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Two anti-cancer medicament raw material compounds

A technology of anti-cancer drugs and compounds, applied in 5 fields, to achieve the effect of inducing tumor cell apoptosis and inhibiting growth in vivo

Inactive Publication Date: 2008-07-09
张南
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Data show that 3,3',4',5,6,7,8-heptamethoxyflavone inhibits P-glycoprotein-mediated export of [3H]vincristine, leading to intracellular accumulation of chemotherapeutic drugs

Method used

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  • Two anti-cancer medicament raw material compounds
  • Two anti-cancer medicament raw material compounds
  • Two anti-cancer medicament raw material compounds

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Experimental program
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Embodiment Construction

[0040] In order to prove the medicinal effect of the raw material compound of the present invention, the following methods can be used to verify:

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Abstract

The invention belongs to the chemical medicine field, in particular to two anti-cancer medicine raw material compounds. The invention synthesizes several chemical raw materials to obtain novel 3- methoxy flavoine derivative-compound 5, 7-dihydroxy-8-(1, 1-dimethylaniline-3, 3', 4'- 3-methoxyflavone and compound 5, 7-dihydroxy-8-(1, 1-dimethylaniline-3, 4'- 2-methoxyflavone in four steps. The two compounds can reach the level of poly-methoxyl flavones (PMFS) compound which is separated from natural plants and poly-methylation flavones C-glycosylated derivative which are separated from medical plants, which have equal role and effect of inhibiting human tumor generation, play positive inhibition in anti-inflammatory diseases and anti-atherosclerosis diseases, and are two important raw materials of wide-spectrum antineoplastic medicines.

Description

Technical field: [0001] The invention belongs to the field of chemical medicines, in particular to two anticancer drug raw material compounds 5,7-dihydroxy-8-(1,1-dimethylaniline)-3,3',4'-trimethoxyflavone, and 5,7-Dihydroxy-8-(1,1-dimethylaniline)-3,4'-dimethoxyflavone. Background technique: [0002] 3-Methoxyflavones belong to polymethoxyflavonoids (PMFs) isolated from citrus plants. Due to their broad-spectrum biological activities including anti-inflammatory, anti-cancer and anti-atherosclerosis, they have been received special attention. There is growing interest in exploring the health properties of PMFs in citrus fruit. Therefore, the isolation and identification of PMFs from sweet orange peel will enable new applications of by-products of orange juice processing, as well as the consumption of oranges in other health products and pharmaceuticals. [0003] PMFs achieve their anticancer effects through different potential mechanisms. 3,3',4',5,6,7,8-heptamethoxyflav...

Claims

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Application Information

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IPC IPC(8): C07D311/28A61K31/353A61P35/00
Inventor 张南
Owner 张南
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