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Composition of active ingredient of traditional chinese medicine and use thereof

A technology of active ingredients and compositions, which is applied in the field of active ingredients and compositions of traditional Chinese medicine, and can solve problems such as lack of pharmaceutical preparations

Active Publication Date: 2015-07-15
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The inventor has noticed that there is still a lack of pharmaceutical preparations that can be used to replenish qi and detoxify to treat brain and nerve damage diseases

Method used

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  • Composition of active ingredient of traditional chinese medicine and use thereof
  • Composition of active ingredient of traditional chinese medicine and use thereof
  • Composition of active ingredient of traditional chinese medicine and use thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0035] (1) The preparation of ginsenoside monomer Rf1 is prepared with reference to the patented method (the medical use of ginsenoside F1, application number 200610008477.X);

[0036] (II) The preparation of ginsenoside monomer Re is carried out with reference to the patented method (new medical application and preparation method of ginsenoside Re, application number 2004110021133.6);

[0037] (III) The preparation of ginsenoside monomer Rg1 refers to the patented method for preparation (the use of ginsenoside Rg1, application number 200810227643.4);

[0038] (IV) The preparation of ginsenoside monomer Rb1 refers to the patented method (a preparation method of ginsenoside Rb1, application number 200710178212.9);

[0039] (V) The preparation of ginsenoside monomer Rh (Rh1 and Rh2) is prepared by referring to the patent method (ginsenoside Rh extract and preparation method, application number 200810043537.0);

[0040] (VI) The preparation of ginsenoside monomer Rd was prepared...

Embodiment 1

[0048] Example 1: The composition of the present invention has a protective effect on animals with acute focal cerebral ischemia.

[0049] Animal model establishment of acute focal cerebral ischemia (middle cerebral artery embolization (MCAO) operation)

[0050] Male SD rats with a body weight of 250-270g were used, referring to the rats established by Zea Longa et al. Methods of occlusion of the middle cerebral artery with thread embolization. 400 mg / kg of 10% chloral hydrate solution was injected intraperitoneally to anesthetize the animal. Rats were fixed in the supine position, the skin was incised in the middle of the neck, and all layers of tissue were bluntly separated to expose the right common carotid artery (CCA). After the bifurcation of the internal carotid artery (ICA) and external carotid artery (ECA), it was separated carefully to avoid damage to the vagus nerve and trachea, and the line was placed for use. The ipsilateral external carotid artery was separate...

Embodiment 2

[0077]Example 2 Research experiment on the protective effect of the composition of the present invention on the reperfusion after ischemia in animals with focal cerebral ischemia

[0078] Preparation of ischemia-reperfusion model after middle cerebral artery occlusion (MCAO)

[0079] Male SD rats with a body weight of 250-270g were used, referring to the rats established by Zea Longa et al. Appropriate improvements were made to the method of occlusion of the middle cerebral artery with thread embolization.

[0080] 400 mg / kg of 10% chloral hydrate solution was injected intraperitoneally to anesthetize the animal. Rats were fixed in the supine position, the skin was incised in the middle of the neck, and all layers of tissue were bluntly separated to expose the right common carotid artery (CCA). After the bifurcation of the internal carotid artery (ICA) and external carotid artery (ECA), it was separated carefully to avoid damage to the vagus nerve and trachea, and the line w...

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Abstract

Disclosed is a composition of an active ingredient of traditional Chinese medicine, comprising geniposide or jasminoidin, berberine, total saponins of panax ginseng or a composition of ginsenoside monomer. Also disclosed is the use of the pharmaceutical composition in preparing drugs for treating or preventing brain and nerve damage, neurodegenerative encephalopathy, bacterial or viral encephalitis, or depression.

Description

technical field [0001] The invention relates to a traditional Chinese medicine active ingredient composition, which comprises geniposide or geniposide, berberine, total ginsenosides or ginsenoside monomers or a ginsenoside monomer composition. The present invention also relates to the use of the composition in the preparation of medicines for treating or preventing brain and nerve damage, neurodegenerative encephalopathy, bacterial or viral encephalitis, or depression. Background technique [0002] TCM theory attaches great importance to the overall concept and syndrome differentiation and treatment. Traditional Chinese medicine theory believes that qi deficiency and blood stasis are the important pathogenesis of stroke, qi deficiency is the root of the disease, blood stasis is the basic pathogenesis of the disease, and is the core of the disease's occurrence and development. The basic method of treating this disease. Qi deficiency and blood stasis are only seen in the sequ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/704A61K31/4375A61P9/10A61P25/16A61P25/24A61P25/28A61P25/00
CPCA61K31/4375A61K31/4741A61P9/10A61P25/00A61P25/16A61P25/24A61P25/28
Inventor 杨洪军李韶菁王永炎黄璐琦付梅红
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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