Composition for prevention or treatment of oral disease comprising Epimedium Herb extract

Abstract

The invention relates to a composition for prevention or treatment of an oral disease comprising an epimedium herb extract, and particularly to a medical external composition which has a preventing orimmprovement effect on dental caries, parodontopathy, toothache, hemodia and ozostomia. The composition of the invention has excellent antibacterial activity to bacteria which cause dental caries andparodontopathy, and furthermore suppresses the PGE2 as a pain and inflammation marker according to the concentration. Furthermore the compositions has an excellent gingivitis forming effect, a epimedium suppressing effect and an ozostomia preventing effect, thereby realizing high application value as a medical external composition for preventing or improving more than one oral disease selected from a set which is composed of dental caries, parodontopathy, toothache, hemodia and ozostomia. Furthermore the composition of the invention can be used as a medical composition and a food composition.

Description

technical field [0001] The present invention relates to a composition for the prevention or treatment of oral diseases comprising Epimedium Herb extract, and more particularly, to medicines having preventive or ameliorating effects on dental caries, periodontal disease, toothache, tooth hypersensitivity, and halitosis Foreign products ( Quasi-drug) composition. Furthermore, the present invention relates to a pharmaceutical composition, a food composition, and an oral composition comprising the herbal extract of Epimedium. Background technique [0002] Healthy teeth are one of the five blessings and an important factor in determining the quality of life. Among oral diseases, dental caries (dental cavities, tooth decay) and periodontal disease (periodontal disease, wind tooth) are diseases with a high incidence rate in the world, and are known to cause diseases such as pain, masticatory dysfunction, periodontal tissue destruction, bad breath and tooth hypersensitivity. and...

AI Technical Summary

Problems solved by technology

[0005] However, since antibiotics have systemic side effects on our body, and may cause the emergence of resistant bacteria in the oral cavity and secondary infection (superinfection), it has the disadvantage of being difficult to use for a long time and can only be used as a therapeutic agent.

In addition, as an antibacterial preparation used as an oral cavity cleaning agent, there are Sangquinarine, Listerine, Peroxide, Chlorhexidine, etc. Sanguinarine has the ability to inhibit bacteria in the oral cavity. The role of listerine is not yet clear, the effect on periodontal disease is even less clear and the price is high. The main component of Listerine is ethanol. Although it has a certain antibacterial effect, its disadvantage is that it only shows a temporary effect in the oral cavity. effects, which may cause deleterious effects on tissues in prolonged use

In addition, recently, peroxides added for whitening effects are toxic to bacteria, but they also show toxicity to human tissues, so not only is there a safety problem, but also occasionally bacteria resistant to peroxides appear in bacteria.

In addition, chlorhexidine is currently the most excellent agent among agents for inhibiting plaque formation and preventing and treating periodontal diseases, however, chlorhexidine not only causes irritation to tissues, coloring and denaturation of tissues, In particular, it has side effects such as strong irritating taste and heavy taste, and it can also cause secondary infection and is carcinogenic, so it has the disadvantages that it cannot be used for a long time for the purpose of treatment or especially prevention, such as limited use for pregnant women.

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