Composition containing Chinese medicine active ingredients and application thereof

A technology of active ingredients and compositions, applied in the field of active ingredient compositions of traditional Chinese medicine, can solve problems such as lack of pharmaceutical preparations

Inactive Publication Date: 2013-01-09
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The inventor has noticed that there is still a lack of pharmaceutical preparations that can be used to replenish qi and detoxify to treat brain and nerve damage diseases

Method used

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  • Composition containing Chinese medicine active ingredients and application thereof
  • Composition containing Chinese medicine active ingredients and application thereof
  • Composition containing Chinese medicine active ingredients and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0035] (1) The preparation of ginsenoside monomer Rf1 is prepared with reference to the patented method (the medical use of ginsenoside F1, application number 200610008477.X);

[0036] (II) The preparation of ginsenoside monomer Re is carried out with reference to the patented method (new medical application and preparation method of ginsenoside Re, application number 2004110021133.6);

[0037] (III) The preparation of ginsenoside monomer Rg1 refers to the patented method for preparation (the use of ginsenoside Rg1, application number 200810227643.4);

[0038] (IV) The preparation of ginsenoside monomer Rb1 refers to the patented method (a preparation method of ginsenoside Rb1, application number 200710178212.9);

[0039] (V) The preparation of ginsenoside monomer Rh (Rh1 and Rh2) is prepared by referring to the patent method (ginsenoside Rh extract and preparation method, application number 200810043537.0);

[0040] (VI) The preparation of ginsenoside monomer Rd was prepared...

Embodiment 1

[0048] Example 1: The composition of the present invention has a protective effect on animals with acute focal cerebral ischemia.

[0049] Animal Model Establishment of Acute Focal Cerebral Ischemia

[0050] Male SD rats with a body weight of 250-270 g were used, referring to the large scale established by Zea Longa et al. (Longa EZ, Weinstein PR, Carlson S, Cummins R. A method for occluding the middle cerebral artery with a suture. 400 mg / kg of 10% chloral hydrate solution was injected intraperitoneally to anesthetize the animal. Rats were fixed in the supine position, the skin was incised in the middle of the neck, and all layers of tissue were bluntly separated to expose the right common carotid artery (CCA). After the bifurcation of the internal carotid artery (ICA) and external carotid artery (ECA), it was separated carefully to avoid damage to the vagus nerve and trachea, and the line was placed for use. The ipsilateral external carotid artery was separated and ligate...

Embodiment 2

[0064] Embodiment 2 Composition of the present invention is to senile dementia (AD) animal protective effect research experiment

[0065] β-amyloid (Aβ 1-40 ) incubation

[0066] Aβ with sterile saline 1-40 Dilute to 2ug / ul, incubate at 37°C for 1 week to make it into condensed Aβ 1-40 .

[0067] Aβ 1-40 Establishment of rat dementia model

[0068] Take 250-270g healthy male AD rats and fix them on the rat stereotaxic apparatus after anesthesia, routine skin preparation and disinfection, incise the skin, expose the bregma, and use a micro-injection syringe to the left hippocampus of the rats (with Bregma point as 0 point) , AP-3.0mm, ML2.0mm, DV-2.9mm) slowly inject condensed Aβ 1-40 5 μl, retain the needle for 5 minutes to fully diffuse Aβ, then withdraw the needle slowly, and suture the incision. In the sham operation group, only preoperative anesthesia was performed, the skin was incised to expose the bregma, and Aβ was not injected 1-40 .

[0069] Experimental gro...

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Abstract

The invention relates to composition containing Chinese medicine active ingredients and an application thereof. The composition comprises geniposide or gardenoside, berberine, total saponins of panax ginseng or ginsenoside monomer or ginsenoside monomer composition. The invention further relates to the application of the composition in preparing medicines for treating or preventing brain and nerve injuries, neurodegenerative diseases, bacterial or viral encephalitis, or depression.

Description

technical field [0001] The invention relates to a traditional Chinese medicine active ingredient composition, which comprises geniposide or geniposide, berberine, total ginsenosides or ginsenoside monomers or a ginsenoside monomer composition. The present invention also relates to the use of the composition in the preparation of medicines for treating or preventing brain and nerve damage, neurodegenerative encephalopathy, bacterial or viral encephalitis, or depression. Background technique [0002] TCM theory attaches great importance to the overall concept and syndrome differentiation and treatment. Traditional Chinese medicine theory believes that qi deficiency and blood stasis are the important pathogenesis of stroke, qi deficiency is the root of the disease, blood stasis is the basic pathogenesis of the disease, and is the core of the disease's occurrence and development. The basic method of treating this disease. Qi deficiency and blood stasis are only seen in the sequ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/7048A61P25/00A61P25/28A61P9/10A61P25/24A61P25/16A61K31/704A61K31/4375
CPCA61K31/704A61K31/4375A61K31/7048A61K31/4741A61K36/258A61P9/10A61P25/00A61P25/16A61P25/24A61P25/28
Inventor 杨洪军李韶菁王永炎黄璐琦付梅红
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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