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Reagent for assaying antiphospholipid antibody and reagent for assaying anti-treponema pallidum antibody

A technology of anti-phospholipid antibody and Treponema pallidum, applied in biological testing, measuring devices, material inspection products, etc., can solve the problems of inability to obtain measurement results, serum interference, etc.

Active Publication Date: 2009-01-07
SEKISUI MEDICAL CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, although such sensitizers are excellent in promoting antigen-antibody reactions, accurate measurement results cannot be obtained with some samples.
Specifically, when the specimen is serum, by changing the components contained in the serum, a phenomenon called serum interference that adversely affects the measurement occurs, and accurate measurement results cannot be obtained.

Method used

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  • Reagent for assaying antiphospholipid antibody and reagent for assaying anti-treponema pallidum antibody
  • Reagent for assaying antiphospholipid antibody and reagent for assaying anti-treponema pallidum antibody
  • Reagent for assaying antiphospholipid antibody and reagent for assaying anti-treponema pallidum antibody

Examples

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Effect test

Embodiment 2

[0096] (1-1) In the preparation of the first reagent, in a phosphate buffer containing 1% bovine serum albumin (LotA: Serologicals), 0.70% by weight of Lipidel D03 neutralized with NaOH was added (Manufactured by NOF Corporation, molecular weight 1 million), except that the first reagent was prepared from this, the same procedure as in Example 1 was carried out to prepare an antiphospholipid antibody measurement reagent.

Embodiment 3

[0098] (1-1) In the preparation of the first reagent, in a phosphate buffer containing 1% bovine serum albumin (LotA: Serologicals), 0.45% by weight of Lipidr D05 neutralized with NaOH was added (Manufactured by NOF Corporation, molecular weight 1 million), except that the first reagent was prepared from this, the same procedure as in Example 1 was carried out to prepare an antiphospholipid antibody measurement reagent.

Embodiment 4

[0116] (1-1) In the preparation of the first reagent, in a phosphate buffer containing 1% bovine serum albumin (LotB), 0.66% by weight of Lipidel D03 neutralized with NaOH (Nippon Oil & Fats Co., Ltd.) Manufacturing), except that the same procedure as in Example 1 was performed to prepare an antiphospholipid antibody measurement reagent.

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Abstract

The invention aims to provide a reagent for assaying an antiphospholipid antibody which is excellent in long-term storage stability and capable of diagnosing syphilis infection or the like and a reagent for assaying an anti-Treponema pallidum antibody which is capable of diagnosing syphilis infection with high accuracy by preventing the occurrence of serum interference. The invention is directed to the reagent for assaying an antiphospholipid antibody to be used for diagnosing syphilis infection comprising an insoluble carrier carrying an antiphospholipid antigen and a copolymer with a segment derived from 2-methacryloyloxyethyl phosphorylcholine and a segment derived from a hydrophilic monomer.

Description

Technical field [0001] The present invention relates to an anti-phospholipid antibody assay reagent capable of accurately diagnosing syphilis infection and excellent long-term storage stability, and anti-Treponema pallidum capable of accurately diagnosing syphilis infection by preventing the occurrence of serum interference Antibody assay reagents. Background technique [0002] Treponema Pallidum, a syphilis pathogen, once infects organisms, it produces antibodies against the pathogen and antibodies that are reactive with phospholipids. The antiphospholipid antibody measuring reagent is a reagent for judging syphilis infection by measuring the presence or absence of antibodies reactive with phospholipids in the blood. [0003] Conventionally, in antiphospholipid measurement, manipulative methods such as RPR card test using a judgment plate have been performed, but in recent years, reagents (automated reagents) that can be applied to automatic biochemical analyzers are being sold....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/531G01N33/545G01N33/571G01N33/92
Inventor 赤峰隆之大田哲也李艳
Owner SEKISUI MEDICAL CO LTD
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