Compositions for the treatment of tumour

A composition and tumor technology, applied in the direction of anti-tumor drugs, drug combinations, active ingredients of heterocyclic compounds, etc., can solve the problems of unpredictable positive results and other problems

Inactive Publication Date: 2008-06-18
COMBINATORX
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite a long history of multidrug combination therapy in cancer, especially in multidrug-resistant cancers, positive outcomes with combination therapy are often unpredictable

Method used

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  • Compositions for the treatment of tumour
  • Compositions for the treatment of tumour
  • Compositions for the treatment of tumour

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0145] Male adult SCID Hsd: ICR9 CD-1 mice (Harlan, Indianapolis, IN) aged 6-8 weeks were used for animal experiments. About 1×10 6 HCT116 or A549 human tumor cells (obtained directly from ATCC) were injected subcutaneously into the left and right abdomen of each animal. Monitor the tumor growth in animals, when the tumor volume reaches about 500mm 3 At time, the animals were randomly divided into treatment groups (n=10).

[0146] The composition of chlorpromazine / pentamidine (CRx-026) with a weight ratio of 1:2 was administered as an intraperitoneal bolus at a concentration of 0.97 mg / ml and 1.87 mg / ml in 5% glucose. For two weeks, or at a concentration of 23 mg / ml and 44 mg / ml, respectively, in a 5% glucose solution containing 10% ethanol, administered via an ALZET osmotic mini pump implanted intraperitoneally for two weeks. The amount administered by each method was 5 mg chlorpromazine / kg body weight and 10 mg pentamidine / kg body weight.

[0147] During the treatment, the tumor...

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Abstract

The invention features a method for treating a patient having a cancer or other neoplasm by administering to the patient a composition that includes a phenothiazine and another active agent, where predetermined plasma drug levels are achieved and maintained for 12 hours or more.

Description

Background of the invention [0001] The present invention relates to the treatment of tumors, such as cancer. [0002] Cancer is a disease characterized by the uncontrolled growth of abnormal cells. Cancer cells have overcome the obstacles imposed on normal cells with a limited lifespan and grow indefinitely. As the cancer cells continue to grow, genetic changes can continue to occur until the cancer cells have shown a more aggressive growth phenotype. Without treatment, metastasis is the spread of cancer cells to remote areas of the body through the lymphatic system or blood flow, which will surely destroy healthy tissues. [0003] The fact that there is considerable diversity even in one type of cancer has hindered the treatment of cancer. Certain cancers, for example, have the ability to invade tissues and exhibit an aggressive growth process characterized by metastasis. These tumors are usually related to the patient's poor prognosis. In the final analysis, tumor diversity lead...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/55
CPCA61K31/5415A61K31/655A61K31/496A61K31/538A61K31/473A61K31/55A61P35/00A61K2300/00
Inventor P·埃利奥特D·格劳M·帕瓦尔G·N·塞尔贝奇亚
Owner COMBINATORX
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