63results about "Analysis using double resonance" patented technology

Systems and methods for magnetic sensing and imaging include a sensor having a network of isolated electron-spin quantum bits (qubits) disposed on the surface of the sensor; and a solid state electronic spin system disposed below the surface of the sensor, wherein the solid state electronic spin system has a spin-state dependent fluorescence; a source of light; a source of first external perturbation, wherein the source of first external perturbation generates a magnetic field; a source of second external perturbation; wherein, the source of light and the first and second external perturbations are configured to coherently and independently manipulate the spin states of at least one qubit and at least one solid state electronic spin system; and a detector to optically measure the solid-state electronic spins spin-state dependent fluorescence.

The invention concerns a method for the hyperpolarisation of 13C nuclear spin in a diamond, comprising an optical pumping step, in which colour centre electron spins in the diamond are optically pumped. The method further comprises a transfer step in which the polarisation of a long-lived state of the colour centre electron spins is transferred to 13C nuclear spins in the diamond via a long-range interaction.

A method for performing sub-nanometer three-dimensional magnetic resonance imaging of a sample under ambient conditions using a diamond having at least one shallowly planted nitrogen-vacancy (NV) center. A driving radio-frequency (RF) signal and a microwave signal are applied to provide independent control of the NV spin and the target dark spins. A magnetic-field gradient is applied to the sample with a scanning magnetic tip to provide a narrow spatial volume in which the target dark electronic spins are on resonance with the driving RF field. The sample is controllably scanned by moving the magnetic tip to systematically bring non-resonant target dark spins into resonance with RF signal. The dark spins are measured and mapped by detecting magnetic resonance of said nitrogen-vacancy center at each of said different magnetic tip positions. The dark-spin point-spread-function for imaging the dark spins is directly measured by the NV center.

Systems and methods for magnetic sensing and imaging include a sensor having a network of isolated electron-spin quantum bits (qubits) disposed on the surface of the sensor; and a solid state electronic spin system disposed below the surface of the sensor, wherein the solid state electronic spin system has a spin-state dependent fluorescence; a source of light; a source of first external perturbation, wherein the source of first external perturbation generates a magnetic field; a source of second external perturbation; wherein, the source of light and the first and second external perturbations are configured to coherently and independently manipulate the spin states of at least one qubit and at least one solid state electronic spin system; and a detector to optically measure the solid-state electronic spins spin-state dependent fluorescence.

A double-resonance structure for DNP-NMR experiments and / or ENDOR experiments and methods using such a double-resonance structure. The double-resonance structure comprises a microwave resonator for generating electromagnetic fields suitable for EPR and an HF resonator for generating electromagnetic fields suitable for NMR. The HF resonator is formed by a strip resonator, a section of the strip resonator at the same time forming a portion of the microwave resonator.

Cycling sidebands arising from broadband decoupling of I-S heteronuclei are separated from the decoupled I spectra investigated in a 2D pulse sequence wherein I excitation 50 is followed after the interval δ+t1 with refocusing π pulse 54 operating on the I spins. After I excitation 50, the JIS coupling is inverted by π pulse 52 and immediately following the π pulse 54, decoupling 56 is turned on and maintained while signal acquisition in the interval t2 is initiated at δ+t1 after pulse 54. Double FT yields a 2D spectrum with sidebands completely displaced to diagonal locii, or alternatively the time domain data may be accumulated into respective t2 locations by effectively summing over t1 to yield a single dimensional spectrum free of cycling sidebands.

A method for optically storing and retrieving information is provided that irradiates spin-defect centers in a substrate with red or blue light to change the charge state to form a pattern. This pattern encodes information and long-term data storage. The information is retrieved by irradiating the pattern with red light that causes the pattern to undergo fluorescence.

The invention discloses a parallel magnetic resonance method based on dynamical nuclear polarization multinuclear simultaneous enhancement. An electronic-nuclear spin system is located in a magnetic field with the strength of B0; the electronic-nuclear spin system is irradiated through microwaves; microwave irradiation is stopped; nuclear magnetic resonance pulses are applied; enhancement signals of atomic nucleuses corresponding to all channels are collected; enhancement spectrograms or images are reestablished and obtained. Under the condition of saturated electrons, signal enhancement of multiple atomic nucleuses can be obtained at the same time. The mutual relation between different atomic nucleuses and electrons and the mutual relation between the atomic nucleuses can be obtained at the same time. Under the condition of a single saturated electron, enhancement images of different atomic nucleuses can be obtained at the same time, and the two-dimensional and multi-dimensional spectrograms of different atomic nucleuses can be obtained.

The invention provides a magnetic resonance apparatus for rapid and reliable detection and recognition of a trace of specific substances, and relates to detection and recognition of taggant substances having predefined zero external field magnetic resonance signatures. An object comprising taggant substance(s) is irradiated with a sequence of specific excitation pulses of electromagnetic radiation within a predetermined time and frequency scanning pattern, responsive nuclear spin echo signals are received from the object with a predetermined time and frequency acquisition pattern and data indicative thereof is generated. The scanning and acquisition patterns used permit successive transmission of pulses of multiple frequencies using a two-pulse spin-echo excitation technique, or a steady state-spin echo excitation technique, and successive acquisition of multiple nuclear spin echo response signals, within a time slot between two successive excitation pulses of a specific excitation frequency. The generated data is correlated with reference data corresponding to predetermined taggant substance(s) and one or more taggant substances are identified based on the determined correlation.

Here we present a solid-state spin sensor with enhanced sensitivity. The enhanced sensitivity is achieved by increasing the T2* dephasing time of the color center defects within the solid-state spin sensor. The T2* dephasing time extension is achieved by mitigating dipolar coupling between paramagnetic defects within the solid-state spin sensor. The mitigation of the dipolar coupling is achieved by applying a magic-angle-spinning magnetic field to the color center defects. This field is generated by driving a magnetic field generator (e.g., Helmholtz coils) with phase-shifted sinusoidal waveforms from current source impedance-matched to the magnetic field generator. The waveforms may oscillate (and the field may rotate) at a frequency based on the precession period of the color center defects to reduce color center defect dephasing and further enhance measurement sensitivity.

The invention discloses a method for measuring oil-water distribution by using DP-MRI. The method comprises the following steps: 1, adding free radicals for DNP enhanced water phase or oil phase NMR signals into a to-be-measured sample containing oil and water; 2, performing an MRI experiment on the to-be-detected sample, and acquiring an MRI image without DNP enhancement of the to-be-detected sample; 3, applying microwave excitation under the same MRI experiment condition as the step 2, and carrying out DNP-MRI testing: collecting an MRI image of the to-be-tested sample after DNP enhancement;and 4, comparing the MRI image after DNP enhancement with the MRI image without DNP enhancement, wherein in the MRI image after DNP enhancement, the area with enhanced MRI signal intensity is a selective enhanced fluid phase distribution area, and the area with unobviously changed MRI signal intensity is a non-selective enhanced fluid phase distribution area. The method is simple, convenient to operate, short in measurement time and high in measurement efficiency.

The invention discloses a method for separating an oil-water two-phase NMR signal by utilizing dynamic nuclear polarization, which specifically comprises the following steps: adding a free radical forenhancing an aqueous phase or an oil phase NMR signal into a to-be-detected sample containing oil and water, and then carrying out dynamic nuclear polarization enhanced nuclear magnetic resonance analysis detection to obtain the aqueous phase or oil phase NMR signal. The method is simple and easy to operate, short in testing time and capable of efficiently separating oil-water two-phase NMR signals.

A double-resonance structure for DNP-NMR experiments and / or ENDOR experiments and methods using such a double-resonance structure. The double-resonance structure comprises a microwave resonator for generating electromagnetic fields suitable for EPR and an HF resonator for generating electromagnetic fields suitable for NMR. The HF resonator is formed by a strip resonator, a section of the strip resonator at the same time forming a portion of the microwave resonator.

A method and apparatus for polarizing nuclear or electronic spins is disclosed. An analyte is passed near a surface that has a plurality of spin defect centers implanted within 10 nm of the surface. The spin defect centers are exposed to a magnetic field and illumination to produce polarized spins. The polarized spins then induce spin polarization in the analyte.

Here we present a solid-state spin sensor with enhanced sensitivity. The enhanced sensitivity is achieved by increasing the T2* dephasing time of the color center defects within the solid-state spin sensor. The T2* dephasing time extension is achieved by mitigating dipolar coupling between paramagnetic defects within the solid-state spin sensor. The mitigation of the dipolar coupling is achieved by applying a magic-angle-spinning magnetic field to the color center defects. This field is generated by driving a magnetic field generator (e.g., Helmholtz coils) with phase-shifted sinusoidal waveforms from current source impedance-matched to the magnetic field generator. The waveforms may oscillate (and the field may rotate) at a frequency based on the precession period of the color center defects to reduce color center defect dephasing and further enhance measurement sensitivity.

A composition containing (1) a porous material and (2) a polarization source for dynamic nuclear polarization containing a molecule capable of being in an excited triplet state. According to the composition, a dynamic nuclear polarization system that has a long spin-lattice relaxation time and can readily introduce the polarization object thereto can be provided.

The nuclear spin hyperpolarization method includes the steps of: irradiating a sample, prepared by doping solid benzoic acid derivative with a pentacene derivative, placed in a space where a static magnetic field is formed by a main magnetic field forming unit, with a laser beam from a laser source; following the light irradiation, irradiating the sample with a microwave from a microwave source while applying a sweeping magnetic field; and after repeating the application of sweeping magnetic field, light irradiation and microwave irradiation, dissolving the benzoic acid derivative in the sample. This enables generation of an aqueous solution containing benzoic acid derivative of which nuclear spins are hyperpolarized.

The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.

An apparatus for generating and measuring bending vibration in a pipe buried underground or a pipe covered by insulating materials is disclosed. There is provided an apparatus for generating and measuring bending vibration in a non-ferromagnetic pipe without physical contact, comprising: a ferromagnetic strip adhered on a surface of the pipe; a coil wound around the surface of the pipe; two magnets for generating bias magnetic field, applied to the strip and parallel to the strip; a power source for supplying an electric current to the coil; and a measuring unit for measuring variation of voltage across the coil, the variation of the voltage being generated due to a strain according to inverse magnetostrictive effect, the strain being generated due to bending vibration, the bending vibration being generated due to deformation of the strip, the deformation being induced according to magnetostrictive effect as the power source supplies the electric current to the coil.

An NMR (nuclear magnetic resonance) probe head has a microwave resonator with at least two elements which are reflective in the microwave range, at least one of which is focusing. The reflective elements at least partly delimit a resonance volume of the microwave resonator. At least one of the reflective elements is a DBR (“Distributed Bragg Reflector”), and the NMR probe head has at least one NMR coil integrated into the DBR. The NMR detection coil can thereby be positioned particularly near to the sample and the distortions of the static field by resonator components are reduced, such that the detection sensitivity and the spectral resolution of the experiment are significantly improved.

The present application discloses a sensor system that includes a sensor having a sensor surface, a sample cartridge including one or more flexible membranes and a membrane frame, the membrane frame including one or more openings covered by the one or more flexible membranes defining one or more wells for holding one or more samples, the flexible membrane having a sample side supporting the sample and an opposite sensor side, the sample cartridge being removably insertable in the sensor system such that the sensor side of the flexible membrane is positioned above and faces the sensor surface, a displacement mechanism that can be actuated to displace the flexible membrane toward the sensor surface such that the sample is moved to a position closer to the sensor surface, and an optical imaging system that detects light emitted from the sensor. Disclosed also are a cartridge cassette and a method of use.

The present invention is directed to a new class of synthetic carbohydrate receptor compounds comprising Formula I as described herein: (I). Other aspects of the present invention relate to pharmaceutical compositions and pharmaceutical delivery vehicles comprising the compound of Formula (I) The present invention is also directed to methods of treatment and diagnosis that involve the administration of a compound of Formula (I).

A synchronized readout (SR) technique for spectrally selective detection of oscillating magnetic fields with sub-millihertz resolution, using coherent manipulation of solid state spins.

An object is to provide a method for enhancing a nuclear spin polarization. Triplet DNP where a pentacene derivative represented by the following formula (A) is used as a polarizing agent enables an effective enhancement in nuclear spin polarization to be achieved. In formula (A), each R independently represents a hydrogen atom (—H), a deuterium atom (-D), or a hydrocarbon group having 1 to 20 carbon atoms which optionally includes at least one atom selected from the group consisting of an oxygen atom, a sulfur atom and a silicon atom, provided that at least one R represents a hydrocarbon group having 1 to 20 carbon atoms which optionally includes at least one atom selected from the group consisting of an oxygen atom, a sulfur atom and a silicon atom.

A hyperpolarized liquid contrast agent is for use in a MRT device. The liquid contrast agent passes through a conduit of a MW resonator in the magnetic field of the MRT device. A microwave with a frequency of at least 40 GHz couples into the MW resonator for polarizing the liquid contrast agent upon passage through the conduit in the MW resonator using DNP. The contrast agent is polarized in a continuous passage in the MW resonator and administered immediately. A MW mode is formed in the MW resonator which has an antinode in the magnetic field strength and a node in the electric field strength. The power of the introduced microwave and coupling of the microwave into the resonator are adjusted such that in the area of the line, an amplitude of the MW magnetic field strength B1≧1.5·10−2 Ts 1 / T1,e results, wherein T1,e is the relaxation time of the DNP-active electrons.

An NMR based method for characterising the metabolic stability of a drug candidate comprising the steps of enhancing the nuclear polarisation of NMR active nuclei present in the drug candidate (hereinafter termed “hyperpolarisation”), contacting the drug candidate with liver cells or cell organelles, and carrying out NMR analysis.

An MRI pulse sequence is disclosed. The pulse sequence involves a plurality of slice selective pulses (51,55) which each individually have a desired rotation that is less than or equal to the total desired rotation. The slice selective pulses each cause a rotation about respective axes, which may be different to each other. Optionally phase correction (re-phasing) gradients (53, 56) can also be included in the pulse sequence.

A method for performing sub-nanometer three-dimensional magnetic resonance imaging of a sample under ambient conditions using a diamond having at least one shallowly planted nitrogen-vacancy (NV) center. A driving radio-frequency (RF) signal and a microwave signal are applied to provide independent control of the NV spin and the target dark spins. A magnetic-field gradient is applied to the sample with a scanning magnetic tip to provide a narrow spatial volume in which the target dark electronic spins are on resonance with the driving RF field. The sample is controllably scanned by moving the magnetic tip to systematically bring non-resonant target dark spins into resonance with RF signal. The dark spins are measured and mapped by detecting magnetic resonance of said nitrogen-vacancy center at each of said different magnetic tip positions. The dark-spin point-spread-function for imaging the dark spins is directly measured by the NV center.