Treatment of inflammation and/or endotoxic shock

A technology of endotoxin and inflammation, applied in the direction of anti-toxic agent, anti-inflammatory agent, anti-viral agent, etc.

Active Publication Date: 2010-02-03
OXFORD UNIV INNOVATION LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some individuals are allergic to NSAIDs, and people with asthma are at higher risk of severe allergic reactions to aspirin

Method used

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  • Treatment of inflammation and/or endotoxic shock
  • Treatment of inflammation and/or endotoxic shock
  • Treatment of inflammation and/or endotoxic shock

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0129] Chemerin140 exerts anti-inflammatory effects on activated macrophages abrogated by protease inhibitors

[0130] Previous studies have shown that serine proteases released by polymorphonuclear cells (PMN) after degranulation cleave the C-terminus of ProChemerin and release its chemotactic potential (Wittamer V et al. J Immunol. 2005 Jul 1;175(1):487-493). However, the anti-inflammatory effect of the peptides produced by further proteolytic processing of chemerin is novel and inventive.

[0131] Murine peritoneal macrophages (PMθ, also referred to herein as PMΦ) were cultured under various conditions: untreated; LPS (100ng / ml) and IFNγ (20ng / ml) for 15 hours; chemerin (1pM) pretreated 1 hour followed by LPS / IFNγ for 15 hours; leupeptin (protease inhibitor; 15 mg / ml) and chemerin (1 pM) for 1 hour followed by LPS / IFNγ for 15 hours; or dexamethasone (positive control ; 1 μM, pretreatment for 1 hour, followed by LPS / IFNγ, 15 hours.

[0132] Analysis of chemokine content i...

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PUM

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Abstract

This invention provides the use of one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for treatment of inflammation and/or endotoxic shock and/or treatment of wounds and/or reduction of levels of inflammatory chemokines in a subject, and one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for use in the treatment of inflammation and/or endotoxic shock, and/or wounds, or for the reduction of levels of inflammatory mediators.

Description

technical field [0001] The present invention relates to the treatment of inflammation and / or endotoxic shock and / or the reduction of the level of inflammatory chemokines, and to the combination for the treatment of inflammation and / or endotoxic shock, or for the reduction of the level of inflammatory mediators things. Background technique [0002] Inflammation is an integral part of the pathogenesis of many human and animal diseases, and also occurs as a result of physical, chemical or traumatic injury to human or animal body tissues. Typically, the immune response results in the systemic release of endogenous chemical mediators, which results in vasodilation, neutrophil migration, chemotaxis, and increased vascular permeability. Regardless of where and what causes the immune response, the causes are essentially the same. The response can be acute (transient) or can be chronic (sustained). [0003] Endotoxic shock, sometimes called septic shock, is thought to occur as a r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/04A61P29/00A61P31/00C07K7/04A61K38/08
CPCA61K38/00C07K14/47A61P1/04A61P1/16A61P11/00A61P11/02A61P11/06A61P13/12A61P17/02A61P17/04A61P17/06A61P19/02A61P21/00A61P25/00A61P27/02A61P27/16A61P29/00A61P3/10A61P31/00A61P31/04A61P31/10A61P31/12A61P31/18A61P33/00A61P37/02A61P37/06A61P37/08A61P39/00A61P39/02A61P43/00A61P5/14A61P7/04A61P7/06A61K38/08A61K38/10C07K7/06C07K7/08
Inventor 戴维·R·格里夫斯安德烈亚斯·鲁斯詹纳·L·卡什
Owner OXFORD UNIV INNOVATION LTD
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