42 results about "Chemerin" patented technology

Disclosed are method for treating diabetes, a protein for treatment of diabetes, and pharmaceutical composition comprising the same. The protein is human mature chemerin, which can be used to treat diabetes, in particular type 2 diabetes, inter alia to treat diabetes in a patient who is concurrently administered with insulin.

The invention relates to a test strip for detecting chemokine and its derivative polypeptide and a preparation method thereof, and specifically discloses a test strip for detecting chemokine, which includes a detection membrane, and the upstream of the detection membrane is provided with a The binding area of ​​the first antibody, the binding area is provided with a sample application area upstream, wherein, the detection membrane is provided with a detection area and a control area, and the control area is located downstream of the detection area; wherein the detection area is coated with a second antibody, The control region is coated with a secondary antibody containing an anti-first antibody; both the first antibody and the second antibody can specifically bind to chemokines. The test strip of the invention is convenient, fast, economical and can realize semi-quantitative.

This invention provides the use of one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for treatment of inflammation and / or endotoxic shock and / or treatment of wounds and / or reduction of levels of inflammatory chemokines in a subject, and one or more peptides derived from the C-terminal end of a Chemerin protein, or analogs or derivatives thereof for use in the treatment of inflammation and / or endotoxic shock, and / or wounds, or for the reduction of levels of inflammatory mediators.

The invention discloses a CMKLR1 antagonistic polypeptide and its derivatives and applications, specifically related to the sequence of SEQ ID No.1-17 and its derivatives, the derivatives of the binding peptide are CMKLR1 binding peptide amino acid side chain group, CMKLR1 The product obtained by conventional modification of the amino-terminal or carboxyl-terminal of the antagonistic polypeptide fragment, or the product obtained by linking a tag for polypeptide or protein detection or purification on the CMKLR1 antagonistic polypeptide; the binding peptide and its derivatives can bind CMKLR1 in vitro , by blocking the combination of chemerin and CMKLR1, it promotes the increase of cAMP concentration, inhibits the calcium influx caused by chemerin, inhibits the cell chemotaxis caused by chemerin, and can inhibit the proliferation of ovarian cancer cells, block their cell cycle, and promote the occurrence of ovarian cancer cells Apoptosis, providing effective therapeutic small molecule drugs for female reproductive diseases such as ovarian cancer.