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Organic silicon separation gel and preparation method and application thereof

A technology of silicone and separation gel, applied in material inspection products, biological testing and other directions, can solve problems such as the impact of test results, achieve good physiological inertia, strengthen quality control, and ensure stability.

Active Publication Date: 2009-11-04
广州标美药用辅料有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no strict requirements on low molecular weight, which will affect the test results

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 25 parts of 350cP, 40 parts of 10000cP, 10 parts of 10000000cP linear silicone polymer, 5 parts of 100cP hydroxyl silicone oil, 20 parts of fumed silica treated with hexamethyldisilazane, 1 part of silane joint agent. After mixing the above raw materials evenly, raise the temperature to 60°C and keep it warm for 9 hours, then raise the temperature to 180°C, remove low molecules under negative pressure for 1 hour, control the vacuum degree at -0.09mpa, and obtain the separating gel after cooling. When testing, add about 1.5g of separation gel to the prepared blood collection tube, add blood into the blood collection tube, centrifuge at 2000G for 5min after coagulation, after separation, the separation gel is between serum and plasma, put it upside down, and lay it flat Serum and plasma can no longer be mixed.

Embodiment 2

[0030] Take 10 parts of 50cP, 30 parts of 1000cP, 30 parts of 10000000cP linear silicone polymer, 7 parts of 100cP hydroxyl silicone oil, and 18 parts of fumed silica treated with hexamethyldisilazane and methylchlorosilane for hydrophobic treatment , 3 parts of silane coupling agent. After mixing the above raw materials evenly, raise the temperature to 90°C and keep it warm for 11 hours, then raise the temperature to 155°C, remove low molecules under negative pressure for 4 hours, control the vacuum at -0.09mpa, and obtain the separating gel after cooling. When testing, add about 1.5g of separation gel to the prepared blood collection tube, add blood into the blood collection tube, centrifuge at 1500G for 10 minutes after coagulation, after separation, the separation gel is between serum and plasma, put it upside down, and lay it flat Serum and plasma can no longer be mixed.

Embodiment 3

[0032]Take 50 parts of 1000cp, 19 parts of 10000000cp linear silicone polymer, 15 parts of 100cp hydroxyl silicone oil, and 15 parts of hydrophobization with hexamethyldisilazane, tetramethyldivinyldisilazane and methylchlorosilane Treated fumed silica, 6 parts of silane coupling agent. After the above raw materials were mixed evenly, the temperature was raised to 116°C for 5 hours, and then the temperature was raised to 120°C, and the low molecular weight was removed for 6 hours under negative pressure. The vacuum degree was controlled at -0.09mpa, and the separation gel was obtained after cooling. When testing, add about 1.5g of separation gel to the prepared blood collection tube, add blood into the blood collection tube, centrifuge at 1000G for 5min after coagulation, after separation, the separation gel is between serum and plasma, put it upside down, and lay it flat Serum and plasma can no longer be mixed.

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Abstract

The invention discloses an organic silicon separation gel and a preparation method and application thereof. The organic silicon separation gel is prepared from the following components by weight portion: 54 to 82 portions of organopolysiloxane, 4 to 15 portions of hydroxy silicone oil, 10 to 25 portions of gas phase method silicon dioxide subjected to hydrophobization treatment by the silicoorganic compound and 1 to 6 portions of silane coupling agent. The preparation method of the organic silicon separation gel comprises the following steps: evenly mixing the components; increasing the temperature to between 60 and 116 DEG C; stirring the mixture and maintaining the temperature for 5 to 12 hours; carrying out vacuuming on the mixture for 1 to 6 hours at a temperature of between 120 and 180 DEG C; and obtaining the organic silicon separation gel. The application of the organic silicon separation gel is that the gel is used for preparing a rapid blood collecting tube containing serum separation gel. The organic silicon separation gel provided by the invention has the advantages of sanitation, safety, no toxicity, strong isolation property, good liquid seal property and excellent thixotropic property. The preparation method of the organic silicon separation gel has simple preparation method and process, mild and controllable preparation condition and is easy to popularize.

Description

technical field [0001] The invention relates to a preparation method and application of organic silicon separating gel. Background technique [0002] Health has always been the ideal pursued by human beings, and today more and more people are tempted by their own health conditions. Now many people in the society are in a state of sub-health, how can we help human beings to regulate their health? The development of medical science provides a convenient door for human beings. The medical industry is an important industry related to the national economy and the people's livelihood. The country has proved its importance through a series of laws and regulations. In recent years, due to the development of new technologies, some new technologies and methods have gradually been widely used. Vacuum blood collection tube is a new mainstream method for rapid blood collection and testing in recent years. Blood testing is extremely important for blood collection and protection before...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L83/04C08K9/06G01N33/49B01D43/00
Inventor 王海鹏黄振宏
Owner 广州标美药用辅料有限公司
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