Medicinal composition for treating chronic cough of children and its preparation method

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of unfavorable quality control, excessive dosage, easy mildew and bacterial contamination, etc., and achieve significant economic and social benefits, reduced doses for patients, and improved bioavailability

Active Publication Date: 2013-06-05
津药达仁堂集团股份有限公司达仁堂制药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The preparation method of the drug is simple, but the original formulation is a honeyed pill, which is prone to mildew and bacterial contamination, which is not conducive to quality control
It is inconvenient for patients to take and carry, the taste is not good, each pill weighs 3 grams, and the dosage of each dose is too large, children have difficulty swallowing, and the patient's acceptance is poor
And the absorption process from oral administration to the gastrointestinal tract is slow

Method used

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  • Medicinal composition for treating chronic cough of children and its preparation method
  • Medicinal composition for treating chronic cough of children and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation of Chinese medicine extract

[0025] 1. Prescription: Gypsum 400g, Loquat Leaf 200g, Bamboo Ru 200g, Mulberry Leaf 200g, French Pinellia 100g, Coltsfoot Flower 100g, Mulberry Bark 100g, Scapula vulgaris 100g, Acorus calamus 20g, Pumice (calcined) 100g, Lotus Fragrant 50g, perilla seed (fried) 100g, honeysuckle 50g, bitter almond (fried) 100g, agarwood 20g, silkworm (fried) 100g, ephedra 6g.

[0026] 2. Manufacturing method:

[0027] Weigh the raw materials according to the raw material ratio; Tinglizi, Huoxiang, Perilla Seed (stir-fried), Honeysuckle, Bitter Almond (stir-fried), Agarwood 10 times and 8 times the volume percentage of ethanol with a concentration of 60% Alcohol extraction 2 times, 2 hours each time, combine the alcohol extracts and concentrate to a relative density of 1.05 at 50-60°C to obtain concentrated liquid A; the rest of the medicinal flavor is extracted twice with 10 times the amount of water, 2 hours each time , The water extrac...

Embodiment 2

[0028] Example 2: Preparation of Chinese medicine extract

[0029] 1. Prescription: Gypsum 400g, Loquat Leaf 200g, Bamboo Ru 200g, Mulberry Leaf 200g, French Pinellia 100g, Coltsfoot Flower 100g, Mulberry Bark 100g, Scapula vulgaris 100g, Acorus calamus 20g, Pumice (calcined) 100g, Lotus Fragrant 50g, perilla seed (fried) 100g, honeysuckle 50g, bitter almond (fried) 100g, agarwood 20g, silkworm (fried) 100g, ephedra 6g.

[0030] 2. Manufacturing method:

[0031] Weigh each raw material according to the raw material ratio; Tinglizi, Huoxiang, Perilla Seed (fried), Honeysuckle, Bitter Almond (fried), Agarwood 8 times and 6 times the volume percentage of ethanol with a concentration of 70% Alcohol extraction 2 times, 1.5 hours each time, combine the alcohol extracts and concentrate to a relative density of 1.05 at 50-60℃ to obtain concentrated liquid A; extract the rest of the medicinal flavor with water twice, and extract with 10 times the amount of water for the first time 2 Hours, ...

Embodiment 3

[0032] Example 3: Preparation of Chinese Medicine Extract

[0033] 1. Prescription: Gypsum 400g, Loquat Leaf 200g, Bamboo Ru 200g, Mulberry Leaf 200g, French Pinellia 100g, Coltsfoot Flower 100g, Mulberry Bark 100g, Scapula vulgaris 100g, Acorus calamus 20g, Pumice (calcined) 100g, Lotus Fragrant 50g, perilla seed (fried) 100g, honeysuckle 50g, bitter almond (fried) 100g, agarwood 20g, silkworm (fried) 100g, ephedra 6g.

[0034] 2. Manufacturing method:

[0035] Weigh the raw materials according to the raw material ratio; Tinglizi, Huoxiang, Perilla Seed (stir-fried), Honeysuckle, Bitter Almond (stir-fried), Agarwood Extract 2 times with 10 times the volume percentage of 60% ethanol , 1.5 hours each time, combine the alcohol extracts and concentrate to a relative density of 1.06 at 50-60℃ to obtain concentrated liquid A; extract the rest of the medicinal flavor with 10 times the amount of water for 2-3 times, 1.5 hours each time, combine The water extract is concentrated to a relat...

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Abstract

Belonging to the field of modernization of traditional Chinese medicines, the invention discloses a medicinal composition for treating chronic cough of children and its preparation method. The active components of the medicinal composition for treating chronic cough of children are prepared by the following raw materials by weight: 400 parts of gypsum, 200 parts of loquat leaves, 200 parts of bamboo shavings, 200 parts of mulberry leaves, 100 parts of rhizoma pinellinae praeparata, 100 parts of tussilago farfara, 100 parts of mulberry bark, 100 parts of semen lepidii, 20 parts of acorus gramineus, 100 parts of pumice (calcined), 50 parts of wrinkled gianthyssop herbs, 100 parts of perilla seeds (stir-fried), 50 parts of honeysuckle stems, 100 parts of bitter apricot kernels (stir-fried), 20 parts of agilawood, 100 parts of stiff silkworms (stir-fried), and 6 parts of ephedra. The medicinal composition of the invention has the advantages of: stable and controllable quality, substantially improved curative effect compared with existing sold preparation forms, reduced taking dosage by patients, enhanced bioavailability, as well as obvious economic and social benefits.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating chronic cough in children and a preparation method thereof, belonging to the field of modernization of traditional Chinese medicine. Background technique [0002] Persistent cough in children is a common clinical disease, characterized by recurring coughs and prolonged non-healing. Seriously affect the health and growth of children. Coughing is mostly a disease of the lung meridian, but it is closely related to the spleen, kidneys and other internal organs. Children's internal organs are delicate, the qi and blood are not filled, and the internal organs are not dense. Two injuries affect the spleen's transport and chemical functions. When clearing and moisturizing the lungs, promoting the spleen and dampness. [0003] Chinese medicine believes that children’s internal organs are delicate, the lung guard is not firm, the physique is not dense, the cold and warmth cannot be adjusted by themse...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/899A61P11/14A61P11/10A61K33/00A61K33/06A61K35/64
Inventor 潘勤闫晓楠江永萍宋立平李妍
Owner 津药达仁堂集团股份有限公司达仁堂制药厂
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