Application of triacetyl-3-hydroxyphenyladenosine (THPA) in pharmacy

A kind of hydroxyphenyladenosine and triacetyl technology, applied in the application field of cordycepin derivative triacetyl-3-hydroxyphenyladenosine in pharmacy

Inactive Publication Date: 2011-07-20
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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However, there is no report about the effect of tr

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  • Application of triacetyl-3-hydroxyphenyladenosine (THPA) in pharmacy
  • Application of triacetyl-3-hydroxyphenyladenosine (THPA) in pharmacy
  • Application of triacetyl-3-hydroxyphenyladenosine (THPA) in pharmacy

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Experimental program
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Embodiment 1

[0019] 1. Materials and methods

[0020] 1.1 Animals and experimental design

[0021] 41 male apoE from the Institute of Experimental Animals, Chinese Academy of Medical Sciences - / - Mice were used in this experiment. At the age of 5 weeks, the mice were randomly divided into 4 groups, model group (n=11); THPA treatment group (2.5-10 mg / kg / d) (n=10, 10 mice in each group). The experimental animals in the 4 groups were all fed a high-fat diet (15.8% fat and 1.25% cholesterol) that promoted atherosclerosis, and the animals and high-fat diet in this experimental group were purchased from Beijing Huafukang Biotechnology Co., Ltd.), adding solvent or THPA for 6 weeks. Both the solvent and THPA were given to the experimental animals by intragastric administration every day.

[0022] 1.2 Plasma analysis

[0023] After 6 weeks of treatment, fasted for 12 hours and anesthetized, blood was collected from the medial canthal vein. Plasma total cholesterol (TC), high-density lipoprot...

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Abstract

The invention relates to application of triacetyl-3-hydroxyphenyladenosine (THPA) in preparing a medicament for treating atherosclerosis. The invention has the advantages of providing new application of the THPA, disclosing and quantitatively analyzing various activities of the THPA on resisting atherosclerosis lesion for the first time, providing new knowledge on the anti-atherosclerosis function of the THPA, and indicating that use of the THPA provides a new treatment strategy for treating the atherosclerosis.

Description

technical field [0001] The invention relates to a new application of a cordycepin derivative, in particular to the application of a cordycepin derivative triacetyl-3-hydroxyphenyl adenosine in pharmacy. Background technique [0002] Atherosclerosis is a chronic vascular inflammatory disease caused by multiple factors that can lead to cardiovascular diseases. Inflammatory processes in the arterial wall mediate the initiation and progression of atherosclerosis. Multiple inflammatory factors and genes are involved in various stages of atherosclerotic lesion process. Monocytes invade the damaged area of ​​the arterial wall and proliferate and differentiate into macrophages leading to the formation of atherosclerotic plaques. In recent years, the treatment strategy of atherosclerosis has focused on anti-inflammation and reducing the infiltration of cholesterol into the arterial wall by reducing plasma low-density lipoprotein cholesterol (LDL-C), thereby inhibiting the formation...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P9/10
Inventor 秦树存赵振美宋国华田华于杨
Owner TAISHAN MEDICAL UNIV
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