Method for constructing animal model of hyperuricemia induced renal interstitial fibrosis
A technology for renal interstitial fibrosis and hyperuricemia, which is applied in the directions of active ingredients of heterocyclic compounds, pharmaceutical formulations, plant raw materials, etc., can solve problems such as disease deterioration, treatment delay, lack of systematic understanding of the disease, and standardized diagnosis and treatment methods.
Inactive Publication Date: 2013-08-28
李长贵
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Problems solved by technology
[0004] Unfortunately, the clinical misdiagnosis rate of hyperuricemia nephropathy is as high as 80%, leading to delays in treatment, deterioration of the condition, and eventually the development of uremia. The consequences are heart-wrenching.
However, there is currently a lack of systematic understanding and standardized diagnosis and treatment of this disease. Therefore, it is of great significance to establish an animal model of renal interstitial fibrosis caused by hyperuricemia and carry out research on related diseases.
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Embodiment 1
[0080] Embodiment 1, the establishment of the Wistar rat animal model of hyperuricemia-induced renal interstitial fibrosis
[0081] 1. Experimental grouping with diet plan
[0082] After adapting to feeding for one week, 60 male Wistar rats (6 weeks old) were randomly divided into 2 groups according to body weight, namely normal group and high uric acid group, 30 rats in each group.
[0083] Rats in the high uric acid group were all fed with yeast feed containing 10% yeast powder, and fed with adenine aqueous solution with a concentration of 20g / L according to the dosage of 100mg adenine / (kg body weight·d); rats in the normal group were fed with Rats were fed with ordinary pellets and given the same volume of distilled water for gavage.
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Abstract
The invention discloses a method for constructing an animal model of hyperuricemia induced renal interstitial fibrosis. The method comprises the following steps of: feeding an objective animal by using a feed containing 10 percent by mass of yeast powder; performing intragastric administration on the objective animal by using an aqueous solution of adenine according to the following consumption: 100mg adenine / day / kg (weight), till the blood uric acid level of the objective animal rises; and after renal interstitial fibrosis appears at the kidney, obtaining the animal model of the hyperuricemia induced renal interstitial fibrosis. By adopting the method, the animal model of the hyperuricemia induced renal interstitial fibrosis is established for the first time, and the model is significant for researching related diseases.
Description
technical field [0001] The invention relates to a method for constructing an animal model of renal interstitial fibrosis caused by hyperuricemia. Background technique [0002] In recent years, with the improvement of living standards and the adjustment of diet structure, the incidence of hyperuricemia has been increasing year by year. According to reports on the prevalence of hyperuricemia in various places in recent years, there are currently about 120 million hyperuricemia patients in my country. It accounts for about 10% of the total population, and the prevalence of men over 40 is as high as 30-40%. The high incidence ages are middle-aged and elderly men and postmenopausal women, but there is a trend of younger people in recent years. [0003] Although hyperuricemia itself is asymptomatic, the kidney disease caused by it is seriously harmful. About 10-20% of patients with hyperuricemia will suffer from kidney disease, including interstitial nephritis, kidney stones, renal...
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Login to view more IPC IPC(8): A61K36/064A61K31/52
Inventor 李长贵崔凌凌
Owner 李长贵
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