Achyranthes bidentata dispensing granule as well as preparation method and quality control method

A technology of formula granules and Achyranthes, applied in the field of formula granules of Achyranthes and its preparation, can solve the problems such as difficulty in analysing the spectrum

Active Publication Date: 2009-07-08
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the fact that Chinese herbal medicines, herbal pieces and Chinese patent medicines are much more complex mixture systems than western medicines, it is difficult to analyze the s...

Method used

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  • Achyranthes bidentata dispensing granule as well as preparation method and quality control method
  • Achyranthes bidentata dispensing granule as well as preparation method and quality control method
  • Achyranthes bidentata dispensing granule as well as preparation method and quality control method

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Experimental program
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Effect test

Embodiment 1

[0036] Embodiment 1: Achyranthes knuckle formula granules

[0037] Take 100kg of Achyranthes bidentata decoction pieces, add 800kg of water, extract for 2 hours, that is, the first decoction; after the first decoction, add 800kg of water to the dregs, extract for 1.5 hours, that is, the second decoction; combine the two decoction liquids, and concentrate under reduced pressure to a relative density of 1.05- 1.10; the concentrated solution is preheated at 45°C, the inlet air temperature is 180°C, the material pump speed is 550 rpm, the outlet air temperature is 80°C, and the air supply temperature is 45°C, and spray-dried to obtain Achyranthes bidentata spray-dried powder; Add its own weight portion 0-5% auxiliary material dextrin in the knee spray-dried powder; the pressure of the spray-dried powder of Achyranthes bidentata is 5MPa on the main pressing wheel, the pressure on the side pressing wheel is 0.5MPa, the spindle speed is 400 rpm, and the feeding voltage Dry granulatio...

Embodiment 2

[0038] Embodiment 2: Achyranthes knuckle formula granules

[0039] Take 100kg of Achyranthes bidentata decoction pieces, add 1000kg of water, extract for 2 hours, that is the first decoction; after the first decoction, add 600kg of water to the dregs, extract for 1 hour, that is the second decoction; combine the two decoction liquids, concentrate under reduced pressure to a relative density of 1.00- 1.05; the concentrated solution is preheated at 50°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air delivery temperature is 50°C, and it is spray-dried to obtain Achyranthes bidentata spray-dried powder; Add 5-15% of its own weight of auxiliary material dextrin to the knee spray-dried powder; under the conditions that the pressure of the main pressure roller is 6MPa, the pressure of the side pressure roller is 0.4MPa, the rotation speed of the main shaft is 450 rpm, and the feeding voltage is 110V Dry granula...

Embodiment 3

[0041] Embodiment 3: Achyranthes knuckle formula granules

[0042] Take 100kg of Achyranthes knuckles, add 1400kg of water, extract for 2.5 hours, that is, the first decoction; after the first decoction, add 1100kg of water to the dregs, extract for 2.5 hours, that is, the second decoction; combine the two decoctions, concentrate under reduced pressure to a relative density of 1.10— 1.15; the concentrated solution is preheated at 45°C, the inlet air temperature is 170°C, the material pump speed is 600 rpm, the outlet air temperature is 75°C, and the air supply temperature is 50°C, and the spray-dried powder is obtained to obtain Achyranthes bidentata spray-dried powder; Add 15-25% of its own weight of lactose to the knee spray-dried powder; dry process under the conditions that the pressure of the main pressure roller is 4MPa, the pressure of the side pressure roller is 0.4MPa, the rotation speed of the main shaft is 500 rpm, and the feeding voltage is 130V Achyranthes bidenta...

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Abstract

The invention discloses an achyranthes prescription granule and a preparation method as well as a quality control method thereof. The prescription granule uses achyranthes decoction pieces as raw materials to prepare the achyranthes prescription granule through the technique procedures, such as twice water extraction, vacuum concentration, sponging drying, etc. 1g of the achyranthes prescription granule is equal to 3-5g of crude drug. The quality of the achyranthes decoction pieces and the achyranthes prescription granule are identified by using infrared fingerprint spectra. The achyranthes prescription granule of the invention has complete and advanced production technique, specific and controllable quality control standard, scientific, advanced, rapid and operable detecting method related to the quality standard. A great number of experiments prove that the prepared soup of the achyranthes prescription granule and the mixed simmered liquid of the classical prescription decoction pieces containing achyranthes have equal components, thus realizing the technique of full ingredient prescription granule and proving the reasonability of the technique of the invention; and in the invention, infrared spectroscopy technology is used for the quality control of the traditional Chinese medicines, rapidly solving a primary problem in macroscopic quality control of the traditional Chinese medicines-the identification of the truth of traditional Chinese medicines.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule and its preparation method and quality control method, in particular to a Achyranthes bidentata formula granule and its preparation method and quality control method. Background technique [0002] Traditional Chinese medicine formula granules, under the guidance of the theory of traditional Chinese medicine, are made of Chinese herbal decoction pieces through various processes, and are used in clinical prescriptions of traditional Chinese medicine. Compared with traditional Chinese medicine decoction, it is convenient to take and the dosage is small , the quality is controllable, easy to store, and easy to carry; Chinese medicine formula granules are currently in the pilot production state in China, and the product technology and quality standards are not uniform. At present, traditional Chinese medicine formula granules are mostly extracted with water, or extracted with water afte...

Claims

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Application Information

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IPC IPC(8): A61K36/21A61K9/16A61J3/00G01N21/35G01N21/3563
Inventor 吴玢付静张翠
Owner BEIJING KANGRENTANG PHARMA
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