Novel mangiferin calcium salts, the method for preparation and use thereof

A technology of mangiferin calcium salt and mangiferin, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, metabolic diseases, etc., can solve the problems of mangiferin solubility, bioavailability, absorption defects, etc., and achieve stable properties and high yields. high effect

Inactive Publication Date: 2013-01-02
CHANGZHOU DEZE MEDICAL SCI CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, mangiferin still has defects in solubility, bioavailability and absorption of the body.

Method used

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  • Novel mangiferin calcium salts, the method for preparation and use thereof
  • Novel mangiferin calcium salts, the method for preparation and use thereof
  • Novel mangiferin calcium salts, the method for preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0078] Preparation Example 1: Preparation of Mangiferin

[0079] 100 kg of Zhimu decoction pieces were extracted twice with 80% ethanol at 80°C, concentrated, adsorbed on a macroporous resin, washed with water, and eluted with 40% ethanol. The eluate was concentrated under reduced pressure to obtain crude mangiferin. The crude mangiferin was purified by solvent-dioxane-water recrystallization to obtain pure mangiferin. The mangiferin sample was identified with the mangiferin reference substance, and the obtained sample was determined to be mangiferin. The purity was determined by HPLC to be 98.5%. .

[0080] Compound identification:

[0081] 1 HNMR(DMSO-d 6 ) (δppm), 4.60 (1H, d, J = 9.8 Hz) is a glucose terminal proton, and it exists in the form of B-glycosidic bond; and 6.37 (1H, s), 6.86 (1H, s) and 7.39 (1H, s) 3 aromatic proton signals.

[0082] 13 CNMR(DMSO-d 6 )(δppm): 162.7(C-1), 108.4(C-2), 164.7(C-3), 94.2(C-4), 157.1(C-4a), 102.2(C-4b), 103.5(C -5), 154.9(C-6), 144.6(C-7...

Embodiment 1

[0087] Example 1: Preparation of mangiferin monosodium salt

[0088] Add 42.2g (0.1mol) of mangiferin, 1800ml of water, and 600ml of ethanol into the reactor to fully suspend, add 8.4g (0.1mol) of sodium bicarbonate to water to make a 0.5% (w / v) solution, and slowly add it to the stirring state In the suspension, react until it is clear, filter, add an appropriate amount of absolute ethanol-ethyl acetate (1:1.5v / v) to the solution, stir well, and a large amount of precipitate will precipitate, filter with suction, and dry the solid below 60°C , 31.2 g of light yellow solid mangiferin monosodium salt was obtained, and the yield was 74.0%. The purity of the sample was determined to be 98.6% by HPLC.

Embodiment 2

[0089] Example 2: Preparation of mangiferin monosodium salt

[0090] Add 42.2g (0.1mol) of mangiferin, 1800ml of water, and 900ml of ethanol into the reactor to fully suspend, add 5.30g (0.05mol) of sodium carbonate to water to make a 0.5% (w / v) solution, and slowly add to the stirred mixture In the suspension, react until it is clear, filter, add appropriate amount of acetone to the solution, stir well, a large amount of precipitation will precipitate, filter with suction, and dry the solid below 60°C to obtain 31.4g of light yellow solid mangiferin monosodium salt, yield It is 74.5%. The purity of the sample was determined to be 98.5% by HPLC.

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Abstract

The present invention relates to novel mangiferin calcium and its preparation and use. The mangiferin calcium can lower plasma insulin, glucose, lipid, also can improve the solubility and oral bioavailability of mangiferin.

Description

Technical field [0001] The present invention relates to a calcium salt of mangiferin, a preparation method thereof, and use as an insulin sensitizer for treating diabetes and its complications. Background technique [0002] Insulin resistance (IR) refers to a series of pathological and clinical manifestations caused by the decrease or loss of the responsiveness of the target organs and tissues of insulin to the biological effects of insulin. A large number of studies have shown that IR runs through the occurrence and development of type 2 diabetes and is a significant feature of type 2 diabetes. With IR as the core, it can cause hyperglycemia, hypertension, microalbuminuria, inflammation, high fibrinolytic state, abnormal lipid metabolism, endothelial dysfunction, atherosclerosis and cardiovascular disease. Therefore, by enhancing the effect of insulin and improving the sensitivity of insulin receptors, insulin sensitizers are developed to treat diabetes and its complications (d...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/04A61K31/7048A61P3/10
CPCC07H17/04
Inventor 滕厚雷吴巍林喆徐广爱
Owner CHANGZHOU DEZE MEDICAL SCI CO LTD
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