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Apigenin amorphous compound and preparation method thereof

A technology of amorphous matter and apigenin, which is applied in the field of medicine and can solve the problem of low solubility of apigenin crystals

Inactive Publication Date: 2012-03-07
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] The purpose of the present invention is to provide a preparation method of apigenin amorphous substance, solve the problem of low solubility of apigenin crystals, improve its bioavailability, and make it more effectively play a therapeutic role

Method used

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  • Apigenin amorphous compound and preparation method thereof
  • Apigenin amorphous compound and preparation method thereof
  • Apigenin amorphous compound and preparation method thereof

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Embodiment Construction

[0019] The invention provides a preparation method of apigenin superfine or nanoscale amorphous solid particles, specifically comprising:

[0020] (1) provide a good solvent solution comprising apigenin and a suitable anti-solvent;

[0021] (2) The specific methods for preparing amorphous apigenin are: antisolvent-high pressure homogenization-spray drying method, antisolvent-high pressure homogeneity-freeze drying method, supercritical fluid antisolvent technology,

[0022] (3) collecting the amorphous superfine or nanoscale apigenin powder obtained in step (2).

[0023] The apigenin includes all crystal forms of apigenin currently existing.

[0024] Dissolving apigenin in an organic solvent refers to forming a clear solution of apigenin in an organic solvent. In the apigenin solution of the present invention, apigenin can exist in any suitable concentration, as long as it can meet the requirement of dissolution.

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Abstract

The invention discloses a method for preparing an amorphous compound with apigenin and apigenin powder particles prepared by the method. The method is characterized in that technologies such as anti-solvent, spray drying, high-pressure homogenization and supercritical fluid are adopted to realize the preparation of amorphous apigenin, particularly the preparation of ultrafine or nanoscale amorphous apigenin particles with controllable particle size and narrow particle size distribution. As the apigenin prepared by the method is amorphous powder with controllable particle size and narrow particle size distribution, the amorphous compound is stable to temperature, light and oxygen, and can be stored easily and be used to prepare pharmaceutical preparations conveniently. Compared with apigenin crystals, the solubility of the apigenin amorphous compound is greatly increased, thus the bioavailability can be increased.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a bioavailable amorphous apigenin and a preparation method thereof. Background technique [0002] Compositae plant apigenin is a kind of natural plant flavonoids, trihydroxyflavone aglycone, which is widely distributed in the leaves and stems of dozens of fiber plants in nature in the form of plant yellow pigments, such as celery leaves, stems, sweet potato Chrysanthemum, mother chrysanthemum, whole herb of Tibetan snow lotus, whole herb of breviscapus, pigeonpea, privet, loofah leaves, root chrysanthemum, apple, clove, etc., the main source of which is the leaf and stem of umbelliferous plant parsley , It has been reported in the literature that the apigenin extracted from celery is as high as 17% of the total amount of flavonoids extracted. In addition, chemical synthesis is also possible, the method is very mature, and pure products can be obtained. [0003] Pur...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40
CPCY02P20/54
Inventor 张建军刘大鹏黄燕婷高缘
Owner CHINA PHARM UNIV
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