Five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device and its operation method

Abstract

The invention discloses a five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device and an operation method of the five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device. A supercritical fluid chromatography device and a liquid phase simulated moving bed chromatography device are integrated into the five-zone series supercritical fluid simulated moving bed chromatography device, especially the five-zone series supercritical fluid simulated moving bed chromatography device with supercritical carbon dioxide fluid as a flowing phase. Target component can be separated and extracted from multiple components in a continuous operation mode, a pressure gradient operation mode and a modifier gradient operation mode, the components are flexibly connected in series in a 4+3 mode or a 3+3 mode, one component in any position can be conveniently separated from the components, efficient, low-consumption, clean and large-scale chromatography separation of multiple component raw materials can be achieved, and the five-zone series supercritical carbon dioxide fluid simulated moving bed chromatography device is especially suitable for industrial preparation separation and can bring evident economic and social benefits.

Description

technical field [0001] The invention relates to a chromatographic device and its operating method, in particular to a five-zone series supercritical carbon dioxide fluid simulated moving bed chromatographic device and its operating method. Background technique [0002] With the development of preparative liquid chromatography technology and the research and development of a large number of active substances, as well as the demand for purification and separation of new drugs, high-efficiency, large-scale, green and energy-saving separation and purification technologies have attracted more and more attention. Laboratories use preparative liquid chromatography to separate and prepare pure substances on a small scale, which usually can only meet the needs of biological activity testing, toxicity research and clinical trial research. At present, although simulated moving bed chromatography (SMB) has appeared in the pharmaceutical preparation industry, the use of organic solvents,...

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Problems solved by technology

[0006] However, the current three-part and four-part supercritical fluid simulated moving bed designs can only separate two-component mixtures (one divided into two), and for complex multi-component systems, the target compound can only be obtained through secondary separation. The acquisition of target substances in multi-component systems has certain limitations

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