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Celosia argentea L. saponin compounds and application thereof

A kind of technology of green saponin and green green glycoside, which is applied in the field of medicine and achieves the effect of simple preparation method and low cost

Active Publication Date: 2013-04-03
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present inventor has isolated the saponins components Qingqi glycoside A, glucoside B, glucoside C and glycoside D from the fruit of Qingzizi, and applied for a patent (see ZL200610026789.3 and 200910053042.0 for details), but has not been extracted from Qingzizi so far. The total saponins III of quinces and the isolated glycosides C 1 , Qingruoside D 1 , Qingruoside E, Qingruoside F, and Qingruoside G

Method used

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  • Celosia argentea L. saponin compounds and application thereof
  • Celosia argentea L. saponin compounds and application thereof
  • Celosia argentea L. saponin compounds and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1. Preparation of total saponins III and compound Qingruoside C 1 、D 1 , E, F, G

[0020] Take 50kg of green fennel seeds from Bozhou, Anhui, crush them, soak them in 50L of water at room temperature for 24 hours, then extract them by percolating at a rate of 20L per hour, then collect 250L of water percolating liquid, concentrate the extract under reduced pressure to obtain a concentrated solution, and pass the concentrated solution through AB-8 macroporous resin column, sequentially eluted with water, 30% ethanol, 45% ethanol, 60% ethanol and 95% ethanol gradient, collected 30% ethanol, 45% ethanol and 60% ethanol eluent respectively and depressurized Concentrate and dry to obtain 55 g of total saponins I, 25 g of total saponins II and 150 g of total saponins III of fennel successively. Among them, the main components of the total saponins II of A. chinensis are A. chinensis A, A. chinensis B, A. chinensis C and A. chinensis D (see ZL200610026789.3 and 20091...

Embodiment 2

[0023] Example 2. Preparation of total saponins III and compound quincenosides C 1 、D 1 , E, F, G

[0024] Take 50kg of green figs from Bozhou, Anhui, crush them, soak them in 50L of 50% ethanol at room temperature for 24 hours, extract by percolation at a rate of 20L per hour, collect 250L of water percolation liquid, and concentrate the extract under reduced pressure to obtain a concentrated solution. The solution was passed through a D101 macroporous resin column, followed by gradient elution with water, 30% ethanol, 45% ethanol, 60% ethanol and 95% ethanol, and the eluents of 30% ethanol, 45% ethanol and 60% ethanol were collected respectively and subtracted Concentrate under pressure and dry to obtain 155 g of total saponins I, 125 g of total saponins II and 270 g of total saponins III of Qingren successively.

[0025] The method for preparing quintillin E, F and G from quintillin total saponins I was the same as that in Example 1, and 4.5 g of quintillin E, 3.8 g of sc...

Embodiment 3

[0027] Example 3. Preparation of total saponins III and compound Qingguiside C 1 、D 1 , E, F, G

[0028] Take 50kg of green fennel seeds from Bozhou, Anhui, crush them, soak them in 50L of 70% ethanol at room temperature for 24 hours, then extract them by percolation at a speed of 20L per hour, then collect 250L of water percolation liquid, and concentrate the extract under reduced pressure to obtain a concentrated solution. The solution was passed through the NKA-9 macroporous resin column, followed by gradient elution with water, 30% ethanol, 45% ethanol, 60% ethanol and 95% ethanol, and the 30% ethanol, 45% ethanol, and 60% ethanol eluents were collected respectively Concentrate under reduced pressure and dry to obtain 95 g of total saponins I, 75 g of total saponins II and 150 g of total saponins III.

[0029]The method for preparing quintillin E, F and G from total quintillin saponins I was the same as in Example 1, and 3.5 g of quintillin E, 2.8 g of scallopin F, and 3...

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Abstract

The invention relates to the technical field of medicine, in particular to Celosia argentea L. total saponin III and Celosia argentea L. saponin novel compounds (Celosin C1, Celosin D1, Celosin E, Celosin F and Celosin G) which are extracted from Celosia argentea L. The chemical structural formulas of the five Celosia argentea L. saponin compounds are shown in the specification. Animal experiments prove that the Celosia argentea L. total saponin III and Celosia argentea L. saponin novel compounds (C1, D1, E, F and E) are have activity of preventing and treating hepatopathy, heart cerebrovascular diseases, metabolic disease, dementia, tristimania or angst, and the compounds provided by the invention are simple in preparation method and low in cost. The invention provides new medicament sources for hepatopathy heart cerebrovascular disease, metabolic disease, dementia, tristimania or angst.

Description

technical field [0001] The present invention relates to the technical field of medicine, and relates to a Celosia argentea total saponin III extract extracted from Celosia argentea L.'s dry mature seeds Celosia argentea (Semen Celosiae) and five new compounds of Celosia argentea L. Aquinoside C 1 (Celosin C 1 ), cyanoside D 1 (Celosin D 1 ), Celosin E (Celosin E), Celosin F (Celosin F) and Celosin G (Celosin G) and their use in the preparation of drugs for preventing and treating liver diseases, cardiovascular and cerebrovascular diseases, metabolic diseases, dementia, depression or anxiety in the application. Background technique [0002] Semen Celosiae is the dry mature seed of Celosia argentea L. in the family Amaranthcea. Fructus Chinensis is bitter in taste and slightly cold in nature. It has the effects of clearing the liver, improving eyesight, dispelling wind-heat, lowering blood pressure and anti-inflammation. It is often used in the treatment of conjunctival ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00C07H15/256A61K36/21A61K31/704A61K31/56A61P1/16A61P9/00A61P3/00A61P25/28A61P25/22A61P25/24
Inventor 郭美丽武清斌孙振亮
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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