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Method for extracting Ganoderma lucidum triterpenes components

An extraction method and technology of triterpenoids, applied in the field of extraction of triterpenoid components of Ganoderma lucidum, can solve the problems of high production cost, low flow rate, high viscosity, etc., and achieve the effects of reduced production cost, high extraction rate and easy operation

Active Publication Date: 2011-05-11
NANJING ZHONGKE GRP CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

3) Radiotherapy and chemotherapy are important means of tumor treatment. Radiotherapy and chemotherapy can quickly kill tumor cells, but at the same time it will also damage normal cells in the body, including the immune system, causing great damage to the body, resulting in low immune function of the body, and harmful to tumors. Cells multiply defenselessly
[0004] At present, the extraction methods of Ganoderma lucidum triterpenoids mainly include macroporous adsorption resin method and chromatographic column preparation method. Since Ganoderma lucidum spore oil contains a large amount of oil components and has a high viscosity, these two methods are not suitable for large-scale production.
Moreover, grease has a great influence on the resin and chromatographic column, the flow rate is low, the damage to the resin and chromatographic packing is great, and the production cost is extremely high

Method used

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  • Method for extracting Ganoderma lucidum triterpenes components
  • Method for extracting Ganoderma lucidum triterpenes components
  • Method for extracting Ganoderma lucidum triterpenes components

Examples

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Effect test

Embodiment 1

[0042] Select ganoderma lucidum spore powder (wall breaking rate 95%) and add water, add water so that the ganoderma lucidum spore powder can be bonded and formed, extrude it with an extruder, weigh 100KG after drying, put it into an extractor, and control the pressure 26MPa, temperature 50°C, continuous extraction for 30 hours, and 15.8KG Ganoderma lucidum spore oil was isolated (specifically prepared according to Patent Example 1 of Patent No. 99123952.0). Take 100 g of ganoderma lucidum spore oil, add about 0.5 g of analytically pure powdered activated carbon, oscillate and stir for about 30 minutes, and filter with suction to remove pigment impurities in the oil to obtain 95.6 g of oil. Add 300ml of analytically pure ether, extract and shake for 5 minutes, remove the ether solution after standing for stratification, and remove most of the oil and fat components for 3 consecutive times to obtain a sample of 12.5g. Add 30ml of analytically pure n-butanol, vibrate and extract...

Embodiment 2

[0044] Select ganoderma lucidum spore powder (wall breaking rate 95%) and add water, add water so that the ganoderma lucidum spore powder can be bonded and formed, extrude it with an extruder, weigh 100KG after drying, put it into an extractor, and control the pressure 26MPa, temperature 50°C, continuous extraction for 30 hours, and 15.8KG Ganoderma lucidum spore oil was isolated (specifically prepared according to Patent Example 1 of Patent No. 99123952.0). Take 100 g of Ganoderma lucidum spore oil, add about 0.5 g of analytically pure powdered activated carbon, oscillate and stir for about 35 minutes, and filter with suction to remove pigment impurities in the oil to obtain 96.1 g of oil. Add 300ml of analytically pure ether, extract and shake for 5 minutes, remove the ether solution after standing for stratification, and remove most of the oil components in it for 4 consecutive times to obtain a sample of 12.8g. Add 30ml of analytically pure n-butanol, vibrate and extract, ...

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Abstract

The invention discloses a method for extracting a ganoderma triterpene component, which is characterized in that a crude terpene product is obtained by ganoderma lucidum spore oil mainly through the decolorization of activated carbon, the degreasing of ethyl ether and the extraction of normal butanol, then absolute ethyl alcohol and acetone are adopted to refine to obtain the ganoderma triterpenecomponent, and the content of ganoderma triterpene is more than or equal to 85 percent in the obtained ganoderma triterpene component. The method has simple and convenient operation and reduces production cost, the obtained ganoderma triterpene component has high extraction rate, and the content of the ganoderma triterpene is also higher.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a method for extracting ganoderma triterpenoids. Background technique [0002] Ganoderma lucidum is also known as Ruicao and Ganoderma lucidum. The research on Ganoderma lucidum has a history of at least two thousand years in my country. Regarding the medicinal effects of Ganoderma lucidum, Li Shizhen said: "It is mainly used to cure deafness, benefit joints, protect the mind, benefit essence and energy, strengthen muscles and bones, improve color, take long-term use to lighten body and not grow old, prolong life, cure fatigue, and cure hemorrhoids." In the past 40 years, a lot of scientific research and clinical application work have been carried out on Ganoderma lucidum. The confirmed active ingredients of Ganoderma lucidum include Ganoderma lucidum polysaccharide, which has the function of immune regulation, and Ganoderma acid has strong pharmacological...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/074A61P35/00A61P37/02
Inventor 冯敏沈建钱一帆
Owner NANJING ZHONGKE GRP CORP LTD