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Anticancer drug composition

An anti-cancer drug and composition technology, applied in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., can solve the problems of strong digestive tract adverse reactions and unbearable continuous treatment for patients, and achieve a significant synergistic anti-cancer effect. Anticancer activity, low toxicity effect

Active Publication Date: 2012-03-14
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the short-term curative effect has been improved, many patients cannot afford continuous treatment due to the strong adverse reactions in the digestive tract

Method used

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  • Anticancer drug composition
  • Anticancer drug composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 pharmaceutical composition microemulsion preparation of the present invention

[0021] Arctigenin 0.125g

[0022] Camptothecin 10g

[0023] peppermint oil 35g

[0024] Polyoxyethylene-23-lauryl ether 60g

[0025] 1,2-propanediol 30g

[0026] Preparation process: Weigh the prescription amount of peppermint oil, polyoxyethylene-23-lauryl ether, and 1,2-propylene glycol, mix and stir evenly, then add arctigenin and camptothecin to dissolve, and ultrasonic treatment can also be used to speed up the dissolution. The clarified concentrated solution is the arctigenin and camptothecin microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 15nm.

Embodiment 2

[0027] Embodiment 2 pharmaceutical composition microemulsion preparation of the present invention

[0028] Arctigenin 10g

[0029] Camptothecin 0.1g

[0030] Hydrogenated Coco Glycerides 5g

[0031] Lauroyl PEG-32-Glyceride 20g

[0032] 1,2-propanediol 5g

[0033] Polyethylene glycol 3350 20g

[0034]Preparation process: Weigh the prescription amount of hydrogenated cocoglyceride, lauroyl polyethylene glycol-32-glyceride, 1,2-propylene glycol, polyethylene glycol 3350, mix and stir evenly, then add arctigenin and camptophyllum Alkali dissolution, ultrasonic treatment can also be used to speed up the dissolution, and a clear concentrated solution is obtained, which is the arctigenin and camptothecin microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 40nm.

Embodiment 3

[0035] Embodiment 3 pharmaceutical composition microemulsion preparation of the present invention

[0036] Arctigenin 10g

[0037] Camptothecin 5g

[0038] peppermint oil 35g

[0039] Polyoxyethylene-23-lauryl ether 60g

[0040] 1,2-propanediol 30g

[0041] The preparation process is the same as in Example 3. The particle size was measured by a laser particle size analyzer, and the average particle size was 36nm.

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Abstract

The invention belongs to the field of medicine, and specifically relates to an anticancer drug composition. The anticancer drug composition contains arctigenin and camptothecine drugs. The camptothecine drugs of the present invention comprise camptothecine, hydroxy camptothecine or nitrocamptothecine. The present invention provides a microemulsion preparation containing the drug composition and an injection containing the drug composition. Compared to the single drug, the drug composition of the present invention provides a synergistic effect for inhibition of non-small cell lung cancer.

Description

technical field [0001] The invention relates to an anticancer drug composition, in particular to a drug composition containing arctigenin and camptothecin anticancer drugs. Background technique [0002] Cancer is one of the major diseases that seriously affect human health and threaten human life. Together with cardiovascular and cerebrovascular diseases and accidents, cancer constitutes the top three causes of death in all countries in the world today. Therefore, the World Health Organization and the health departments of governments of various countries have listed conquering cancer as a top priority. There are three main ways to treat cancer in the world. One is to use surgical resection to remove the diseased tissue to prevent the spread of cancer cells; the other is to use chemotherapy or radiotherapy to kill cancer cells; the third is to use drugs to treat it. Adopt the method for surgical excision to increase patient's misery, hurt its vitality, and expense is huge....

Claims

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Application Information

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IPC IPC(8): A61K31/4745A61K31/365A61K9/107A61P35/00
Inventor 赵志全
Owner SHANDONG NEWTIME PHARMA
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