Anti-lung-cancer traditional Chinese medicine composite, preparation method of composite, and application of composite in preparation of anti-lung-cancer medicament

Abstract

The invention discloses an anti-lung-cancer traditional Chinese medicine composite, a preparation method of the composite, and an application of the composite in preparation of an anti-lung-cancer medicament. The composite comprises the following active pharmaceutical ingredients in parts by weight: 5 to 40 parts of ganoderma lucidum, 5 to 40 parts of semen coicis and 1 to 10 parts of lily; and as optimization, the composite comprises 20 parts of ganoderma lucidum, 20 parts of semen coicis and 3 parts of lily. The composite consists of six active ingredients including total triterpenoid of the ganoderma lucidum, coix seed oil, total alkaloids of the lily, ganoderma lucidum polysaccharides, semen coicis polysaccharides and lily polysaccharides. The composite disclosed by the invention has an obvious inhibition effect on the growth of Lewis tumors, the antitumor activity of the composite is superior to that of a single component after compatibility administration, and the tumor inhibition rate of the composite can reach 55.13%. Therefore, the active ingredients in the composite are extracted and separated to the greatest extent by virtue of a modern extraction and separation method, and the collaborative antitumor effect of the composite can better come into play by virtue of compatibility combination.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an anti-lung cancer traditional Chinese medicine composition, a preparation method of the anti-lung cancer traditional Chinese medicine composition, and an application of the traditional Chinese medicine composition in preparing anti-lung cancer medicines. Background technique [0002] At present, lung cancer has become a major killer threatening human health. According to domestic and foreign literature reports, the number of new cases of lung cancer in the world is as high as 205,020, accounting for about 14% of the new cases of various tumors in the world, and it has the characteristics of high incidence and high mortality. Under the influence of various factors such as environmental pollution, smoking, ionizing radiation, occupational exposure, and viral infection, the incidence and mortality of lung cancer have been on the rise, increasing at a rate of ...

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Problems solved by technology

[0004] After searching, there are a variety of traditional Chinese medicine compositions for treating cancer in the existing patents, such as "a medicine and food composition suitable for cancer patients and its preparation method" (patent number: 200910266137.0), "a cancer treatment Traditional Chinese medicine” (Patent No.: 200710166579.9); “A Chinese herbal composition for treating liver, stomach, lung and blood cancer and its preparation method” (Patent No.: 201110125724.5); “A Chinese herbal composition for treating cancer and its preparation method "(Patent No.: 201110165923.9); "A Traditional Chinese Medicine Composition and Its Application for Treating Malignant Tumors" (Patent No.: 201110145442.1), "Anti-cancer Traditional Chinese Medicine Composition and Its Application" (201110056786.5), etc. The drugs used in these compositions There are many types, and they are mostly taken in decoction, or the preparation process is relatively simple. After extracting the extract, it is directly made into an oral preparation. The dosage of the preparation is large. Although it has a certain therapeutic effect in clinical practice, the extraction rate of active ingredients Lower, the preparation is thicker, which is not conducive to the quality control of the preparation

[0005] Patents have reported the anti-tumor preparations of Ganoderma lucidum and coix seed (200910031997.6 discloses a self-microemulsified nano-emulsified composition of Ganoderma lucidum triterpenoid extract with anti-tumor activity and its preparation method; 201110097796.3 discloses a compound Ganoderma lucidum spore soft Capsules and their preparation methods; 101010237432.6 discloses a coix seed anti-cancer traditional Chinese medicine and its preparation method), these anti-tumor preparations only use the single active components of ganoderma lucidum total triterpenes and coix seed oil, and some of them play an auxiliary role According to literature reports [Lin Zhibin, Wang Pengyun. Pharmacological research on Ganoderma lucidum spores and their active ingredients[J]. Peking University Journal (Medical Edition), 2006,38(5):541-547; Zhang Yumei, Yang Junshan, Zhao Yangjing, et al. Research progress on the chemical constituents and pharmacological activities of coix coix [J]. Chinese Journal of Pharmaceutical Sciences, 2002,37(1):8-11], Ganoderma lucidum polysaccharide and coix seed polysaccharide also have anti-tumor and immune regulation effects, so The above-mentioned preparations cannot reflect the characteristics of multi-component and multi-target overall treatment of traditional Chinese medicine

In addition, 201010187617.0 discloses the preparation of an anticancer drug composition and a traditional Chinese medicine composition. Although this invention pays attention to the preparation of the traditional Chinese medicine composition (the medicinal material itself, the decoction of the medicinal material, the concentrated extract of the decoction or the decoction Concentrated dry powder) and polysaccharide components are used in combination, but the pharmaceutical composition contains many types of medicinal materials, and the polysaccharide components are not derived from the medicinal materials in the composition, the composition is complex, and it is difficult to carry out quality control

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