidine hydrochloride and starch uniformly by the method of equal increase, then mix with dextrin and flavoring agent, make pills, and dry to obtain.

Embodiment 3

[0047] Embodiment 3 The preparation of medicine of the present invention

[0048] Tizanidine 2g (1000 capsules or 1000 tablets)

[0049] Starch 80g

[0050] Microcrystalline Cellulose 20g

[0051] After the tizanidine and starch are uniformly mixed by the method of equal increase, then mixed with microcrystalline cellulose, granulated, and compressed into tablets to obtain tablets; or packed into capsules to obtain capsules.

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PUM

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Abstract

An application of tizanidine or its derivative in preparing the medicines for treating insomnia, elongating SWS sleeping and preventing senile dementia is disclosed.

Description

technical field [0001] The invention relates to a new application of tizanidine or a derivative thereof, specifically, an application in treating insomnia, and belongs to the field of medicine. Background technique [0002] The definition of insomnia usually refers to the lack of sleep caused by various reasons, the time and quality of sleep can not meet the normal sleep requirements or can not meet the physiological needs of the body, and a short-term symptom occurs due to adverse effects on various functions during the day. (Ci Shuping, Zhang Xilong, Yang Yu, Pan Jiyang, Wang Shi, Liu Jun, "Sleep and Sleep Diseases", ISBN 7-80121-684-9, Beijing Military Medical Science Press, pp. 177-178) [0003] Classified according to the time of insomnia, insomnia can be divided into: initial insomnia (difficulty falling asleep insomnia, initial insomnia); persistent insomnia (repeated insomnia, intermittent insomnia); sexual insomnia, terminal insomnia); sleepless nights (overnight i...

Claims

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Application Information

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IPC IPC(8): A61K31/433A61K9/00A61P25/20A61P25/28
Inventor 陈刚
Owner SICHUAN CREDIT PHARMA
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