A method for acquiring one-dimensional high-resolution nuclear magnetic resonance spectra under inhomogeneous magnetic field

Abstract

The invention provides a method of obtaining a high resolution nuclear magnetic resonance spectrum under a nonuniform magnetic field. The method comprises the steps of firstly applying a radio frequency pulse, rotating a magnetization vector from a Z axis to an XY plane, applying phase coding gradients along two directions, applying a sampling gradient of an echo plane spectrum imaging module on a third direction, collecting nuclear magnetic resonance signals, performing data permutation on the collected signals, and performing Fourier transform on a data matrix obtained by the permutation so as to obtain the nuclear magnetic resonance spectrums corresponding to a series of small voxels. The nuclear magnetic resonance spectrum corresponding to each small voxel is in high resolution; as the nonuniform magnetic field exists, the small voxels are directly projected in an accumulative mode, the obtain spectrums are in low resolution; the offset correction is performed on the spectrums corresponding to the small voxels, accumulative projection is then performed, the high resolution one-dimensional nuclear magnetic resonance spectrum can be obtained, and the obtained high resolution spectrum facilitates chemical analysis in a heterogeneous system.

Description

technical field [0001] The invention relates to a method for obtaining a high-resolution nuclear magnetic resonance spectrum, in particular to a method capable of obtaining a high-resolution nuclear magnetic resonance spectrum under an inhomogeneous magnetic field. Background technique [0002] High-resolution NMR spectra can provide information such as chemical shift, scalar coupling, spectral peak splitting mode, and relative spectral peak area ratio, thereby providing information on molecular structure and dynamics. It is widely used in physics, chemistry, biology, medicine and It has been widely used in materials science and other fields. For traditional high-resolution liquid NMR, the uniformity of the magnetic field generally exceeds 10 -8 . However, in many cases, the uniformity of the magnetic field will decrease, which cannot meet the requirements of sampling high-resolution NMR spectra. These cases include single-sided magnet NMR (Blümich B, Perlo J, Casanova F....

AI Technical Summary

Problems solved by technology

The above methods either cannot directly obtain high-resolution chemical shift information, or require prior information on the distribution of the inhomogeneous magnetic field, or have a low signal-to-noise ratio

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