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Combination containing micronized gliquidone

A kind of technology of glitazone and composition, applied in the field of compositions containing micronized glitazone, and can solve problems such as poor dissolution rate

Inactive Publication Date: 2009-07-29
北京华禧联合科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, the dissolution rate of micronized gliquidone is even worse than that of its common crystalline form

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Tablet composition:

[0032] Composition weight (%)

[0033] Gliquidone 12.1

[0034] Lactose 52.3

[0035] Microcrystalline cellulose 8

[0036] Sodium Carboxymethyl Starch 4

[0037] Povidone K30 2

[0038] Micronized silica gel 0.3

[0039] Magnesium stearate 0.5

[0040] Polysorbate 80 0.8

[0041] Starch 20

[0042] Total 100.0

[0043] (1) Micronization of gliquidone

[0044] A vibrating ultrafine pulverizer was used to micronize 1 kg of gliquidone. When the particles are small enough to be carried away by the air stream to form a wind screen, they are collected to obtain a micronized compound.

[0045] (2) Preparation of binder solution

[0046] Under magnetic stirring, dissolve povidone K30 and polysorbate 80 in an appropriate amount of purified water.

[0047] (3) Preparation of particles

[0048] Mix gliquidone powder, lactose, microcrystalline cellulose, starch, sodium carboxymethyl starch, use a binder solution to make soft materials, pass through a 20-mesh siev...

Embodiment 2

[0052] Using non-micronized gliquidone, tablets were prepared according to the procedures of Example 1 (2) to (4).

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Abstract

The invention relates to a pharmaceutical composition taking gliquidone which contains micronization as an active component and a method for preparing the composition. Micronized gliquidone is mixed with a surfactant and a proper excipient, palletized and tabletted to obtain the pharmaceutical composition taking the gliquidone which contains the micronization as the active component. The pharmaceutical composition greatly improves the water solubility of the gliquidone, thereby ensuring that the gliquidone is almost completely dissolved out from the composition.

Description

Technical field [0001] The present invention relates to a pharmaceutical composition containing gliquidone in a micronized solid form as an active ingredient and a method for preparing the composition. Background technique [0002] The pharmaceutical composition of the present invention is a solid or semi-solid pharmaceutical composition. Significant solid pharmaceutical compositions, such as powders, pills, capsules and tablets, etc. The term "semi-solid pharmaceutical composition" refers to a pharmaceutical composition composed mainly of solid active ingredients dispersed in a (high) viscous formulation. Significant semi-solid pharmaceutical compositions, such as suppositories, emulsions, gelling agents and ointments, etc. [0003] The preferred solid dosage form within the scope of the present invention is a tablet. Those skilled in the art must consider the characteristics of the tablet when studying the composition. The specific characteristics of tablets are shape, dissolut...

Claims

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Application Information

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IPC IPC(8): A61K31/4725A61K9/20A61K9/00A61K47/34A61P3/10
Inventor 谢晓东
Owner 北京华禧联合科技发展有限公司
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