24results about "Analysis using double resonance" patented technology

The present disclosure provides a method for production line nuclear magnetic resonance (NMR) measurement of a fluid containing one or more evaluated materials. The method includes positioning a reference sample with a known reference material and a sample of the fluid within a sensing region of an NMR measurement unit coil and a magnetic field of a permanent magnet. An NMR measurement is performed by feeding at least one radio frequency coil with a signal having a spectrum including characteristic frequencies of the evaluated materials and the reference material, generating detection signals. The detection signals are processed to provide an NMR spectrum with a reference peak and additional peaks. The signal is adjusted based on changes over time of the reference peak frequency, and a band pass frequency range of a receiving unit is adjusted based on the reference peak frequency.

In a general embodiment, a magnetic resonance system performs magnetic resonance measurements. In some examples, the magnetic resonance system includes a data processing unit and a superheterodyne spectrometer system. The data processing unit generates digital intermediate frequency (IF) signal information based on the pulse profile. The digital IF signal information is configured to suppress image sidebands in the magnetic resonance control signal. The superheterodyne spectrometer generates the magnetic resonance control signal based on the digital IF signal information.

Systems and methods for containing parahydrogen are disclosed. In some of the systems and methods, a gas cylinder is configured to contain hydrogen gas therein. The hydrogen gas may include parahydrogen gas at a first concentration of at least 45% and a pressure of up to 40 bar. The parahydrogen gas may have a decay time constant of at least 30 days. The parahydrogen gas may be for use in a PHIP, PHIP-SAH, SABRE, or PHIPNOESYS NMR or MRI experiment. In some of the systems and methods, a cryogenic chamber is configured to contain liquid hydrogen therein. The liquid hydrogen may include liquid parahydrogen at a concentration of at least 50 mole percent. The liquid hydrogen may be boiled to produce hydrogen gas containing at least 50 mole percent parahydrogen gas. The parahydrogen gas may be for use in a PHIP, PHIP-SAH, SABRE, or PHIPNOESYS NMR or MRI experiment.

To provide methods of fingerprinting a specific molecule in a composition using nuclear magnetic resonance (NMR).SOLUTION: The disclosed NMR methods provide several modifications and improvements over existing NMR techniques. In some embodiments, the methods include applying a cycle of signal processing steps, including: applying a radio frequency (RF) pulse; applying a gradient pulse having a pulse length less than or equal to 1000 μs; and applying a water suppression technique (WET). In some embodiments, the methods further include repeating the cycle for at least 3 times to acquire an enhanced signal of the composition. In some embodiments, the methods further include fingerprinting the specific molecule based on the enhanced signal of the composition.SELECTED DRAWING: None

A system and method for increasing the nuclear spin polarization of a target compound are disclosed. [Solution] According to this system and method, a first non-thermal equilibrium nuclear spin polarization may be conferred to a source atom of at least one source compound, the source atom having a nuclear gyromagnetic ratio of at least 12 megahertz (MHz / T) per tesla. A first solution containing the source compound and the target compound can be obtained. At least one source atom can be present in the first solution at a source concentration of at least 0.1 moles (M). At least 0.01% of a second non-thermal equilibrium nuclear spin polarization can be conferred to at least one target atom of the target compound via nuclear Overhauser effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to at least one target atom.

Systems and methods are disclosed for generating highly polarized molecules with high molar polarization. The systems and methods generally reduce or suppress strong demagnetizing fields that may otherwise result from polarizing high concentrations of molecules. Because such demagnetizing fields can hinder polarization transfer, reducing such fields increases molar polarization. The systems and methods generally use novel pulse sequences that counteract the effects of the demagnetizing fields.

The present invention relates to a catalyst for cumene hydroperoxide decomposition, wherein said catalyst has good efficacy, provides good decomposition of cumene hydroperoxide and good selectivity to main products, provides high yield percentage of alpha methyl styrene, and reduces the formation of unwanted byproducts. Said catalyst comprises zeolite beta, wherein said catalyst has the following characteristics: a) the mole ratio of silica to alumina is from 30 to 100; and b) the peak area ratio obtained from the analysis using 27Al magic angle spinning-nuclear magnetic resonance (27Al MAS-NMR) technique according to the following relation: (A+C+D) / B is from 0.1 to 0.3; wherein A, B, C, and D are the peak area at the peak position from 44 but less than 54 ppm, the peak area at the peak position from 54 to 58 ppm, the peak area at the peak position greater than 58 to 64 ppm, and the peak area at the peak position from -10 to 5 ppm, respectively, by the peak deconvolution analysis with Lorentz / Gauss function under the condition that the minimum distance between peaks for independent integration (AZFW) is equal to 0.5 ppm. Moreover, this invention relates to a preparation process of the catalyst comprising the step of contacting zeolite beta with polycarboxylic acid solution and calcination at the temperature in the range from 400 to 700 °C, wherein said polycarboxylic acid has the pKa of the first dissociation from 1.5 to 3.5 and has the molecular structure with at least one side having size larger than 6 Å. This invention also relates to a process for cumene hydroperoxide decomposition using said catalyst or catalyst prepared from said preparation process of the catalyst.

Systems and method for nuclear magnetic resonance (NMR) well logging use an inversion pulse sequence with a Carr-Purcell-Meiboom-Gill (CPMG) pulse sequence to improve spin magnetization calculations. Improved Bloch equation-based calculations consider conditions where a longitudinal relaxation time and a transverse relaxation time of the hydrogen nuclei (e.g., of a subterranean hydrocarbon pool and / or water) are within an order of magnitude of pulse durations for the inversion pulse sequence and the CPMG pulse sequence. Accordingly, an NMR response to the inversion pulse sequence and the CPMG pulse can be detected and used to calculate one or more spin magnetization values with higher accuracy amplitudes. Reservoir characteristics are determined based on the one or more spin magnetization values. As such, improved well operations (e.g., selecting a drilling site, determining a drilling depth, and the like) can be performed.

One of our goals is to provide labeled tyrosine molecules that can be excited to a hyperpolarized state, and methods that utilize these molecules. [Solution] A method comprising: a first step of exciting a labeled tyrosine molecule represented by formula (1) in a basic solution by dynamic nuclear polarization to obtain hyperpolarized labeled tyrosine; and a second step of performing NMR observation on a sample containing the hyperpolarized labeled tyrosine. In formula (1), R1 is independently a hydrogen atom or a deuterium atom, R2 is independently a hydrogen atom or a deuterium atom, and R3 is independently a hydrogen atom or a deuterium atom. [C1] TIFF2026075341000007.tif42170

A system and method for increasing the nuclear spin polarization of a target compound are disclosed. According to such a system and method, a first non-thermal equilibrium nuclear spin polarization may be imparted to source atoms of at least one source compound, the source atoms having a nuclear gyromagnetic ratio of at least 12 megahertz per Tesla (MHz / T). A first solution including a source compound and a target compound can be obtained. The at least one source atom can be present in the first solution at a source concentration of at least 0.1 molar (M). A second non-thermal equilibrium nuclear spin polarization of at least 0.01% can be imparted to at least one target atom of the target compound via a Nuclear Overhauser Effect (NOE) transfer of the first non-thermal equilibrium nuclear spin polarization to at least one target atom.

To provide a highly polarized object containing a molecule, the target of high polarization by triplet DNP, to which a polarization source can be added and in which a sufficient longitudinal relaxation time can be achieved, and a manufacturing method thereof, a high polarization method and a high polarization device.SOLUTION: A highly polarized object 100 includes a first molecule 102, a second molecule 104, and a polarization source 108, where at least one of the first molecule and the second molecule is a target molecule whose nuclear spin is to be highly polarized by triplet DNP, a molecule that is not the target molecule out of the first molecule and the second molecule is a coformer molecule, the first molecule and the second molecule comprise a co-crystalline crystal structure including a binding part 106, the supramolecular synthon with a hexagonal structure, and the polarization source is arranged at a position to displace a part of the crystal structure.SELECTED DRAWING: Figure 1

Systems and methods for containing parahydrogen are disclosed. In some of the systems and methods, a gas cylinder is configured to contain hydrogen gas therein. The hydrogen gas may include parahydrogen gas at a first concentration of at least 45% and a pressure of up to 40 bar. The parahydrogen gas may have a decay time constant of at least 30 days. The parahydrogen gas may be for use in a PHIP, PHIP-SAH, SABRE, or PHIPNOESYS NMR or MRI experiment. In some of the systems and methods, a cryogenic chamber is configured to contain liquid hydrogen therein. The liquid hydrogen may include liquid parahydrogen at a concentration of at least 50 mole percent. The liquid hydrogen may be boiled to produce hydrogen gas containing at least 50 mole percent parahydrogen gas. The parahydrogen gas may be for use in a PHIP, PHIP-SAH, SABRE, or PHIPNOESYS NMR or MRI experiment.

Provided is a production method for obtaining a polarized cocrystal of a first compound and a second compound, said method comprising (1) polarizing the first compound, and (2) mixing the polarized first compound and the unpolarized second compound to obtain the polarized cocrystal.

A passive filter circuit for simultaneous dual nuclear magnetic resonance quadrature transmission and reception is configured to apply to an input a quadrature phase shift of a first polarity at the Larmor frequency of a first nucleus and a quadrature phase difference of a second polarity opposite the first polarity at the Larmor frequency of a second nucleus.

An NMR probe head (1) for performing high-resolution, liquid-state DNP-NMR comprises a corrugated waveguide (3) for mw transmission, arranged along a longitudinal axis Z of the probe head; a system of at least two of mw reflecting mirrors (4-7) for mw beam transmission, focusing and reshaping the beam to match for a sample geometry; at least one RF coil (11,12) for NMR detection mounted in a way to allow mw passage to the sample area, characterized by a cooling system comprising a flow dewar tube (8) for feeding cryogenic fluid mounted at the side of the probe head and parallel to the corrugated waveguide and a thermally isolated sample chamber (26) surrounded by a chamber dewar (9); a sample spinning arrangement being configured to achieve uniform irradiation over a sample volume, to increase the sample volume under mw irradiation, and to reduce sample heating; a sample assembly (13) comprising concentric circular tubes or rods (15, 16) forming constraints for a sample layer (14). This arrangement is capable of exciting in particular even large sample volumes up to ~ 40μL.

The present invention relates to an inversion chamber (2) comprising at least one magnetization means, called at least one internal magnetization means (11, 12), which is at least partially located inside a magnetic shielding part (5) and which at least partially surrounds an inversion part (33), said magnetization means being configured to generate an inversion magnetic field, the main component of the inversion magnetic field being along the direction Z, which is inverted as it travels inside the inversion part (33), and inside the inversion part (33), as the solution flows at a non-zero speed from the chamber inlet to the chamber outlet inside the inversion part (33), to transfer the hyperpolarization from a first nuclear spin species to a second nuclear spin species (with scalar coupling between said nuclear spins). The present invention also relates to a device comprising this chamber and to a method implemented by said device.

The invention relates to a method for rapidly identifying types of edible oil based on combination of low-field nuclear magnetism and high-field nuclear magnetism. The invention relates to a method for rapidly identifying types of edible oil based on combination of low-field nuclear magnetism and high-field nuclear magnetism. According to the method, the edible oil is identified by adopting a low-field nuclear magnetic resonance detection technology and a high-field nuclear magnetic resonance detection technology. According to the method for rapidly identifying the types of the edible oil based on the combination of the low-field nuclear magnetism and the high-field nuclear magnetism, the problems that in the prior art, the sample treatment requirement is too high, and only grease characteristics can be observed in a single mode are solved through the combination of the low-field nuclear magnetism and the high-field nuclear magnetism; and associating the data model with the chemical parameters to realize rapid and lossless identification of the types of the edible oil.

A highly polarized object 100 includes first molecules 102, second molecules 104, and a polarization source 108. At least one of the first molecules and the second molecules are target molecules, for which the atomic nucleus spin is to be highly polarized by a triplet DNP. Among the first molecules and the second molecules, the molecules that are not target molecules are coformer molecules. The first molecules and the second molecules constitute a crystal structure of a co-crystal including a coupling part 106 that is a supramolecular shynthon having a hexagonal structure. The polarization source is arranged at a position where part of the crystal structure is replaced.

An NMR probe (1) for performing high resolution, liquid DNP-NMR, comprising: a corrugated waveguide (3) for mw transmission arranged along a longitudinal axis Z of the probe (1); a system of at least two mw mirrors (4-7) for mw beam transmission, focusing and shaping of the beam to match the sample geometry; at least one RF coil (11, 12) for NMR detection, mounted to allow the passage of mw to the sample region, characterised in that the cooling system comprises a flow Dewar tube (8) mounted at the side of the probe and parallel to the corrugated waveguide for feeding a cryogenic fluid, and an insulated sample chamber (26) surrounded by a chamber Dewar (9); a sample rotation device configured to achieve uniform irradiation on the sample volume to increase the sample volume under mw irradiation and reduce sample heating; a sample assembly (13) comprising concentric circular tubes or rods (15, 16) forming a constraint on the sample layer (14). This arrangement can excite large sample volumes, in particular even up to-40 [mu] L.

The embodiment of the invention provides a multi-nuclide nuclear magnetic resonance instrument. The multi-nuclide nuclear magnetic resonance instrument comprises a radio frequency transceiver module, a switch control module, a duplexer module, an impedance matching network and a sample sending tube. The radio frequency transceiver module is connected with the switch control module, a first output end of the switch control module is connected with the duplexer module, and a second output end of the switch control module is connected with the impedance matching network. The impedance matching network comprises a resistance-capacitance circuit and a radio frequency coil, and the radio frequency coil is arranged on the outer side of the sample feeding pipe. And the switch control module switches the circuit structure of the impedance matching network based on the radio frequency pulse transmitted by the radio frequency transceiver module, so that the radio frequency coil outputs a radio frequency wave with a target frequency to excite nuclide of a sample in the sample sending tube. According to the multi-nuclide nuclear magnetic resonance instrument, the circuit structure of the impedance matching network is switched, so that the radio frequency coil can stably resonate under different frequencies, stable resonance and impedance matching are realized under a relatively large frequency span, and the signal acquisition efficiency and the signal-to-noise ratio are improved.

The present invention discloses a method for optimizing the sampling trajectory of a molecular exchange magnetic resonance (MEL) measurement. The method includes the steps of: (1) determining the number and corresponding range of physiological / physical parameters of a molecular exchange system and generating a simulated physiological / physical parameter dataset; (2) determining a molecular exchange magnetic resonance measurement method and setting the acquisition parameters; (3) constructing an end-to-end integrated network model including a sampling trajectory optimization network, a noise signal generation network, and a parameter estimation network; and (4) training the network using the simulated physiological / physical parameters as input, and obtaining the optimized sampling trajectory and the corresponding parameter estimation network once the network has converged and training is complete. The present invention further discloses a molecular exchange magnetic resonance measurement method and apparatus. The method for optimizing the sampling trajectory of a molecular exchange magnetic resonance measurement provided by the present invention improves the efficiency and accuracy of physiological / physical parameter estimation and can be applied to various molecular exchange magnetic resonance measurement methods.

A coherence model predicts the coherence time of one spin qubit based on decoherence caused by a surrounding spin bath. This coherence model, which is constructed by performing cluster correlation expansion calculations of spin-bath-induced decoherence, includes a library of coherence time distributions over a parameter-space range. Using this library, maximum likelihood estimation is then performed on a set of experimental data, enabling the density of the spin bath and the dimensionality of the spin qubits to be determined, given certain geometrical constraints. Rather than relying on assumptions that average over interactions between bath spins and central qubit spins, the present embodiments simulate the dynamics of the entire interacting spin bath, producing a quantum mechanical characterization technique for quantum applications that can be incorporated into a feedforward synthesis loop.