Method for drying hydrocortisone sodium succinate asepsis powder

A technology of hydrocortisone sodium succinate and drying method, which is applied in organic chemistry, steroids, spray evaporation, etc., can solve the problems of reduced cleanliness of sterile environment, unstable physical and chemical properties, dust pollution, etc., and achieves The moisture content of the product is stable, which solves the problem of thermal deterioration and ensures the effect of uniform drying

CN101559287BActive Publication Date: 2010-10-13TIANJIN BIOCHEM PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Publication Date
2010-10-13

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Abstract

The invention discloses a method for drying hydrocortisone sodium succinate asepsis powder, which comprises the following steps: delivering filtered hydrocortisone sodium succinate water solution intoa temperature control tank, delivering the water solution after passing through a second precision filter into a spray drying tower, atomizing the water solution through an atomizer, and contacting the water solution with hot aseptic air to be dried. The top inside the spray drying tower is provided with a hot air distributor which comprises an inner pipe and an air deflector, the lower part of the air deflector is bent to one side, the outer surface of the tower wall of the spray drying tower is provided with a tower wall shaking device, one end of a dust discharge pipe is connected with anair hammer chamber, the other end of the dust discharge pipe is arranged outside a sterile room, the air hammer chamber is hermetically connected with the tower wall of the spray drying tower, and thedried hydrocortisone sodium succinate asepsis powder is discharged from a discharge hole at the bottom of the spray drying tower and collected by a cyclone separator. The method strictly ensures asepsis of liquid medicine, ensures even drying of materials, avoids dust pollution, and strictly ensures the cleanliness of the sterile room.
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Description

technical field

[0001] The invention belongs to the field of preparation of chemicals, in particular to a method for drying hydrocortisone sodium succinate sterile powder. Background technique

[0002] The hydrocortisone sodium succinate aqueous solution prepared by chemical synthesis can be prepared into hydrocortisone sodium succinate sterile powder by several methods. Such as the vacuum freeze-drying method, the method is to freeze-dry a certain concentration of hydrocortisone sodium succinate solution to obtain solid block-shaped hydrocortisone sodium succinate, and then pulverize and screen to obtain a powder product. This method has the following disadvantages in the production process: (1) the production process requires high-power refrigeration equipment to cool down the liquid medicine in the freezer, which consumes a lot of energy, and the production cost is high, and the drying time is long and the drying efficiency is low. (2) Since the weight loss on drying of ...

Examples

Embodiment Construction

[0020] The present invention will be further described below in conjunction with the accompanying drawings.

[0021] Such as figure 1 Shown, a kind of drying method of hydrocortisone sodium succinate aseptic powder, comprises the steps: the hydrocortisone sodium succinate aqueous solution that concentration is 100g / L-200g / L is input temperature control tank 4 after filtering In the process, after passing through the second fine filter 5, it is input into the spray drying tower 8, after being atomized by the atomizer 6, it is contacted with hot sterile air for drying, and the hot sterile air is input into the spray drying tower from the air inlet pipe 13, The top of the spray drying tower is provided with a hot air distributor 7, the hot air distributor includes an inner pipe 17 and an air deflector 16, the lower part of the air deflector is bent to one side, and the outer surface of the spray drying tower wall is provided with a tower wall shock absorber. Beating device, the ...