Pharmaceutical composition for treating Alzheimer disease (AD), and preparation method and application thereof

A technology for Alzheimer's disease and a composition, applied in the field of traditional Chinese medicine, can solve the problems of unclear mechanism of action of Alzheimer's disease

Inactive Publication Date: 2012-03-21
张占军
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, from the perspective of modern medical theory, the mechanism of action of these traditional Chinese medicines in the treatment of senile dementia is still unclear. Whether their Chinese med

Method used

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  • Pharmaceutical composition for treating Alzheimer disease (AD), and preparation method and application thereof
  • Pharmaceutical composition for treating Alzheimer disease (AD), and preparation method and application thereof
  • Pharmaceutical composition for treating Alzheimer disease (AD), and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0151] Embodiment 1: preparation

[0152] The preparation method of Heqi polysaccharide is:

[0153] Radix Radix Radix Radix Radixe root is crushed, add 10 times the amount of water by weight, and add 1% cellulase, adjust the pH to 5, decoct 3 times, 2 hours each time, filter, and collect the filtrate. Adjust the pH of the filtrate to neutral, concentrate to 60°C and measure the relative density above 1.20, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, discard the supernatant, collect the precipitate by centrifugation, wash the precipitate twice with ethanol, freeze-drying to obtain Radix Polysaccharide;

[0154] The preparation method of rhodiola rosea extract is:

[0155] Grind Rhodiola rosea, add 12 times the weight of water and soak for 12 hours, filter, collect the filtrate, add ethanol to make the alcohol content reach 70%, let it stand for 5 hours, centrifuge to collect the precipitate, wash the precipitate twice with absolute ethanol, ...

Embodiment 2

[0156] Embodiment 2: pharmaceutical composition of the present invention

[0157] The preparation method of Heqi polysaccharide is:

[0158] Radix Radix Radix Radix Radixe root is crushed, add 10 times the amount of water by weight, and add 1% cellulase, adjust the pH to 5, decoct 3 times, 2 hours each time, filter, and collect the filtrate. Adjust the pH of the filtrate to neutral, concentrate to 60°C and measure the relative density above 1.20, add ethanol to make the alcohol content reach 60%, let it stand for 24 hours, discard the supernatant, collect the precipitate by centrifugation, wash the precipitate twice with ethanol, freeze-drying to obtain Radix Polysaccharide;

[0159] The preparation method of rhodiola rosea extract is:

[0160] Grind Rhodiola rosea, add 14 times the weight of water and soak for 14 hours, filter, collect the filtrate, add ethanol to make the alcohol content reach 70%, let it stand for 5 hours, centrifuge to collect the precipitate, wash the p...

Embodiment 3

[0162] Embodiment 3: pharmaceutical composition of the present invention

[0163] The preparation method of Heqi polysaccharide is:

[0164] Radix Radix Radix Radix Radixe root is crushed, add 9 weight times of water, and add 1% of cellulase, adjust the pH to 5, decoct 4 times, each time for 1.5 hours, filter, collect the filtrate, adjust the pH of the filtrate to neutral, Concentrate to 60°C and measure the relative density above 1.20, add ethanol to make the alcohol content reach 60%, let it stand for 20 hours, discard the supernatant, centrifuge to collect the precipitate, wash the precipitate twice with ethanol, and freeze-dry to obtain Astragalus polysaccharide .

[0165] The preparation method of rhodiola rosea extract is:

[0166] Rhodiola is crushed, add 8 times the weight of water and soak for 15 hours, filter, collect the filtrate, add ethanol to make the alcohol content reach 70%, let it stand for 6 hours, centrifuge to collect the precipitate, wash the precipitat...

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Abstract

The invention discloses a composition of extractives of hedysarum polysaccharide and rhodiola rosea, a preparation method thereof and application of compatibility of the same in preparing medicines for treating AD. The compatibility of the extractives of hedysarum polysaccharide and rhodiola rosea in the invention can remarkably protect SH-SY5Y cells from being damaged by Abeta25-35 and increase the viability of the SH-SY5Y cells; according to results of Morris water maze tests, it is revealed that the extractives of hedysarum polysaccharide and rhodiola rosea can substantially enhance learning and memory ability and cognitive impairment of AD model rats; according to results of further detection, the compatibility of the extractives of hedysarum polysaccharide and rhodiola rosea enables the level of glucose metabolism in brains of the AD model rats to recover, which indicates that the compatibility of the extractives of hedysarum polysaccharide and rhodiola rosea has the effect of treating AD and has a remarkable effect.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition for treating Alzheimer's disease, a preparation method and application thereof, and belongs to the field of traditional Chinese medicine. technical background: [0002] Alzheimer's disease (Alzeimer's disease, AD) is a common neurodegenerative disease in the elderly, commonly known as senile dementia or Alzheimer's disease. The clinical feature is progressive cognitive dysfunction, and in the late stage of the disease, the patient cannot take care of himself. At present, there are more than 20 million elderly people in the world suffering from Alzheimer's disease, which seriously endangers the physical and mental health of middle-aged and elderly people, but the pain and burden brought to patients and their families is much higher than the above two diseases. It has become a modern society, One of the urgent problems to be solved in economy, medicine and family. There are 24 million patients in t...

Claims

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Application Information

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IPC IPC(8): A61K36/41C12P19/04A61P25/28A61K31/715
Inventor 张占军王永炎王燕平谢宁马涛
Owner 张占军
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