Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of compound in preparation of medicines for preventing and treating liver injury

A liver injury and compound technology, which is applied in the application field of compounds in the preparation of drugs for the prevention and treatment of liver injury, can solve problems such as liver damage, aggravation, and elevation, and achieve the effect of highlighting substantial characteristics and strong therapeutic activity

Inactive Publication Date: 2015-07-01
HUAIAN UNIV SCI PARK MANAGEMENT CO LTD
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intravenous nutrition, etc., can all cause liver damage to varying degrees. The early manifestations of these liver damage are often Elevation of ALT (transaminase) or bilirubin, if the cause is not eliminated, the liver damage will be further aggravated

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of compound in preparation of medicines for preventing and treating liver injury
  • Application of compound in preparation of medicines for preventing and treating liver injury
  • Application of compound in preparation of medicines for preventing and treating liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of the compound Aphanamgrandiol A tablet involved in the present invention:

[0012] Take 5 grams of compound Aphanamgrandiol A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0013] Embodiment 2: the preparation of compound Aphanamgrandiol A capsules involved in the present invention:

[0014] Get 5 grams of compound Aphanamgrandiol A, add 195 grams of starch, mix well, pack into capsules and make 1000 capsules.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0016] Experimental example 1. The effect of Aphanamgrandiol A on preventing and treating liver injury

[0017] (1) Protective effect of Aphanamgrandiol A on D-galactosamine (D-GalN)-induced acute liver injury in mice

[0018] The mice were divided into 5 groups. The control group was given intragastric administration of normal saline (0.3 mL·d-1) for 7 consecutive days, and intraperitoneal injection of normal saline (0.15 mL·10 g-1) on the seventh day; , 6.0mg·kg-1) Each group was given intragastric administration of normal saline and different concentrations of Aphanamgrandiol A (0.3mL·d-1) for 7 consecutive days, and intraperitoneally injected D-GalN (800mg·kg-1, 0.15 mL·10g-1), blood was collected after 16 hours, and AST and ALT activities were measured.

[0019] Table 1 Protective effect of Aphanamgrandiol A on acute liver injury induced by D-GalN

[0020]

[0021] Note: * p<0.01vs control group, #p<0.01vs D-GalN group

[0022] It can be seen from Table 1 that Apha...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention conducts a pharmacological study to Aphanamgrandiol A and discovers that the Aphanamgrandiol A has the protective effect on D-galactosamine (D-Ga1N)-induced acute liver injury of mice and CC14-induced acute liver injury of mice. Therefore, the Aphanamgrandiol A can be used to prepare medicines for preventing and treating liver injury or liver injury. An application of the Aphanamgrandiol A in preparation of medicines for preventing and treating liver injury provided by the invention is disclosed for the first time. As the framework type of the Aphanamgrandiol A is a novel framework type, and the activity of the Aphanamgrandiol A to therapeutical effect of liver injury is unexpectedly strong, the probability of giving any indication by other compounds does not exist. The Aphanamgrandiol A has remarkable substantive characteristics and meanwhile has a remarkable progress for treating liver injury.

Description

technical field [0001] The present invention relates to a new application of compound Aphanamgrandiol A, in particular to the application of Aphanamgrandiol A in the preparation of drugs for preventing and treating liver damage. Background technique [0002] There are multiple reasons for causing liver damage: 1. Viral infection: caused by a variety of hepatitis viruses, with strong infectivity, complex transmission routes, wide epidemic range, and high incidence rate. 2. Drugs or chemical poisons: Many drugs and chemical poisons can cause liver damage, drug-induced hepatitis or toxic hepatitis. 3. Alcoholism: Alcohol damages the liver very seriously. The consequences of the damage include alcoholic hepatitis, alcoholic fatty liver, and alcoholic cirrhosis, mainly due to the toxicity of alcohol (ethanol) and its metabolite acetaldehyde on liver cells. caused by direct damage. 4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insuffici...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/366A61P1/16
Inventor 张康
Owner HUAIAN UNIV SCI PARK MANAGEMENT CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com