Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device and its operation method

A technology for simulating moving bed and moving bed chromatography, which is applied in the field of five-zone series supercritical carbon dioxide fluid simulated moving bed chromatographic device, can solve problems such as the limitation of obtaining target objects in multi-component systems, and achieve separation cost saving and obvious economy and social benefits, the effect of avoiding the use of organic solvents

Active Publication Date: 2016-08-24
厦门昊琦科学仪器有限公司
View PDF11 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the current three-part and four-part supercritical fluid simulated moving bed designs can only separate two-component mixtures (one divided into two), and for complex multi-component systems, the target compound can only be obtained through secondary separation. The acquisition of target substances in multi-component systems has certain limitations

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device and its operation method
  • Five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device and its operation method
  • Five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device and its operation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] The five-zone series supercritical carbon dioxide fluid simulated moving bed chromatographic device of the present invention and its operating method, such as figure 1 , figure 2 , figure 2 (A), figure 2 (B), image 3 , image 3 (A), image 3 As shown in (B), it includes simulated moving bed chromatography, the simulated moving bed chromatography adopts supercritical carbon dioxide fluid as mobile phase; the simulated moving bed chromatography is composed of five zones connected in series, and each zone has at least one chromatographic column; The outlet port of the previous chromatographic column is connected to the inlet port of the next chromatographic column in turn through a switch valve, and the outlet port of the last chromatographic column is connected to the inlet port of the first chromatographic column; the inlet port of each chromatographic column They are respectively connected to the mobile phase inlet pipelines (17), (18), sample inlet pipelines (...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device and an operation method of the five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device. A supercritical fluid chromatography device and a liquid phase simulated moving bed chromatography device are integrated into the five-zone series supercritical fluid simulated moving bed chromatography device, especially the five-zone series supercritical fluid simulated moving bed chromatography device with supercritical carbon dioxide fluid as a flowing phase. Target component can be separated and extracted from multiple components in a continuous operation mode, a pressure gradient operation mode and a modifier gradient operation mode, the components are flexibly connected in series in a 4+3 mode or a 3+3 mode, one component in any position can be conveniently separated from the components, efficient, low-consumption, clean and large-scale chromatography separation of multiple component raw materials can be achieved, and the five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device is especially suitable for industrial preparation separation and can bring evident economic and social benefits.

Description

technical field [0001] The invention relates to a chromatographic device and its operating method, in particular to a five-zone series supercritical carbon dioxide fluid simulated moving bed chromatographic device and its operating method. Background technique [0002] With the development of preparative liquid chromatography technology and the research and development of a large number of active substances, as well as the demand for purification and separation of new drugs, high-efficiency, large-scale, green and energy-saving separation and purification technologies have attracted more and more attention. Laboratories use preparative liquid chromatography to separate and prepare pure substances on a small scale, which usually can only meet the needs of biological activity testing, toxicity research and clinical trial research. At present, although simulated moving bed chromatography (SMB) has appeared in the pharmaceutical preparation industry, the use of organic solvents,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/18B01D15/26
Inventor 许建中许晨
Owner 厦门昊琦科学仪器有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com