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Compound and crystals thereof

A technology of compounds and crystals, applied in the field of pharmacy, can solve the problems of non-conformity with drug characteristics, low biological activity, high toxicity, etc.

Active Publication Date: 2011-05-25
HUTCHISON MEDIPHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in further research, it was found that in a series of compounds disclosed by it, there are some defects, or problems such as small biological activity, high toxicity, or pharmacokinetics, which do not meet the characteristics as drugs, so it is necessary to Explore more effective KDR inhibitors with better pharmaceutical properties

Method used

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  • Compound and crystals thereof
  • Compound and crystals thereof
  • Compound and crystals thereof

Examples

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Embodiment 1

Embodiment 2

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Abstract

The invention discloses a pyrimidine compound of a structural formula A. The structural formula A is shown below. The pyrimidine compound can be used for preparing medicaments for treating diseases associated with vasculogenesis, in particular medicaments for treating tumor, age-related macular degeneration or autoimmune diseases.

Description

technical field The invention belongs to the field of pharmacy and provides a pyrimidine compound N-[2-(dimethylamino)ethyl]-[3-[4-(2-methyl-1H-indole-5-oxyl)pyrimidine- 2-Amino]phenyl]methanesulfonamide and its medicinal use and crystal form, in particular to a kinase-inserted-region receptor (KDR) inhibitor for treating diseases related to angiogenesis. Background technique Angiogenesis is the physical process of growing new blood vessels from pre-existing blood vessels. It often occurs when a healthy body uses it to heal a wound, such as restoring blood flow to injured tissue in the hand. Excessive vascular proliferation can be initiated by some specific pathological conditions, such as tumors, age-related macular degeneration (Age-related Macular Degeneration, AMD), rheumatoid arthritis, psoriasis and so on. Therefore, under these conditions, new blood vessels often nourish pathological tissues and destroy normal tissues. For example, in tumors, new blood vessels can a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D403/12A61K31/513A61P35/00A61P27/02A61P29/00A61P35/02
CPCC07D403/12A61P27/02A61P29/00A61P35/00A61P35/02A61P43/00A61P9/00A61K31/506
Inventor 苏慰国张维汉贾红崔玉敏任永欣赛杨吴振平李文姬邵江勇
Owner HUTCHISON MEDIPHARMA LTD
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