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Application of small interfering RNA (Ribonucleic Acid) of RALA (v-ral simian leukemia viral oncogene homolog A) gene in preparing medicaments for resisting leukemia

A small interference, leukemia technology, applied in the field of medicine, can solve problems such as the lack of effective treatment options

Active Publication Date: 2010-08-25
JINAN UNIVERSITY
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Problems solved by technology

At present, there is still no effective treatment plan for CML, mainly chemotherapy

Method used

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  • Application of small interfering RNA (Ribonucleic Acid) of RALA (v-ral simian leukemia viral oncogene homolog A) gene in preparing medicaments for resisting leukemia
  • Application of small interfering RNA (Ribonucleic Acid) of RALA (v-ral simian leukemia viral oncogene homolog A) gene in preparing medicaments for resisting leukemia
  • Application of small interfering RNA (Ribonucleic Acid) of RALA (v-ral simian leukemia viral oncogene homolog A) gene in preparing medicaments for resisting leukemia

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Abstract

The invention discloses a small interfering RNA (Ribonucleic Acid) of an RALA (v-ral simian leukemia viral oncogene homolog A) gene and application thereof in preparing medicaments for resisting leukemia. The sequence of the small interfering RNA is as follows: the positive-sense strand is 5'-CGUGGAAACAUCUGCUAAATT-3', and the antisense strand is 5'-UUUAGCAGAU GUUUCCACGTA-3'. The small interfering RNA of the RALA gene can be used for preparing the medicaments for resisting the leukemia. The RALAsiRNA can suppress the growth of human leukemia k562 cells through down regulating the expression of a cancer RALA, has potential application values to oncogene treatment and is expected to be applied to the treatment of the leukemia. Moreover, on the basis of the small interfering RNA, new medicines for resisting the leukemia are developed to make a contribution to the prevention and cure of clinical leukemia.

Description

technical field The invention belongs to the field of medicine, and in particular relates to a small interfering RNA of RALA gene and its application in preparing anti-leukemia drugs. Background technique Chronic myelogenous leukemia is a malignant proliferative disease originating from pluripotent hematopoietic stem cells, accounting for about 20% to 30% of leukemia in adults, and the incidence rate of leukemia in my country is second only to acute myeloid and acute lymphoblastic lymphadenopathy. It has become a common malignant tumor that threatens people's health. At present, there is still no effective treatment plan for CML, mainly chemotherapy. In recent years, the treatment of leukemia and other tumors has entered the new era of "targeted therapy" from the era of "whole cell killing". Seeking the key "target" of tumor malignant transformation or genes closely related to tumorigenesis, and developing targeted drugs has become an important direction in the research of ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/113A61K48/00A61P35/02
Inventor 费嘉李育敏谷景义朱雪姣姚君琳林春燕黄康康李灿峰
Owner JINAN UNIVERSITY
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