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Mantis egg-case formula granules, and preparation method and quality control method thereof

A technology of formula granules and mulberry octopus is applied in the quality control of TLC identification. The novel mulberry octopus formula granules can solve the problems of uneven quality of mulberry octopus formula granules and achieve large-scale Large-scale production, scientific production, and convenient administration

Active Publication Date: 2015-03-25
安徽宏方药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no unified standard, and all manufacturers use enterprise standards for production and quality control, resulting in uneven quality of mulberry octopus formula granules

Method used

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  • Mantis egg-case formula granules, and preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Preparation of mulberry octopus formula granules:

[0023] (1) Weigh raw materials: mulberry octopus 10000g;

[0024] (2) Put the decoction pieces of mulberry octopus into the extraction tank, add water 18 times the amount of the decoction pieces, heat and decoct for 2.5 hours, filter the liquid medicine, filter the liquid medicine, pump the filtrate into the concentration tank, concentrate (the steam pressure is 0.04-0.2 Mpa, vacuum degree -0.04~-0.08MPa), concentrate to the extract with a relative density of 1.03~1.05 (80°C), pass through a 180-mesh sieve while it is hot, and set aside;

[0025] (3) Take the extract obtained in step (2), add 0.1Kg of maltodextrin, mix well, heat to 70°C, and spray dry (control the inlet air temperature at 175°C to 185°C, and the outlet air temperature at 85°C to 95°C.) , collect dry cream powder, set aside.

[0026] (4) Grind the dry cream powder obtained in step (3) and pass it through an 80-mesh sieve; dry granulate (adjust the ma...

Embodiment 2

[0028] Quality control method for TLC identification of mulberry octopus formula granules:

[0029] (1) Take 0.5g of mulberry octopus powder, add 20ml of ethanol, extract under reflux for 30 minutes, filter, evaporate the filtrate to dryness, add 2ml of ethanol to the residue to dissolve, and use it as the test solution for later use;

[0030] (2) Take 5g of the reference medicinal material of mulberry octopus, add 120ml of water, boil for 40 minutes, filter, evaporate the filtrate to dryness, add 20ml of ethanol to the residue, and make a solution of the reference medicinal material in the same way as (1), and set aside;

[0031] (3) Referring to the "Chinese Pharmacopoeia" 2010 edition, Appendix VIB thin-layer chromatography test, draw 7 μl of the two solutions of the test solution and the reference medicinal solution, respectively, and place them on the same silica gel G thin-layer plate. Butanol-glacial acetic acid-water of positive 3:1:1 is used as developing ...

Embodiment 3

[0034] Determination of moisture, particle size, solubility, loading difference and extracts in mulberry octopus formula granules:

[0035] The moisture, particle size, solubility and extracts in the 6 batches of mulberry octopus formula granules prepared by the above method were detected. Water content, solubility, and loading differences are tested by conventional methods. The extracts were determined according to the hot soak method (Appendix XA of the 2010 edition of the Chinese Pharmacopoeia) under the alcohol-soluble extracts determination method, using 70% ethanol as the solvent. The inspection results are shown in the table, indicating that all indicators meet the standards.

[0036] Table of test results

[0037] batch number moisture Solubility Loading difference granularity Leachate 1 3.5 qualified qualified qualified 44.8 2 3.8 qualified qualified qualified 44.8 3 3.5 qualified qualified qualified 45...

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Abstract

The invention discloses mantis egg-case formula granules, and a preparation method and quality control method thereof. The preparation method comprises the following steps: extracting the raw material mantis egg-case herbal pieces with water twice, concentrating under reduced pressure, carrying out spray drying, granulating by a dry process, and the like to obtain the mantis egg-case formula granules. Every gram of mantis egg-case formula granules is equivalent to 12-15 grams of crude drug. The mantis egg-case formula granules are subjected to quality identification by thin-layer chromatography. On the basis of the traditional Chinese medicine decoction, the invention combines the modern high-tech extractor, pharmaceutical technology and thin-layer chromatographic scanning technology, refers to the research of mantis egg-case chemical composition to perform extraction process research and thin-layer chromatography identification method research on the mantis egg-case, thereby obtaining the mantis egg-case formula granules which can be taken by being directly dissolved before use. The medicine can implement complete component extraction, scientific production and controllable quality, and can implement large-scale production. The medicine is convenient and sanitary to take, and convenient for storage.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine products, and more specifically relates to a novel mulberry octopus formula granule, a preparation method thereof and a quality control method for thin-layer chromatographic identification. Background technique [0002] Mulberry octopus: The nature and taste are "sweet, salty, and flat." (the current version of the Pharmacopoeia of the People's Republic of China). Efficacy and Indications "Consolidating essence and reducing urination, tonifying kidney and supporting yang. It is used for spermatorrhea and spermatorrhea, enuresis, frequent urination, and cloudy urine." (The current version of the Pharmacopoeia of the People's Republic of China). [0003] Mulberry octopuses are mostly used as medicine in decoction pieces, which are decocted before use. The quality of the decoction pieces is unstable and uncontrollable, and the quality of decoction is difficult to guarantee. It is i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61K9/16A61P15/00A61P13/00G01N30/90
Inventor 朱月信陈培胜廖彩震成守玲
Owner 安徽宏方药业有限公司
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