Cod liver oil soft capsule and preparation method thereof

A technology for cod liver oil and soft capsules is applied in the field of medical and health food, and can solve the problems of softening and deterioration, the content and proportion of active ingredients that are easily oxidized and deteriorated, and the validity period of soft capsules is short, and achieves the effect of preventing oxidative deterioration.

Active Publication Date: 2014-12-24
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cod liver oil soft capsules currently on the market have the disadvantages of easy oxidation and deterioration of active ingredients and unstable content and ratio; short validity period of soft capsules, easy hardening or softening of the capsule shell, etc.

Method used

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  • Cod liver oil soft capsule and preparation method thereof
  • Cod liver oil soft capsule and preparation method thereof
  • Cod liver oil soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Glue making:

[0020] Put 123kg of glycerin and 300kg of purified water into the plastic tank, heat to 60-75°C, then put in 330kg of gelatin, stir evenly, and keep stirring for 40-50 minutes to obtain the glue mixture; vacuumize the glue mixture to control the vacuum degree -0.06Mpa or above, turn off the vacuum, open the exhaust valve, and check the viscosity of the glue solution at 20,000-35,000 mPa·s; pass the glue solution through a 80-100 mesh filter bag; keep the glue solution at 50-65°C for later use;

[0021] (2) Contents:

[0022] Weigh 450kg of cod liver oil and 0.55kg of natural vitamin E, and set aside; put the cod liver oil and natural vitamin E into the batching tank, stir for 15-30 minutes to obtain the total mixed oil, pass through a 80-120 mesh filter bag to obtain the content, and set aside ;

[0023] (3) Pressing pellets, shaping and drying:

[0024] Pressing pills: Press the soft capsule contents and glue into soft capsules in a rolling mode s...

Embodiment 2

[0025] Embodiment two: change raw material composition into gelatin 300kg, glycerin 136.3kg, purified water 270kg, cod liver oil 499.5kg, natural vitamin E 0.5kg, according to the method described in embodiment one, make cod liver oil soft capsule B.

Embodiment 3

[0026] Embodiment three: change raw material composition into gelatin 270kg, glycerol 150kg, purified water 240kg, cod liver oil 540kg, natural vitamin E 0.4kg, according to the method described in embodiment one, make cod liver oil soft capsule C.

[0027] Enhance immune function experiment report

[0028] 1 Materials and methods

[0029] 1.1 Sample: The cod liver oil soft capsule B obtained in Example 2, the recommended oral dose for humans is 1 g per day, and the adult body weight is calculated as 60 kg, and the equivalent dose is 0.0167 g / kg·bw.

[0030] 1.2 Experimental animals and grouping: 200 SPF-grade Kunming female mice, weighing 18g-22g, provided by Dongchuang Experimental Animal Science and Technology Service Department, Kaifu District, Changsha City (the experimental animal production license number is SCXK (Xiang) 2009-0012) . Feed was provided by the same unit. Each 40 mice is a large group, a total of five groups. In the immune group I, the carbon clearance...

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Abstract

The invention discloses a cod liver oil soft capsule and a preparation method thereof. The soft capsule is characterized in that every 1000 soft capsules comprise 450-540g of cod liver oil and 0.45-0.55g of natural vitamin E. As cod liver oil contains omega-3 fatty acid which is easy to oxidize and deteriorate, the soft capsule uses fat-soluble natural vitamin E as an antioxidant. In order to ensure that microbiological indicator meets the demand, weighing, capsule dissolving, proportioning, pelleting, sizing and drying are completed in a 100 thousand level clean area. Long-term stability tests show that the product is stable in period of validity within two years, the content of effective components, microbiological indicator and character and the like meet the regulation, and the shells of the soft capsules are not hardened and deteriorated. The safety experiment shows that the soft capsule has no remarkable toxic and side effects on mice for 30 days; the immunity enhancing function experiment shows that the soft capsule has the function of enhancing the immunity.

Description

technical field [0001] The invention relates to a cod liver oil soft capsule and a preparation method thereof, belonging to the technical field of medicine and health food. Background technique [0002] Cod (scientific name: Gadus), is one of the main edible fish. Cod is native to the cold waters of the North Atlantic from northern Europe to Canada and the eastern United States. At present, the main producing countries of cod are Canada, Iceland, Norway and Russia, and the main producing countries of Japan are Hokkaido. Cod is one of the fish with the largest annual catch in the world and has important economic value. Most of the cod live in the cold sea in the Pacific Ocean and the northern Atlantic Ocean with a water temperature of 0°C to 16°C. As long as it can move, it can eat anything and eat a lot, so it grows fast, and it can grow to a size of 1 meter in about 10 years; it also has strong reproductive ability, and a female fish with a body length of about 1 meter c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L1/29A23L33/00
Inventor 殷光玲曹霞
Owner BY HEALTH CO LTD
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