Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure and restoring glucose tolerance

A fertility, composition technology, applied in the field of improving fertility and/or inhibiting pregnancy obstruction and restoring glucose tolerance and composition, can solve the problem that no further data clinical research is published and the like

Inactive Publication Date: 2014-03-19
QUEENS UNIV OF KINGSTON
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the published initial responses of five patients were "motivating" (Carroll et al., Transplant Proc. 1991 Dec;23(6):3351-3), these published results were not conclusive and no further information was obtained from Data from this clinical study or no further clinical studies are disclosed

Method used

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  • Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure and restoring glucose tolerance
  • Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure and restoring glucose tolerance
  • Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure and restoring glucose tolerance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Example 1: Animals

[0111] All animal methods were in accordance with protocols approved by the Queen's University Animal Care Committee. One hundred and seventy-five type I diabetic NOD / ShiLtJ, twenty type II diabetic NONcNZO10 / LtJ and twenty-five diet-induced obese C57BL / 6J and five Ten BALBc female mice were housed in the Central Animal Research Unit at Queen's University, Kingston, Ontario, according to standard husbandry practices. All mice were purchased into the Animal Adoption Research Unit at the age of 7 years. NOD / ShiLtJ female mice, also called NOD, were used as an autoimmune-regulated type 1 diabetes model and were fed with 20% fortified protein pellets (Co-op Feed Company, Saskatoon, Canada). The NONcNZO10 / LtJ is also called NZO, which is used as a type I diabetes model for obesity regulation, and C57BL6 is also called DIO, such as Ortlepp et al. (Eur J Clin Invest2000 30:195-202), Andrikopoulos et al. (2001. New Zealand obese mice: Polygenic models ...

Embodiment 2

[0112] Example 2: Blood glucose monitoring

[0113] Blood glucose levels in all mice were regularly monitored every other week by tail vein puncture starting from 8 weeks of age by using a hyperglycometer (Accu-Chek Aviva / Roche Diagnostics, Laval, Quebec, Canada). Animals that were not fasted or had blood glucose values ​​≥ 14.9 mmol / L following the glucose challenge (glucose tolerance) test were considered diabetic. All normoglycemic animals had blood glucose values ​​less than 10.0 mM / L.

Embodiment 3

[0114] Example 3: Vaginal smear sampling and identification of specific stages of the estrous cycle in nulliparous animals

[0115]Staining of vaginal smears was obtained using the Papanicola Ubbelohde staining kit (Sigma Aldrich, Oakville, Ontario, Canada) at 09:00-10:00 am to identify the stages of the estrous cycle, and as before. Circulation patterns for individual animals were established as described (Koss L.G (ed.): The Papanicolaou Stain. In Diagnostic Cytology and its Histopathological Bases (Papanicolaou Stain: In Diagnostic Cytology and Its Histopathological Bases) 4th ed. Koss, Leopold; Melamed and Myron R.Eds. J.B. Lippincott Williams & Wilkins (LWW), Philadelphia. 1992; Vol.2: 1211-1221). In diabetic mice, after 4 weeks, in proestrus, Blood and virgin uteri were collected from nulliparous diabetic NOD female mice during the estrous and anestrous phases. Blood and uteri were collected from age-matched naive NOD mice treated with tacrolimus immediately after com...

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Abstract

Methods and compositions for enhancing fertility and / or inhibiting pregnancy failure, restoring glucose tolerance and / or preventing glucose intolerance and / or maintaining glucose homeostasis and / or inducing or enhancing weight loss, treating dyslipidemia, treating hypertestosteronism or hyperandrogenism, and / or treating type 2 diabetes in an individual in need thereof are provided. These involve compositions that inhibit expression of interferon-gamma (IFN-gamma) or a downstreamIFN-gamma-stimulated gene, which is preferably a macrolide immunosuppressant compound.

Description

[0001] This application claims priority to US Provisional Patent Application Serial No. 61 / 558,586, filed November 11, 2011, and US Provisional Patent Application Serial No. 61 / 519,848, filed May 31, 2011. The entire contents of each of the above applications are hereby incorporated by reference herein. technical field [0002] The present invention relates to methods and compositions for improving fertility and / or inhibiting pregnancy arrest in individuals in need thereof. The invention also relates to methods for restoring glucose tolerance and / or preventing glucose intolerance and / or maintaining glucose homeostasis and / or increasing insulin sensitivity and / or treating type 2 diabetes and / or preventing weight gain in individuals in need thereof And / or methods and compositions for inducing or enhancing weight loss and / or treating dyslipidemia. The present invention also relates to methods and compositions for the treatment of hypertestosteronism or hyperandrogenism. Backgr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/436A61P15/08A61P3/00A61P3/04A61P3/10A61P5/28C07D491/18
CPCA61K31/436A61K31/439A61P15/08A61P3/00A61P3/04A61P5/28A61P3/10
Inventor A·J·H·阿巴格达迪F·W·K·凯
Owner QUEENS UNIV OF KINGSTON
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