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Extraction method for increasing liquiritigenin content in glycyrrhizae radix et rhizoma or glycyrrhizae radix extract

A technology of licorice extract and glycyrrhizin, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of difficult removal of DMSO and poor purity of glycyrrhizin, and achieve the effect of simplifying the steps

Inactive Publication Date: 2011-06-29
DAE WON PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] However, since DMSO with a high melting point is difficult to remove in this method, a lot of work such as checking for residual solvents needs to be done. When using HCl for acid hydrolysis, problems arise. Due to the slow hydrolysis reaction, time-consuming acid hydrolysis is inevitable. The purity of the produced glycyrrhizin is not good

Method used

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  • Extraction method for increasing liquiritigenin content in glycyrrhizae radix et rhizoma or glycyrrhizae radix extract

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Preparation of Liquiritigenin 1

[0048] (1) Preparation of licorice extract containing liquiritin

[0049] After purchasing licorice from an oriental drug dealer and accurately classifying it, it is divided into small pieces (licorice segments) for use. Licorice root contains less than 1% liquiritin. Add 800 ml of about 80% to about 90% methanol to about 100 g of licorice section, and heat and stir at about 85° C. for about 8 hours. Subsequently, it was cooled and filtered, and then concentrated under reduced pressure to obtain an extract containing about 25.8 g of liquiritin.

[0050] 1 H NMR (CD 3 OD, 300MHz) δ7.61 (1H, d, 8.6Hz) 7.08 (2H, d, 8.4Hz) 6.81 (2H, d, 8.4Hz) 6.49 (1H, dd, 8.6Hz), 6.37 (1H, d, 2.4 Hz), 5.41 (1H, dd, 13.2, 3.1), 5.37 (2H, dd, 13.0, 2.9Hz), 3.49 (3H, t, 2.4Hz), 3.05 (1H, dd, 17.0, 13.0), 2.68 (1H, dd, 17.0, 2.9).

[0051] In the obtained licorice extract, the content of liquiritin was measured according to the following method. Spec...

Embodiment 2

[0066] Preparation of Liquiritigenin 2

[0067] About 23 g of a dark brown substance (licyrrhizin content: about 11.2%) was obtained by the same method as in Example 1, except that about 80% of ethanol was added to the licorice to prepare an extract.

Embodiment 3

[0068] Preparation of Liquiritigenin 3

[0069] Adopt the same method as Example 1 to obtain about 23g of dark brown matter (licyrrhizin content: about 11.8%), the difference is that after adding about 80% methanol to the licorice to obtain the extract, then add about 100% to the extract. % methanol to obtain a liquiritin-containing extract (about 2.9%).

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Abstract

Disclosed herein is an extraction method for increasing liquiritigenin content in Glycyrrhizae Radix et Rhizoma or Glycyrrhizae radix extract, the method comprises: using water, an organic solvent, or a mixed solvent of water and the organic solvent to Glycyrrhizae Radix et Rhizoma to extract a product containing liquiritin (Step 1); and introducing water, an organic solvent, or a mixed solvent of water and the organic solvent into the product containing liquiritin extracted in Step 1, adding acid or base into the solution, and hydrolyzing the mixture to prepare a product containing liquiritigenin (Step 2).

Description

technical field [0001] The invention relates to an extraction method for increasing the content of glycyrrhizin in licorice or licorice extract. Background technique [0002] Generally, licorice is a perennial plant belonging to the Rosaceae Fabaceae, its root is reddish brown, grows in a deep soil layer, and its angular stem grows vertically to about 1 m to about 1.5 m. Its leaves are obliquely oval with pointed tips. The leaves are about 2 cm to about 5 cm long and about 1 cm to about 3 cm wide, without any inner lobes (lacinia). Its flowers are similar to those of soybeans, and they bloom indigo in summer in a raceme. [0003] In keeping with the old idiom, "the licorice of the Eastern pharmacy," this plant is an herb widely used in Eastern pharmaceutical practice. According to the pharmacological action of licorice, it binds toxic substances in the liver and detoxifies the liver, and is useful for treating drug addiction, hepatitis, urticaria, dermatitis, eczema, etc....

Claims

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Application Information

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IPC IPC(8): A61K36/484A61K31/352A61P39/02
CPCA61K36/484A61K2236/333A61P25/28
Inventor 郑灿圭孙世一金弘起金亨善
Owner DAE WON PHARMA
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