Arginine (s)-ibuprofen granules and preparation method thereof

A technology of dextro-ibuprofen and arginine, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. preparations, failure to cover up the irritating odor of drugs, and easy deliquescence of arginine ibuprofen tablets, achieving the effects of rapid dissolution, low cost and good solubility
CN101856331BActive Publication Date: 2012-07-04HAINAN HULUWA PHARMA GRP CO LTD
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Patents(China)
Current Assignee / Owner
HAINAN HULUWA PHARMA GRP CO LTD
Publication Date
2012-07-04

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Abstract

The invention discloses arginine (s)-ibuprofen granules which are prepared from the following raw materials in parts by weight: 1 part of arginine (s)-ibuprofen, 1-100 parts of fillers, 1-20 parts of adhesives, 0.2-10 parts of thickening agents and 0.1-10 parts of flavoring agents. The granules are quickly dissolved in water to form transparent liquid with good mouthfeel, are convenient to take and have high bioavailability. The preparation method is simple, dispenses with any special equipment and is suitable for industrial production.
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Description

technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to an arginine-dextroibuprofen granule and a preparation method thereof. Background technique

[0002] Ibuprofen, chemical name: 2-methyl-4-(2-methylpropyl) phenylacetic acid, IUPAC name: 2-(4-isobutylphenyl) propanoic acid, CAS No.15687-27-1, molecular formula C 13 h 18 o 2 , with a molecular weight of 206.28, is a non-steroidal anti-inflammatory drug (NSAID). It is the first profen drug used clinically and is still widely used in the world. It is recognized as one of the safest drugs in non-steroidal anti-inflammatory drugs. 1. It has analgesic, anti-inflammatory and antipyretic effects. Its mechanism of action is to reduce the synthesis of prostaglandins by inhibiting cyclooxygenase, thereby reducing tissue congestion and swelling caused by prostaglandins, and reducing the sensitivity of peripheral nerve pain. Sex, and play an antipyretic effect through the hypothal...

Claims

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