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Medicinal preparation containing albizia flower total flavone

A technology of pharmaceutical preparations and total flavonoids, which is applied in the field of medicine and can solve problems such as difficulty in adherence to medication, strong side effects, and large dosages of patients

Active Publication Date: 2014-04-02
BEIJING SL PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional MAOIs and TCAs have significant antidepressant effects, but the dosage is large and the side effects are strong. The emergence of new antidepressants makes up for the shortage of such drugs, but in fact, because antidepressants need to be taken for a long time, their adverse reactions cannot be ignored Make it difficult for most patients to adhere to medication

Method used

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  • Medicinal preparation containing albizia flower total flavone
  • Medicinal preparation containing albizia flower total flavone
  • Medicinal preparation containing albizia flower total flavone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] [Example 1] Preparation of Albizia Julibrissin Total Flavonoids

[0076] Weigh 1 kg of dried Albizia Julibrissin, extract twice with 12 times the amount of 50% ethanol, successively for 1.5h and 1h, combine the extracts, filter, concentrate under reduced pressure at 60-70°C to 1 / 10 volume, add 1 times the amount of acetic acid Ethyl extraction was performed three times, and the ethyl acetate extracts were combined, concentrated under reduced pressure at 60-70°C, and dried under reduced pressure to obtain 39 g of total flavonoids from Albizia Julibrissin.

Embodiment 2

[0077] [Example 2] Prescription Composition and Preparation of Albizia Julibrissin Total Flavone Capsules

[0078]

[0079] Preparation method: Mix the total flavonoids extract of Albizia Julibrissin and glidant in the prescribed amount evenly, add the disintegrant to the above mixture; 20 mesh wet granulation, dry at 60°C, and sizing; add the disintegrant after drying Mixture; add the lubricant to the above mixture, mix evenly, pack into capsules, and obtain.

Embodiment 3

[0080] [Example 3] Prescription Composition and Preparation of Albizia Julibrissin Total Flavone Capsules

[0081]

[0082] Preparation method: Mix the total flavonoids extract of Albizia Julibrissin and glidant evenly in the prescribed amount, add the disintegrant to the above mixture; 20 mesh wet granulation, dry at 50°C, and granulate; add the disintegrant after drying Mixture; add the lubricant to the above mixture, mix evenly, pack into capsules, and obtain.

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Abstract

The invention provides a medicinal preparation containing albizia flower total flavone and medical application. The albizia flower total flavone contains the following components in percentage by weight: 41-50 percent of quercitrin, 0.1-10 percent of quercetin, 0.1-5 percent of kaempferide, 0.1-2 percent of quercetin-3-0-alpha-L-arabinoside, and quercetin-3-0-alpha-L-arabinoside. The invention also discloses a method for preparing the albizia flower total flavone medicinal preparation with high dissolution rate, as well as application of the albizia flower total flavone and medical preparation thereof serving as basic active substances in preparing a medicine for treating depression.

Description

Technical field: [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical preparation containing total flavonoids from Albizia Julibrissin. Background technique: [0002] Albizia julibrissin is the dried inflorescence or flower bud of Albizzia julibrissin Durazz., a leguminous plant. It is a commonly used traditional Chinese medicine. The main chemical components of Albizia Julibrissin include flavonoids, triterpenes and their glycosides, alkaloids, polysaccharides and organic acids. Modern pharmacological experiments have shown that the chemical components contained in Albizia Julibrissin have various pharmacological effects, such as sedation, hypnosis, anti-depression, immune function regulation, and anti-oxidation. Some published literatures have reported the pharmacological effects of Albizia julibrissin crude extract, which proves that it has a certain antidepressant effect. [0003] The inventor, through the extra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/48A61P25/24
Inventor 徐明波田园刘成东李学海李好好郝兴平白玉倩崔渊
Owner BEIJING SL PHARMA
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