Allergy inhibitor

A substance and allergy technology, applied in allergic diseases, food science, drug combination, etc., can solve problems such as unclear details

Active Publication Date: 2012-12-05
EUGLENA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In recent years, it has been reported that β-1,3-glucan has an immunoregulatory function, and shows the effect of im

Method used

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Embodiment Construction

[0059] Hereinafter, one embodiment of the present invention will be described based on the drawings.

[0060]It should be noted that the configuration described below does not limit the present invention, but can be variously modified within the scope of the present invention.

[0061] The present embodiment relates to amorphous paramylon in which crystalline paramylon is amorphized and has a further improved useful effect than crystalline paramylon.

[0062] figure 1 It is a process chart showing the manufacturing process of amorphous paramylon, figure 2 It is a scan diagram showing the full scan result of the diffraction peak position confirmation of amorphous paramylon, image 3 is a scanning image showing detailed scanning results for the measurement of the diffraction intensity of amorphous paramylon, Figure 4 is the experimental protocol, Figure 5 is a graph representing the result of the dermatitis score, Figure 6 It is a photograph taken of the condition of th...

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Abstract

The present invention provides an allergy inhibitor using the efficacy of amorphous paramylon which is a substance obtained by changing the crystalline structure of paramylon. The present invention relates to a substance for inhibiting allergic diseases. Amorphous paramylon of the present invention is an allergy inhibitor comprising amorphous paramylon which is obtained by amorphosizing crystalline paramylon derived from Euglena, and has a relative crystallinity of 20% or lower to the crystallinity of crystalline paramylon, determined by an X-ray diffractometry. This allergy inhibitor enables efficacious inhibition of allergic diseases such as atopic dermatitis, pollinosis, and the like.

Description

technical field [0001] The present invention relates to an allergy suppressing substance utilizing the effect of amorphous paramylon, which is a substance obtained by changing the crystal structure of paramylon. Background technique [0002] Atopic dermatitis, one of the allergic diseases, is considered to exhibit dermatitis symptoms accompanied by itching by acquiring an allergic reaction to environmental antigens (house dust, pollen, mold, etc.) and causing an excessive reaction to environmental antigens . [0003] In order to establish sensitization by the above-mentioned allergens, antigen phagocytosis and presentation of antigen information by antigen-presenting cells and antigen recognition by Th2-type CD4+ T cells are required. [0004] There are cases where Th2-type CD4+T cells infiltrate into skin lesions, produce cytokines, and cause inflammation (type 4 hypersensitivity); and cause B Inflammation caused by degranulation of mast cells in peripheral tissues after ...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/716A61P11/02A61P17/02A61P37/08
CPCC08B37/0024A61K31/716A61P11/02A61P17/02A61P37/08A23L33/10A23V2002/00A23V2200/318
Inventor 铃木健吾
Owner EUGLENA
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