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Application of compound of (E)-5-[6-hydroxy-5-(3-methyl-1-butenyl)-2-benzofuranyl] phenyl-1, 3-diol to preparation of pancrelipase inhibitor

A technology of benzofuryl and pancreatic lipase, which is applied in the field of natural compounds to prepare pancreatic lipase inhibitors, can solve problems such as no biological activity research reports, and achieve a strong inhibitory effect on pancreatic lipase

Inactive Publication Date: 2010-09-15
FUDAN UNIV +1
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Problems solved by technology

There is no research report on the biological activity of this compound

Method used

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  • Application of compound of (E)-5-[6-hydroxy-5-(3-methyl-1-butenyl)-2-benzofuranyl] phenyl-1, 3-diol to preparation of pancrelipase inhibitor
  • Application of compound of (E)-5-[6-hydroxy-5-(3-methyl-1-butenyl)-2-benzofuranyl] phenyl-1, 3-diol to preparation of pancrelipase inhibitor
  • Application of compound of (E)-5-[6-hydroxy-5-(3-methyl-1-butenyl)-2-benzofuranyl] phenyl-1, 3-diol to preparation of pancrelipase inhibitor

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Abstract

The invention relates to the application of the compound which has the chemical formula (1), in particular to the application of the compound of (E)-5-[6-hydroxy-5-(3-methyl-1-butenyl)-2-benzofuranyl] phenyl-1, 3-diol to the preparation of pancrelipase inhibitor, belonging to the technical field of the medicament. The compound of (E)-5-[6-hydroxy-5-(3-methyl-1-butenyl)-2-benzofuranyl] phenyl-1, 3-diol is separated from the smooth-leaf artocarpus. The experiment proves that the compound of (E)-5-[6-hydroxy-5-(3-methyl-1-butenyl)-2-benzofuranyl] phenyl-1, 3-diol has strong pancrelipase inhibiting activity and can be used as the leading compound for developing and preparing the novel medicament for preventing or treating clinically-common and frequently-occurring obesity and related metabolic diseases.

Description

technical field The invention belongs to the technical field of medicine, and relates to the use of a natural compound isolated from laurel wood. Specifically related to compound (E)-5-[6-hydroxyl-5-(3-methyl-1-butenyl)-2-benzofuryl]benzene-1,3-diol in the preparation of pancreatic lipase inhibitory use in pharmaceuticals. Background technique In the past 20 years, the incidence of obesity has been increasing all over the world, especially in developed countries. Due to the rapid development of the economy and the continuous improvement of living standards, the problems of insufficient exercise and relative excess energy intake have always existed in the lifestyle of modern people, which has led to the energy intake of many modern people exceeding energy consumption, and the excess energy will be Part of it is stored as fat in adipose tissue, and its accumulation can lead to obesity and related diseases, such as diabetes, cancer, heart disease, hyperlipidemia, and fatty li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P3/04A61P3/00A61P43/00
Inventor 侯爱君王贺瑶赵婷闫桂蕊
Owner FUDAN UNIV
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