Anticancer drug composition
An anti-cancer drug and composition technology, applied in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., can solve the problems of strong digestive tract adverse reactions and unbearable continuous treatment for patients, and achieve a significant synergistic anti-cancer effect. Anticancer activity, low toxicity effect
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Embodiment 1
[0020] Embodiment 1 pharmaceutical composition microemulsion preparation of the present invention
[0021] Arctigenin 0.125g
[0022] Camptothecin 10g
[0023] peppermint oil 35g
[0024] Polyoxyethylene-23-lauryl ether 60g
[0025] 1,2-propanediol 30g
[0026] Preparation process: Weigh the prescription amount of peppermint oil, polyoxyethylene-23-lauryl ether, and 1,2-propylene glycol, mix and stir evenly, then add arctigenin and camptothecin to dissolve, and ultrasonic treatment can also be used to speed up the dissolution. The clarified concentrated solution is the arctigenin and camptothecin microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 15nm.
Embodiment 2
[0027] Embodiment 2 pharmaceutical composition microemulsion preparation of the present invention
[0028] Arctigenin 10g
[0029] Camptothecin 0.1g
[0030] Hydrogenated Coco Glycerides 5g
[0031] Lauroyl PEG-32-Glyceride 20g
[0032] 1,2-propanediol 5g
[0033] Polyethylene glycol 3350 20g
[0034]Preparation process: Weigh the prescription amount of hydrogenated cocoglyceride, lauroyl polyethylene glycol-32-glyceride, 1,2-propylene glycol, polyethylene glycol 3350, mix and stir evenly, then add arctigenin and camptophyllum Alkali dissolution, ultrasonic treatment can also be used to speed up the dissolution, and a clear concentrated solution is obtained, which is the arctigenin and camptothecin microemulsion concentrate. The particle size was measured by a laser particle size analyzer, and the average particle size was 40nm.
Embodiment 3
[0035] Embodiment 3 pharmaceutical composition microemulsion preparation of the present invention
[0036] Arctigenin 10g
[0037] Camptothecin 5g
[0038] peppermint oil 35g
[0039] Polyoxyethylene-23-lauryl ether 60g
[0040] 1,2-propanediol 30g
[0041] The preparation process is the same as in Example 3. The particle size was measured by a laser particle size analyzer, and the average particle size was 36nm.
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