Wide-frequency-band optical-acoustic and fluorescent double-imaging device without energy converter and detection method thereof

A fluorescent signal detection and transducer technology, applied in measuring devices, fluorescence/phosphorescence, instruments, etc., can solve problems such as narrow frequency bands, achieve organic integration, get rid of the limitation of photoacoustic signal detection position, and get rid of bandwidth limitation defects Effect

Active Publication Date: 2014-12-31
SOUTH CHINA NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Traditional photoacoustic signal detection tools are generally ultrasonic transducers, and photoacoustic signals have a wide frequency band, but traditional ultrasonic transducers are limited by materials, and generally have narrow frequency bands

Method used

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  • Wide-frequency-band optical-acoustic and fluorescent double-imaging device without energy converter and detection method thereof
  • Wide-frequency-band optical-acoustic and fluorescent double-imaging device without energy converter and detection method thereof
  • Wide-frequency-band optical-acoustic and fluorescent double-imaging device without energy converter and detection method thereof

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Experimental program
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Effect test

Embodiment 1

[0041] like figure 1 As shown, a broadband transducerless photoacoustic and fluorescence dual imaging device, including photoacoustic / fluorescence excitation light source and photoacoustic signal detection light source assembly, photoacoustic signal detection assembly, fluorescence signal detection assembly and photoacoustic / fluorescence signal acquisition / Processing components; photoacoustic / fluorescence excitation light source and photoacoustic signal detection light source components are respectively connected with photoacoustic signal detection component, photoacoustic / fluorescence signal acquisition / processing component, photoacoustic signal detection component is respectively connected with fluorescence signal detection component, photoacoustic / fluorescence signal detection component Connection of signal acquisition / processing components, connection of fluorescence signal detection components and photoacoustic / fluorescence signal acquisition / processing components;

[00...

Embodiment 2

[0057] The detection method using the broadband transducerless photoacoustic and fluorescent dual imaging device of embodiment 1 comprises the following steps:

[0058] (1) Drop the FITC solution of fluorescein isothiocyanate with a pH value of 5.5 on the slide, and place the slide on the sample stage;

[0059] (2) Place the photoacoustic signal detection component and the fluorescent signal detection component directly above the sample surface, and make the photoacoustic signal detection component and the fluorescent signal detection component in the vertical direction;

[0060] (3) The photoacoustic excitation light and the photoacoustic signal detection light are combined into a beam of light through the dichroic mirror A, and then sequentially pass through the two-dimensional scanning galvanometer, the polarization beam splitter and the flat field objective lens to irradiate the sample surface, so that the photoacoustic signal detection The light is focused on the surface ...

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Abstract

The invention discloses a wide-frequency-band optical-acoustic and fluorescent double-imaging device without an energy converter and a detection method thereof. The device comprises an optical-acoustic / fluorescent stimulating light source, an optical-acoustic signal detection light source assembly, an optical-acoustic signal detection assembly, a fluorescent signal detection assembly and an optical-acoustic / fluorescent signal collecting / processing assembly, wherein the optical-acoustic / fluorescent stimulating light source and the optical-acoustic signal detection light source assembly are respectively connected with the optical-acoustic signal detection assembly and the optical-acoustic / fluorescent signal collecting / processing assembly; the optical-acoustic detection assembly is respectively connected with the fluorescent signal detection assembly and the optical-acoustic / fluorescent signal collecting / processing assembly; and the fluorescent signal detection assembly is connected with the optical-acoustic / fluorescent signal collecting / processing assembly. According to the wide-frequency-band optical-acoustic and fluorescent double-imaging device without the energy converter and the detection method thereof, an optical-acoustic signal is produced by using pulse laser to irradiate a biological sample; continuous laser with a narrower line width is focused on the surface of a sample and the aim of detecting an optical-acoustic signal is achieved by detecting the vibration speed of the surface of the sample; and a bandwidth limitation detect of the energy converter is eliminated and the organic combination of optical-acoustic and fluorescent double-imaging is realized.

Description

technical field [0001] The invention belongs to the technical field of photoacoustic imaging, and in particular relates to a broadband transducer-less photoacoustic and fluorescent dual imaging device and a detection method thereof. Background technique [0002] When a certain absorber is irradiated with light, the absorber absorbs the light energy and produces a temperature rise, and the temperature rise and fall causes the volume of the absorber to expand and shrink, and ultrasonic waves are generated. This phenomenon is called the photoacoustic effect. The photoacoustic effect has attracted people's attention since it was discovered in the 19th century, and it has been applied in various fields to varying degrees. As a new imaging technology, photoacoustic imaging has been applied in more and more fields. This imaging technology uses short-pulse laser as the excitation source, and the ultrasonic signal excited by it as the information carrier. By reconstructing the image...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/17G01N21/64
Inventor 邢达陈重江杨思华
Owner SOUTH CHINA NORMAL UNIVERSITY
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