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Application of pharmaceutical composition containing Yanhuning and pharmaceutically acceptable salt thereof in preparation of veterinary immune enhancer

The technology of an immune enhancer, Yanhuning, is applied in the field of preparation of veterinary immune enhancers, which can solve the problems of no data reports, etc., to improve immune antibodies and prevent animal diseases, enhance animal body immunity, and improve animal cells and body fluids. The effect of immune function

Active Publication Date: 2017-05-10
LUOYANG HUIZHONG ANIMAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] So far, there is no data report on the use of Yanhuning in veterinary clinics, and there is no application report on the use of Yanhuning to improve immunity

Method used

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  • Application of pharmaceutical composition containing Yanhuning and pharmaceutically acceptable salt thereof in preparation of veterinary immune enhancer
  • Application of pharmaceutical composition containing Yanhuning and pharmaceutically acceptable salt thereof in preparation of veterinary immune enhancer
  • Application of pharmaceutical composition containing Yanhuning and pharmaceutically acceptable salt thereof in preparation of veterinary immune enhancer

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1、5

[0058] Preparation of the Yanhuning premix of Preparation Example 1,5%

[0059] (1) Weigh 100 g of hydroxypropyl methylcellulose phthalate, 70 g of castor oil, add 2000 ml of 40% ethanol to dissolve, and mix well.

[0060] (2) Accurately weigh 106 g of potassium sodium 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinate half ester.

[0061] (3) Add the main ingredient and the coating solution (purely for clathrate) into the fluidized bed, and apply the spray method for coating.

[0062] (4) Dry to obtain 192g of Yanhuning premix, add starch to 2000g, and pack separately to obtain.

preparation Embodiment 2、10

[0063] The preparation of the Yanhuning powder of preparation example 2,10%

[0064] (1) Weigh 280g of polyacrylic acid resin, 220g of polyethylene glycol, add 5000ml of 60% ethanol to dissolve, and mix well.

[0065] (2) Accurately weigh 319 g of potassium sodium 14-dehydroxy-11,12-didehydroandrographolide-3,19-disuccinate half ester.

[0066] (3) Add the main ingredient and the coating solution into the fluidized bed, and apply the spray method for coating.

[0067] (4) Dry to obtain 573g of Yanhuning premix, add glucose to 3000g, and pack separately to obtain.

preparation Embodiment 3、1

[0068] Preparation of the Yanhuning Injection of Preparation Example 3, 1%

[0069] A. Weigh 2.7g of citric acid, 0.5g of L-cysteine ​​hydrochloride, 2.5g of sodium chloride, add 400ml of water for injection, and stir to dissolve.

[0070] B. Use 1 mol / L sodium hydroxide solution to adjust the solution to a pH value of 6-7, add 0.07% (w / v) medicinal charcoal, stir and adsorb for 20 minutes, and filter to decarbonize.

[0071] C, add 14-dehydroxyl-11,12-didehydroandrographolide-3,19-disuccinic acid half-ester potassium sodium 5.3g and stir to dissolve, adjust to corresponding pH value with 1mol / L sodium hydroxide solution to 6-7, add water for injection to 500ml, filter, pack in 5ml ampoules, 5ml each, and sterilize to obtain the injection containing Yanhuning.

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PUM

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Abstract

The invention provides an application of a medicinal composition containing dehydroandrographolide succinate and a pharmaceutically-acceptable salt thereof to preparation of a veterinary immunopotentiator. The dehydroandrographolide succinate is 14-desoxy-11,12-didehydroandrographolide-3,19-dihemisuccinate. The medicinal composition comprises 0.1-99 percent of dehydroandrographolide succinate and the salt thereof and the balance of carrier. By adopting the medicinal composition, the animal cell and humoral immune functions can be enhanced, the effect of regulating animal organism immunity is achieved, and especially, remarkable effects are achieved on the aspects of improvement on immune antibodies of animal vaccines and prevention of animal diseases.

Description

technical field [0001] The invention relates to the application of Yanhuning in enhancing body immunity, which can be used to prepare veterinary immune enhancer. Background technique [0002] Yanhuning is the potassium sodium salt of andrographolide half ester succinate, which is prepared from the active ingredient extracted from the traditional Chinese medicine Andrographis paniculata through esterification, dehydration, and salt formation. Its chemical name is 14-dehydroxyl-11,12-dide Hydroandrographolide-3,19-disuccinate half ester potassium / sodium salt. Yanhuning has heat-clearing, detoxifying and antiviral effects. It is mainly used clinically to treat viral pneumonia and upper respiratory tract infections caused by viruses. There are 188 approved drugs in the market, mainly including raw materials and injections. The clinical dosage forms are: There are two types of injection and injection powder, which can be used for intramuscular injection and intravenous injection...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K39/39A61K39/17A61K39/187A61P37/04A61P31/14A61P11/00A61P29/00
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
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