Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Parallel magnetic resonance method based on dynamical nuclear polarization multinuclear simultaneous enhancement

A technology of dynamic nuclear polarization and nuclear magnetic resonance, which is used in the analysis of double resonance, etc., can solve the problems of low sample temperature, difficult to meet the requirements of biological samples, and long sample relaxation time.

Active Publication Date: 2016-06-29
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
View PDF6 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, this method requires the sample temperature to be low, and on the other hand, the relaxation time of the sample after dissolution is relatively long, but most of the actual biological samples are difficult to meet the requirements.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Parallel magnetic resonance method based on dynamical nuclear polarization multinuclear simultaneous enhancement
  • Parallel magnetic resonance method based on dynamical nuclear polarization multinuclear simultaneous enhancement
  • Parallel magnetic resonance method based on dynamical nuclear polarization multinuclear simultaneous enhancement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The technical solution of the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0026] A parallel magnetic resonance method based on dynamic nuclear polarization multi-nuclear sensitivity enhancement, mainly comprising the following steps:

[0027] Step 1, the electron-nuclear spin system composed of electrons and nuclei whose nuclear spin is not 0, when the electron-nuclear spin system is at a strength of B 0 In a magnetic field, the electron-nuclear spin system will produce energy level splitting (such as figure 1 Shown is the distribution diagram of a typical four-energy level system split into an electron-nuclear spin system composed of an electron and a nucleus with a nuclear spin of 1 / 2, and the four energy levels are 1, 2, 3, 4, respectively). Due to relaxation between these energy levels, the number of particles will change, but eventually these energy levels will be in thermal equilibrium, that is, the...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a parallel magnetic resonance method based on dynamical nuclear polarization multinuclear simultaneous enhancement. An electronic-nuclear spin system is located in a magnetic field with the strength of B0; the electronic-nuclear spin system is irradiated through microwaves; microwave irradiation is stopped; nuclear magnetic resonance pulses are applied; enhancement signals of atomic nucleuses corresponding to all channels are collected; enhancement spectrograms or images are reestablished and obtained. Under the condition of saturated electrons, signal enhancement of multiple atomic nucleuses can be obtained at the same time. The mutual relation between different atomic nucleuses and electrons and the mutual relation between the atomic nucleuses can be obtained at the same time. Under the condition of a single saturated electron, enhancement images of different atomic nucleuses can be obtained at the same time, and the two-dimensional and multi-dimensional spectrograms of different atomic nucleuses can be obtained.

Description

technical field [0001] The invention relates to the field of magnetic resonance, in particular to a parallel magnetic resonance method based on dynamic nuclear polarization multi-nuclear simultaneous enhancement. This method is mainly used to improve the sensitivity of magnetic resonance signals, and is suitable for the research of magnetic resonance spectroscopy and imaging of materials such as biology, chemical molecules and proteins. Background technique [0002] Because it can greatly enhance the sensitivity of NMR signals, the dynamic nuclear polarization (DNP) technique based on electron-nuclear polarization transfer has become a very important and commonly used method. In terms of dielectric solid DNP research, researchers have found solid enhancement effects, thermal mixing effects, and crossover effects. However, solid DNP changes the population number of nuclei by exciting forbidden transitions, that is, the enhancement of solid DNP depends on the resonant frequen...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N24/12
CPCG01N24/12
Inventor 刘朝阳贺玉贵冯继文张震
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com