Anti-lung-cancer traditional Chinese medicine composite, preparation method of composite, and application of composite in preparation of anti-lung-cancer medicament

A composition and anti-lung cancer technology, which can be used in drug combinations, anti-tumor drugs, pharmaceutical formulations, etc., can solve problems such as the inability to reflect the multi-component and multi-target holistic treatment of traditional Chinese medicine, the large dosage of preparations, and the complex components.

Active Publication Date: 2012-08-22
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Abstract
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Problems solved by technology

[0004] After searching, there are a variety of traditional Chinese medicine compositions for treating cancer in the existing patents, such as "a medicine and food composition suitable for cancer patients and its preparation method" (patent number: 200910266137.0), "a cancer treatment Traditional Chinese medicine” (Patent No.: 200710166579.9); “A Chinese herbal composition for treating liver, stomach, lung and blood cancer and its preparation method” (Patent No.: 201110125724.5); “A Chinese herbal composition for treating cancer and its preparation method "(Patent No.: 201110165923.9); "A Traditional Chinese Medicine Composition and Its Application for Treating Malignant Tumors" (Patent No.: 201110145442.1), "Anti-cancer Traditional Chinese Medicine Composition and Its Application" (201110056786.5), etc. The drugs used in these compositions There are many types, and they are mostly taken in decoction, or the preparation process is relatively simple. After extracting the extract, it is directly made into an oral preparation. The dosage of the preparation is large. Although it has a certain therapeutic effect in clinical practice, the extraction rate of active ingredients Lower, the preparation is thicker, which is not conducive to the quality control of the preparation
[0005] Patents have reported the anti-tumor preparations of Ganoderma lucidum and coix seed (200910031997.6 discloses a self-microemulsified nano-emulsified composition of Ganoderma lucidum triterpenoid extract with anti-tumor activity and its preparation method; 201110097796.3 discloses a compound Ganoderma lucidum spore soft Capsules and their preparation methods; 10...

Method used

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  • Anti-lung-cancer traditional Chinese medicine composite, preparation method of composite, and application of composite in preparation of anti-lung-cancer medicament
  • Anti-lung-cancer traditional Chinese medicine composite, preparation method of composite, and application of composite in preparation of anti-lung-cancer medicament
  • Anti-lung-cancer traditional Chinese medicine composite, preparation method of composite, and application of composite in preparation of anti-lung-cancer medicament

Examples

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Embodiment 1

[0119] Example 1, anti-lung cancer traditional Chinese medicine composition, the composition of raw materials by weight is as follows: Step (1) 20 parts of Ganoderma lucidum, 20 parts of coix seed, and 3 parts of lily. Ganoderma lucidum fruiting bodies were crushed and sieved with supercritical CO 2 The total triterpenoid components of Ganoderma lucidum were extracted by extraction method, the extraction pressure was 30 MPa, the extraction temperature was 45 ℃; the extraction time was 1.5 h, and the amount of entrainer (95% ethanol) was 3 mL·g -1 herbal medicine. Step ⑵: Add 10 times the amount of water to decoct the residue of ganoderma lucidum coarse powder, and decoct twice for 1 hour each time; concentrate the filtrate, and settle the concentrate until the ethanol concentration (volume percentage) is 80%; collect the precipitate, The precipitate is redissolved with 6 times the amount of water; insoluble impurities such as protein are removed, concentrated and dried, and f...

Embodiment 2

[0121] Example 2 is basically the same as Example 1, but with the following changes, the composition of the bulk drug in parts by weight is as follows: 5 parts of Ganoderma lucidum, 5 parts of coix seed, and 1 part of lily. At the same time, the extraction conditions described in step (1) are: pressure 25 MPa, extraction temperature 43 °C; extraction time 1 h, entrainer (95% ethanol) dosage 1 mL g -1 Crude drug; decocting with water as described in step (2) is to add 8 times the amount of water to decoct, and the number of decoctions is 1 time, each time 2 h; the condition for the alcohol precipitation of the concentrated solution is that the concentrated solution is alcohol-precipitated to the concentration of ethanol (volume percentage) is 75%; the precipitate is redissolved with 4 times the amount of water; the extraction conditions described in step (3) are: the extraction pressure is 20MPa, the extraction temperature is 35 °C, the extraction time is 2 h, and the entrainer ...

Embodiment 3

[0122] Example 3 is basically the same as Example 1, but with the following changes, the composition of the bulk drug in parts by weight is as follows: 40 parts of Ganoderma lucidum, 40 parts of coix seed, and 10 parts of lily. At the same time, the extraction conditions described in step (1) are: pressure 35 MPa, extraction temperature 48 °C; extraction time 2 h, entrainer (95% ethanol) dosage 2 mL g -1 Crude drug; decocting with water as described in step (2) is to add 13 times the amount of water to decoct, and the number of decoctions is 2 times, each time for 2 hours; the condition for the alcohol precipitation of the concentrated solution is that the concentrated solution is alcohol-precipitated to the concentration of ethanol (volume percentage) is 85%; the precipitate is redissolved with 10 times the amount of water; the extraction conditions described in step (3) are: the extraction pressure is 25MPa, the extraction temperature is 40°C, the extraction time is 3 h, and ...

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Abstract

The invention discloses an anti-lung-cancer traditional Chinese medicine composite, a preparation method of the composite, and an application of the composite in preparation of an anti-lung-cancer medicament. The composite comprises the following active pharmaceutical ingredients in parts by weight: 5 to 40 parts of ganoderma lucidum, 5 to 40 parts of semen coicis and 1 to 10 parts of lily; and as optimization, the composite comprises 20 parts of ganoderma lucidum, 20 parts of semen coicis and 3 parts of lily. The composite consists of six active ingredients including total triterpenoid of the ganoderma lucidum, coix seed oil, total alkaloids of the lily, ganoderma lucidum polysaccharides, semen coicis polysaccharides and lily polysaccharides. The composite disclosed by the invention has an obvious inhibition effect on the growth of Lewis tumors, the antitumor activity of the composite is superior to that of a single component after compatibility administration, and the tumor inhibition rate of the composite can reach 55.13%. Therefore, the active ingredients in the composite are extracted and separated to the greatest extent by virtue of a modern extraction and separation method, and the collaborative antitumor effect of the composite can better come into play by virtue of compatibility combination.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to an anti-lung cancer traditional Chinese medicine composition, a preparation method of the anti-lung cancer traditional Chinese medicine composition, and an application of the traditional Chinese medicine composition in preparing anti-lung cancer medicines. Background technique [0002] At present, lung cancer has become a major killer threatening human health. According to domestic and foreign literature reports, the number of new cases of lung cancer in the world is as high as 205,020, accounting for about 14% of the new cases of various tumors in the world, and it has the characteristics of high incidence and high mortality. Under the influence of various factors such as environmental pollution, smoking, ionizing radiation, occupational exposure, and viral infection, the incidence and mortality of lung cancer have been on the rise, increasing at a rate of ...

Claims

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Application Information

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IPC IPC(8): A61K36/8994A61P11/00A61P35/00
Inventor 陈彦杜萌曹伟贺俊杰
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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