Apparatus for dissolving frozen polarized sample and applications

A sample and sample container technology, applied in the field of dynamic nuclear polarization, can solve problems affecting nuclear polarization, unreliable dissolution process, harmful solution pH value, etc.

Inactive Publication Date: 2014-10-01
GE HEALTHCARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In addition, prolonged dissolution will inadvertently affect nuclear polarization, as polarization in the dissolved sample weakens with time, and time variations will lead to an unreliable dissolution process, producing variable polarization
In addition, incomplete dissolution will affect process yield
Furthermore, in the case of free acids such as pyruvate, which must be neutralized upon polar dissolution, incomplete dissolution is detrimental for controlling the pH of the resulting solution

Method used

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  • Apparatus for dissolving frozen polarized sample and applications
  • Apparatus for dissolving frozen polarized sample and applications
  • Apparatus for dissolving frozen polarized sample and applications

Examples

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Embodiment Construction

[0030] figure 1 A prior art lysis stick 10 and sample container 12 are depicted. The dissolution rod 10 is used to dissolve polarized sample material 14 held in a sample container 12 .

[0031] As used herein, the term "sample" refers to a polarized material, which is typically held in a sample container, kept at cryogenic temperature in a frozen solid state. The term "dissolution medium" refers to a liquid provided for melting and dissolving a sample material thereby forming a "solution" of the melted and dissolved sample material and possibly at least some of the dissolution medium. The temperature of the dissolution medium is usually higher than that of the sample. The temperature of the sample is about 1 to 5K and the temperature of the dissolution medium is at least room temperature, ie about 295K, but preferably a heated, ie hot, dissolution medium is used. If an aqueous dissolution medium is used, such as an aqueous buffer, this aqueous buffer solution can be heated ...

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Abstract

DNP polarizer comprising a housing receiving a free end of a tubular fluid conduit positioned in fluid communication with a nozzle supported by said housing, said nozzle including an input port, a dispense port and a tapering inner surface or a stepped inner surface defining a nozzle flowpath extending in fluid communication between said input port and said dispense port.

Description

technical field [0001] The present invention relates to the field of dynamic nuclear polarization (DNP). More specifically, the present invention relates to a component for a dynamic nuclear polarization device. Even more specifically, the present invention relates to the features of dissolution equipment for DNP polarizers, ie the nozzles used as part of the dissolution apparatus. This nozzle provides more efficient dissolution of solid polarized samples, resulting in rapid and complete dissolution. Background technique [0002] From DNP in the solid state, i.e., polarization at very low temperature and moderate to high magnetic field, followed by dissolution with a dissolution medium, has been shown to generate highly enhanced nuclear polarization, enabling a novel MR application scope. For example, pyruvate is a compound that plays a role in the citric acid cycle, and DNP-polarized (hyperpolarized) pyruvate can be used as an MR agent for in vivo MR studies of metabolic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/48G01R33/30G01N1/38B01F1/00B01L99/00
CPCB01F1/0022G01N2001/1025G01R33/62G01N2001/383G01R33/307B01L3/0293G01R33/4808G01N1/38G01R33/282B01F21/20A61J1/2013B01L3/00G01N1/44
Inventor J.H.阿登克杰尔-拉森D.K.迪特里希K.A.格拉姆A.M.利奇P.米勒E.J.特尔费扬M.萨宁D.B.惠特
Owner GE HEALTHCARE LTD
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