38 results about "Dynamic nuclear polarisation" patented technology

The invention discloses a method for separating an oil-water two-phase NMR signal by utilizing dynamic nuclear polarization, which specifically comprises the following steps: adding a free radical forenhancing an aqueous phase or an oil phase NMR signal into a to-be-detected sample containing oil and water, and then carrying out dynamic nuclear polarization enhanced nuclear magnetic resonance analysis detection to obtain the aqueous phase or oil phase NMR signal. The method is simple and easy to operate, short in testing time and capable of efficiently separating oil-water two-phase NMR signals.

Provided are a low-field nuclear magnetic resonance device and a low-field nuclear magnetic resonance method. The low-field nuclear magnetic resonance device includes a dynamic nuclear polarization (DNP) amplification unit to amplify the nuclear polarization of hydrogen atoms of water using a DNP-possible substance (DNP substance) to provide the amplified nuclear polarization to a measurement target, a sensor unit to measure a magnetic resonance signal of the measurement target using a SQUID sensor or an optically-pumped atomic magnetometer, and a measurement field coil to apply a measurement field to the measurement target. The DNP amplification unit is separated from the measurement target, the sensor unit, and the measurement field coil.

A cooling system is provided. The cooling system is associated with a dynamic nuclear polarization system and configured to cool a sample to a temperature suitable for dynamic nuclear polarization to be carried out on the sample while the sample is in the cooling system. The cooling system includes a cryogenic chamber that includes a cryogenic fluid. The cooling system also includes a removable sample sleeve insertable within a portion of the cryogenic chamber. The removable sample sleeve is configured to define a sample path for the sample within the cryogenic chamber that is isolated from other parts of the cooling system.

Spin-labeled ice binding compounds (IBCs) including ice binding proteins (IBPs) or antifreeze proteins (AFPs) and their analogs may carry paramagnetic centers for dynamic nuclear polarization (DNP), for enhancing nuclear magnetic resonance (NMR) signal intensities. Use of spin-labeled IBCs to perform DNP exploits the IBCs' ability to homogeneously distribute the paramagnetic centers in frozen water solution at low temperature, leading to high DNP efficiency. Other advantages of using spin-labeled IBCs include cryo-protecting biological samples; cryo-preserving relative positions and orientations of the spin labeling groups; selecting positions and orientations of spin labeling groups with freedom and without technical barriers to making multiple spin labels in an IBC; and enabling use of a solvent that is primarily water for DNP at low temperatures in view of the potentially high water solubilities of spin-labeled IBCs.

DNP polarizer comprising a housing receiving a free end of a tubular fluid conduit positioned in fluid communication with a nozzle supported by said housing, said nozzle including an input port, a dispense port and a tapering inner surface or a stepped inner surface defining a nozzle flowpath extending in fluid communication between said input port and said dispense port.

Spin labeled ice binding compounds (IBCs) including ice binding proteins (IBPs), also called antifreeze proteins (AFPs) and their analogs are exploited to carry the paramagnetic centers for dynamic nuclear polarization (DNP), for enhancing nuclear magnetic resonance (NMR) signal intensities. Use of spin labeled IBCs to perform DNP exploits the IBCs' ability to homogeneously distribute the paramagnetic centers in frozen water solution at low temperature, leading to high DNP efficiency. Other advantages of using spin labeled IBCs include: (1) ability to cryo-protect biological samples; (2) the relative positions and orientations of the spin labeling groups in an IBC may also be cryo-preserved; (3) positions and orientations of spin labeling groups to an IBC can be selected with great freedom and without technical barrier to making multiple spin labels in an IBC; and (4) water solubilities of spin labeled IBCs are potentially high, enabling use of a solvent that is primarily water for DNP at low temperatures.

The present invention provides a variety of radicals, which are useful as polarizing compounds. Exemplary radicals are represented by compounds of Structural Formulae (I), (II), (III) and (IV) as described herein.

A non-local resistive NMR measurement method of the present invention belongs to the technical field of spintronics, and the main steps include: placing a two-dimensional electron gas Hall strip sample for non-local measurement on a sample rotating table In the cryostat, a quantum Hall ferromagnetic state with a magnetic domain structure is formed; non-local resistance measurement is performed on the quantum Hall ferromagnetic state, and the quantum Hall ferromagnetic state is obtained according to the relationship between the resistance peak and the inclination angle of the quantum Hall ferromagnetic state. According to the obtained NMR spectrum, the nuclear spin relaxation time T of the quantum Hall ferromagnetic state is measured. 1 and nuclear spin decoherence time T 2 Measurement. Through the introduction of the non-local measurement configuration, the present invention realizes the dynamic nuclear polarization under small current, thereby ensuring that the measured sub-state is always in an equilibrium state, and the non-local resistance of the measured sub-state is 2 orders of magnitude smaller than the normal measurement resistance , which improves the precision of resistive NMR measurement by an order of magnitude.