Application of bisbenzylisoquinoline compound or pharmaceutically acceptable salt thereof in preparing medicine or healthcare product for improving sleep

A bisbenzylisoquinoline, sleep-improving technology, applied to medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc., can solve problems such as no research reports

Inactive Publication Date: 2012-07-11
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The pharmacological effects and clinical application of tetrandrine and fangchinoline modified compounds in improving sleep have not been reported so far

Method used

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  • Application of bisbenzylisoquinoline compound or pharmaceutically acceptable salt thereof in preparing medicine or healthcare product for improving sleep
  • Application of bisbenzylisoquinoline compound or pharmaceutically acceptable salt thereof in preparing medicine or healthcare product for improving sleep
  • Application of bisbenzylisoquinoline compound or pharmaceutically acceptable salt thereof in preparing medicine or healthcare product for improving sleep

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] Experiment 1. Effects of bisbenzylisoquinoline (BBI) derivatives represented by formula (I) on total sleep time and sleep phase (REM and NREM sleep) of mice after administration for 1, 3, and 7 days respectively.

[0013] The mice were taken, and electroencephalogram (EEG) and electromyography (EMG) electrodes were installed after anesthesia. One week after the operation, they were divided into random groups. The control group was given vehicle by intragastric administration, and the other groups were administered intragastrically with BBI derivatives at doses of 1, 15, and 30 mg / kg for 1 day, 3 days and 7 days respectively. Immediately after the last administration, the EEG and EMG were recorded for 8 hours. The EEG and EMG were analyzed with SleepSign for Animal 2.0 software, and the results are shown in Table 1. The experimental results showed that intragastric administration of the derivatives for 1 day (Table 1), 3 days (Table 2), and 7 days (Table 3) could dose-d...

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PUM

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Abstract

The invention discloses a new use of bisbenzylisoquinoline compound shown in formula (I) or pharmaceutically acceptable salt thereof except for tetrandrine and fangchinoline. The use is application of the bisbenzylisoquinoline compound shown in formula (I) or pharmaceutically acceptable salt thereof in preparing a medicine or healthcare product for treating insomnia and improving sleep. The bisbenzylisoquinoline compound shown in formula (I) or pharmaceutically acceptable salt thereof can be used as an effective component and made into any dosage form. The result of animal experiment indicates that: the bisbenzylisoquinoline compound shown in formula (I) or pharmaceutically acceptable salt thereof can obviously prolong the total sleep time of normal rats and mouse, including REM (rapid eye movement) sleep time and NREM (non-rapid eye movement) sleep time. The application disclosed by the invention is suitable for various types of insomnia or sleep disorders.

Description

technical field [0001] The present invention relates to the preparation of bisbenzylisoquinoline compounds or pharmaceutically acceptable salts thereof with general structural formula as shown in the figure except tetrandrine and fangchinoline for the treatment of insomnia Diseases and sleep-improving medicines or health products. Background technique [0002] The structural formula of bisbenzylisoquinolines, as shown in formula (I): [0003] [0004] Among them, R 1 Is hydrogen, or a straight chain or branched chain alkyl group containing 1-10 carbon atoms; R 2 , R 3 , R 4 and R 5 Respectively one of the following groups: hydrogen, substituted acyl, linear or branched alkyl, and the alkyl can be interrupted by heteroatoms selected from O, N, S; R 2 , R 3 , R 4 and R 5 It can also be O or S together. x 1 , X 2 , X 3 and x 4 may be the same or different, and each independently is a halogen atom, nitro, hydroxyl, or a linear or branched alkyl or alkoxy or acyl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61P25/20A61P25/18A61P25/22A61P25/24A61P25/28
Inventor 张永鹤张娟
Owner PEKING UNIV
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