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Choline alfoscerate injection preparation as well as preparation method and detection method thereof

A technology of choline alfoscerate and a detector, which is applied in the field of medicine to achieve the effect of improving detection sensitivity and reliability

Inactive Publication Date: 2011-08-03
CHINESE MEDICINES GUANGZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But each has its own defects, and when applied to sensitive cerebrovascular, any side effects may have fatal consequences

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Weigh 60 grams of choline alfoscerate and 1.5 grams of glycerol and add water for injection to dissolve to 100 milliliters. Stir to combine. Divide 4ml into 5ml vials, sterilize, inspect by light, test content, related substances and other items, and store in airtight.

Embodiment 2

[0025] Weigh 180 grams of choline alfoscerate, 4.5 grams of glycerol, and 0.5 grams of mannitol, and add water for injection to dissolve to 100 milliliters. Stir to combine. Divide 4ml into 5ml vials, sterilize, inspect by light, test content, related substances and other items, and store in airtight.

Embodiment 3

[0027] Weigh 100 grams of choline alfoscerate and 0.5 grams of glycerol and add water for injection to dissolve to 100 milliliters. Stir to combine. Divide 4ml into 5ml vials, sterilize, inspect by light, test content, related substances and other items, and store in airtight.

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PUM

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Abstract

The invention relates to the field of medicines, in particular to a composition containing choline alfoscerate. The composition is characterized by being prepared from the following components: 5-20 percent of choline alfoscerate, 0-5 percent of glycerin, a suitable amount of other accessories and the balance of injection water; the content and the impurities of the injection are detected by adopting a high-pressure liquid-phase chromatogram; and the total amount of the impurities is controlled to be not more than 2 percent. The choline alfoscerate is clinically used for treating patients with senile dementia and cerebral apoplexy.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a new drug for treating senile dementia and cerebral apoplexy patients. Background technique [0002] As we all know, there are many drugs clinically used in the treatment of senile dementia and stroke patients in China. But each has its own defects, and when applied to sensitive cerebrovascular, any side effects may have fatal consequences. Choline alfosate is an intermediate of phospholipid metabolism that occurs naturally in the human body. It is structurally composed of choline, glycerol, and phosphoric acid. It is a major preservation form of choline, which exists in cells and throughout the human body. It is recognized as choline Therefore, the toxicity of this product is very low, and adverse reactions in clinical use abroad are rare. [0003] Due to their good efficacy and safety, Choline Alfosate Injection and Capsules have been marketed in many foreign countries. Contents of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K31/685A61K47/10A61P9/10A61P25/00A61P25/28G01N30/02G01N30/74
Inventor 赵志明
Owner CHINESE MEDICINES GUANGZHOU
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