Diamino polyethylene glycol modified paramagnetic metal complex magnetic resonance imaging contrast agent

A paramagnetic metal and magnetic resonance imaging technology, which is applied in X-ray contrast agent preparation, echo/ultrasound imaging agent, preparations for in vivo tests, etc., can solve the problem of low relaxation rate of contrast agent, large dosage and high toxicity etc. to achieve good water solubility, low immunogenicity and low toxicity
CN102727911BActive Publication Date: 2013-07-24CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
Publication Date
2013-07-24

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Abstract

The invention provides a diamino polyethylene glycol modified paramagnetic metal complex magnetic resonance imaging contrast agent, and aims at solving the problems of low relaxation rate, high toxicity and large dosage of a contrast agent in the prior art. The contrast agent is prepared by the following steps: reacting 1,4,7,10-tetrazacyclododecane-1,4,7,10-tetraacetic acid compound with diaminopolyethylene glycol with different molecular weights; preparing a macromolecular ligand through an amidation reaction; and forming a paramagnetic metal complex with paramagnetic metal elements Sc, Ti, V, Mn, Cu, Mo, Ru, Fe or positive trivalent or divalent ion of lanthanide rare-earth elements. The contrast agent has the advantages of high stability, water solubility, relaxation rate and small dosage.
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Description

technical field

[0001] The invention relates to a contrast agent for magnetic resonance imaging, more specifically, to a contrast agent for magnetic resonance imaging of a paramagnetic metal complex modified by diaminopolyethylene glycol. Background technique

[0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is a medical diagnostic technology with high safety factor and high resolution, which can perform tomographic scanning from all directions. Today, this technology has made great contributions in clinical medicine. In order to obtain accurate diagnosis of some more complex diseases, about 30-40% of MRI examinations require the use of contrast agents. Magnetic resonance contrast agents used in clinical medical examinations can improve imaging contrast, imaging clarity, soft tissue resolution, and tissue sensitivity.

[0003] At present, the magnetic resonance contrast agents used in clinical medicine, such as dotalin and magenvist, have small molecula...

Claims

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