Biological endogenous magnetic particle detection device

A detection device and magnetic particle technology, which is applied in the direction of measuring device, magnetic performance measurement, magnetic variable measurement, etc., can solve the problems of lack of magnetization and demagnetization coils, and the inability to realize the detection of biological endogenous magnetic particles.

Inactive Publication Date: 2012-08-29
INST OF ELECTRICAL ENG CHINESE ACAD OF SCI
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Problems solved by technology

[0004] The Chinese patent application number is 200310122728.3 High-temperature superconducting quantum interferometer with adjustable distance liquid nitrogen metal Dewar describes a standard Dewar structure for scanning superconducting quantum interferometer microscopes. This patent lacks magnetization and demagnetization coils and cannot realize The detection of biological endogenous magnetic particles. In addition, the Dewar uses a high-temperature superconducting quantum interferometer as a magnetic sensor, and the magnetic flux sensitivity of the low-temperature superconducting quantum interferometer is three orders of magnitude different.

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Embodiment Construction

[0019] The specific implementation of the present invention will be further described below in conjunction with accompanying drawing:

[0020] The invention mainly includes: a detection unit of a low-temperature superconducting quantum interference instrument, a magnetization and demagnetization unit 3, a two-dimensional mobile platform for biological samples, a controller 10 for the mobile platform and the magnetization and demagnetization unit, a data processing system 12, and a magnetic shielding room 13. The detection unit of the low-temperature superconducting quantum interferometer includes a low-temperature non-magnetic Dewar 1 , a low-temperature DC superconducting quantum interferometer 2 , a preamplifier 4 , a low-temperature data line 5 and a gradient receiving coil 6 . The two-dimensional mobile platform for biological samples includes a mobile platform 8 and a non-magnetic sample holder 9 .

[0021] Low-temperature superconducting quantum interferometer detection ...

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Abstract

The invention discloses a biological endogenous magnetic particle detection device. A gradient receiving coil (6) is connected with an input coil of a low-temperature DC superconducting quantum interference device (2); the low-temperature DC superconducting quantum interference device (2) is connected with a preamplifier (4); and the low-temperature DC superconducting quantum interference device (2), the gradient receiving coil (6) and a low-temperature data wire (5) are packaged in a low-temperature non-magnetic Dewar (1). When DC passes through a magnetization and demagnetization unit (3), a static magnetic field is generated to magnetize a biological sample; and when AC passes through the magnetization and demagnetization unit (3), an AC magnetic field is generated to demagnetize the biological sample. A mobile platform and a magnetization and demagnetization unit controller (10) complete control signal acquisition and feedback control of the magnetization and demagnetization unit (3) and the mobile platform (8). The low-temperature non-magnetic Dewar (1), the magnetization and demagnetization unit (3), the magnetic nanoparticle-containing biological sample (7), the mobile platform (8) and a non-magnetic sample holder (9) are arranged in a magnetically shielded room (13).

Description

technical field [0001] The invention relates to a magnetic particle detection device, in particular to a device for detecting biological endogenous magnetic particles by using scanning superconducting quantum interference microscope technology combined with a magnetization demagnetization coil. Background technique [0002] At present, studies have found magnetic particles in many kinds of bacteria, animals and human brain. These magnetic particles are usually made of crystalline hematite (γ-Fe 2 o 3 ) and magnetite (small particle size Fe 3 o 4 , superparamagnetic) composition, the size of a single magnetic particle is usually between 20 nanometers and 100 nanometers. The means for detecting the magnetism of these magnetic particles is usually to measure the isothermal remanent magnetization curve by using a magnetic measurement system MPMS (manufactured by Quantum Design Corporation) equipped with a superconducting quantum interference sensor. However, this system nee...

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): G01R33/12G01R33/10
Inventor王庆蒙宋涛王明
OwnerINST OF ELECTRICAL ENG CHINESE ACAD OF SCI