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A pharmaceutical composition for improving hypoxia tolerance and its preparation method and application

A technology of tolerance and composition, applied in the field of pharmaceutical compositions for improving hypoxia tolerance and the field of preparation thereof, can solve the problems of inconvenience to take, large toxic and side effects, etc., and achieves improved hypoxia tolerance and strict compatibility. , cheap effect

Inactive Publication Date: 2017-06-16
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many drugs and supplements that are clinically used to improve hypoxia tolerance, but these varieties have relatively toxic side effects and are inconvenient to take. So far, people are looking for a drug that is simple to make and easy to take to improve hypoxia tolerance

Method used

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  • A pharmaceutical composition for improving hypoxia tolerance and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: the preparation of granule

[0024] Take 50g of pudi ginseng, 20g of egg ginseng, 25g of Atractylodes macrocephala, 10g of Zeilan, 20g of Gansong, and 20g of licorice, mix them with medicinal materials, add water to decoct twice, add water to 8 times the weight of the medicinal materials for the first time, decoct for 1.5 hours, and decoct for the second time Add water for 6 times the weight of the medicinal materials, decoct for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.10 (65°C), add an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 65%, stir, and statically Put it in place for 24 hours, filter, reclaim ethanol from the filtrate and concentrate to the extractant with a relative density of 1.10 (65°C), and spray dry (conditions are that the inlet air temperature is 100°C, the outlet air temperature is 80°C, and the material temperature is 70°C, Atomization pressure is ...

Embodiment 2

[0025] Embodiment 2: the preparation of tablet

[0026] Take 40g of pudi ginseng, 30g of egg ginseng, 20g of Atractylodes macrocephala, 20g of euphemum, 15g of Gansong, and 25g of licorice, mix them with medicinal materials, add water to decoct twice, add water 10 times the weight of the medicinal materials for the first time, decoct for 2 hours, and add water for the second time The amount is 8 times the weight of the medicinal material, decocted for 1 hour, combined the decoction, filtered, the filtrate was concentrated to a relative density of 1.15 (65°C), added an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 75%, stirred, and stood for 24 hours, filtered, and the filtrate recovered ethanol and concentrated to the extract with a relative density of 1.25 (65°C), spray-dried (conditions were that the inlet air temperature was 120°C, the outlet air temperature was 90°C, the material temperature was 80°C, and atomized The pressure is 0.3 MPa...

Embodiment 3

[0027] Embodiment 3: the preparation of capsule

[0028] Take 30g of Pudi ginseng, 40g of egg ginseng, 15g of Atractylodes macrocephala, 30g of Zeilan, 10g of Gansong, and 30g of licorice, mix them with medicinal materials, add water to boil twice, add water to 10 times the weight of the medicinal materials for the first time, and cook for 1.5 hours, and then Add water for 8 times the weight of the medicinal materials, decoct for 1.5 hours, combine the decoctions, filter, concentrate the filtrate to a relative density of 1.15 (65°C), add an appropriate amount of ethanol to make the alcohol content (volume fraction) reach 75%, stir, Stand still for 24 hours, filter, the filtrate recovers ethanol and concentrates to the extractant with a relative density of 1.25 (65°C), spray-dried (conditions are that the inlet air temperature is 120°C, the outlet air temperature is 90°C, and the material temperature is 90°C , the atomization pressure is 0.4 MPa, and the spray speed is 7.5 / s.),...

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Abstract

The invention discloses a pharmaceutical composition for improving anoxia endurance. The pharmaceutical composition comprises 10 to 30 parts of calystegia hederacea, 20 to 40 parts of codonopsis convolvulacea, 15 to 25 parts of rhizoma atractylodis macrocephalae, 10 to 30 parts of herba lycopi, 10 to 30 parts of rhizoma nardostachyos, and 10 to 30 parts of liquorice; and the pharmaceutical composition can be prepared into a form of granules, tablet and capsule. The invention also discloses a preparation method of the pharmaceutical composition. The preparation method comprises the following steps: decocting with water; concentrating; precipitating with alcohol; performing spray drying; crushing the obtained particles into dry extract powder; and then adding auxiliary materials to prepare into the preparation as requirement. The invention also discloses application of the pharmaceutical composition in preparation of a medicine in improving anoxia endurance.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition for improving hypoxia tolerance and its preparation method and application. Background technique [0002] Every organ in the human body needs oxygen, and each organ has a different demand for oxygen. For example, the oxygen consumption of the brain is 25% of the total oxygen consumption of the human body, and the heart is 18%. These two organs consume the most oxygen. When the oxygen supply or utilization rate is reduced, the organs will be hypoxic, which will cause various chronic diseases (hypoxia is the source of all diseases), and of course acute hypoxia will cause suffocation and death. The improvement of hypoxia tolerance refers to the reduction of the organ's demand for oxygen, but at the same time, the organs can work normally. There are many drugs and supplements that are clinically used to improve hypoxia tolerance, but ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61P39/00
Inventor 张兴德吕翔郁红礼谢辉蔡宝昌
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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